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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
G-protein coupled receptors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q37.1
Chromosome location (bp)
230907318 - 230961066
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways 1,2,3. Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation 4. In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
G-protein coupled receptor, Receptor, Transducer
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A8K858 [Target identity:100%; Query identity:100%] G protein-coupled receptor 55; G protein-coupled receptor 55, isoform CRA_a; cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA
GO:0004930[G protein-coupled receptor activity] GO:0004949[cannabinoid receptor activity] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0035025[positive regulation of Rho protein signal transduction] GO:0038171[cannabinoid signaling pathway] GO:0045453[bone resorption] GO:0045671[negative regulation of osteoclast differentiation] GO:0051482[positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway] GO:0070374[positive regulation of ERK1 and ERK2 cascade]
A8K858 [Target identity:100%; Query identity:100%] G protein-coupled receptor 55; G protein-coupled receptor 55, isoform CRA_a; cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA
GO:0004930[G protein-coupled receptor activity] GO:0004949[cannabinoid receptor activity] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0035025[positive regulation of Rho protein signal transduction] GO:0038171[cannabinoid signaling pathway] GO:0045453[bone resorption] GO:0045671[negative regulation of osteoclast differentiation] GO:0051482[positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway] GO:0070374[positive regulation of ERK1 and ERK2 cascade]
A8K858 [Target identity:100%; Query identity:100%] G protein-coupled receptor 55; G protein-coupled receptor 55, isoform CRA_a; cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA
GO:0004930[G protein-coupled receptor activity] GO:0004949[cannabinoid receptor activity] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0035025[positive regulation of Rho protein signal transduction] GO:0038171[cannabinoid signaling pathway] GO:0045453[bone resorption] GO:0045671[negative regulation of osteoclast differentiation] GO:0051482[positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway] GO:0070374[positive regulation of ERK1 and ERK2 cascade]
A8K858 [Target identity:100%; Query identity:100%] G protein-coupled receptor 55; G protein-coupled receptor 55, isoform CRA_a; cDNA FLJ75410, highly similar to Homo sapiens G protein-coupled receptor 55, mRNA
GO:0004930[G protein-coupled receptor activity] GO:0004949[cannabinoid receptor activity] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0035025[positive regulation of Rho protein signal transduction] GO:0038171[cannabinoid signaling pathway] GO:0045453[bone resorption] GO:0045671[negative regulation of osteoclast differentiation] GO:0051482[positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway] GO:0070374[positive regulation of ERK1 and ERK2 cascade]
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