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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q25.1
Chromosome location (bp)
173931084 - 174022357
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs 1,2. Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) 3,4. miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression 5,6. Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains 7. Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains 8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
RNA-binding, Transferase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0000288[nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000932[P-body] GO:0000956[nuclear-transcribed mRNA catabolic process] GO:0002634[regulation of germinal center formation] GO:0002635[negative regulation of germinal center formation] GO:0003723[RNA binding] GO:0003725[double-stranded RNA binding] GO:0003729[mRNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008270[zinc ion binding] GO:0010494[cytoplasmic stress granule] GO:0010608[post-transcriptional regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0030889[negative regulation of B cell proliferation] GO:0033962[P-body assembly] GO:0035198[miRNA binding] GO:0035613[RNA stem-loop binding] GO:0042129[regulation of T cell proliferation] GO:0043488[regulation of mRNA stability] GO:0045623[negative regulation of T-helper cell differentiation] GO:0046007[negative regulation of activated T cell proliferation] GO:0046872[metal ion binding] GO:0050852[T cell receptor signaling pathway] GO:0050856[regulation of T cell receptor signaling pathway] GO:0050863[regulation of T cell activation] GO:0061014[positive regulation of mRNA catabolic process] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0061630[ubiquitin protein ligase activity] GO:0071347[cellular response to interleukin-1] GO:1900151[regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1905762[CCR4-NOT complex binding] GO:2000320[negative regulation of T-helper 17 cell differentiation] GO:2000628[regulation of miRNA metabolic process]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0000288[nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000932[P-body] GO:0000956[nuclear-transcribed mRNA catabolic process] GO:0002634[regulation of germinal center formation] GO:0002635[negative regulation of germinal center formation] GO:0003723[RNA binding] GO:0003725[double-stranded RNA binding] GO:0003729[mRNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008270[zinc ion binding] GO:0010494[cytoplasmic stress granule] GO:0010608[post-transcriptional regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0030889[negative regulation of B cell proliferation] GO:0033962[P-body assembly] GO:0035198[miRNA binding] GO:0035613[RNA stem-loop binding] GO:0042129[regulation of T cell proliferation] GO:0043488[regulation of mRNA stability] GO:0045623[negative regulation of T-helper cell differentiation] GO:0046007[negative regulation of activated T cell proliferation] GO:0046872[metal ion binding] GO:0050852[T cell receptor signaling pathway] GO:0050856[regulation of T cell receptor signaling pathway] GO:0050863[regulation of T cell activation] GO:0061014[positive regulation of mRNA catabolic process] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0061630[ubiquitin protein ligase activity] GO:0071347[cellular response to interleukin-1] GO:1900151[regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1905762[CCR4-NOT complex binding] GO:2000320[negative regulation of T-helper 17 cell differentiation] GO:2000628[regulation of miRNA metabolic process]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0000288[nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000932[P-body] GO:0000956[nuclear-transcribed mRNA catabolic process] GO:0001782[B cell homeostasis] GO:0002634[regulation of germinal center formation] GO:0002635[negative regulation of germinal center formation] GO:0003723[RNA binding] GO:0003725[double-stranded RNA binding] GO:0003729[mRNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010494[cytoplasmic stress granule] GO:0010608[post-transcriptional regulation of gene expression] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0030889[negative regulation of B cell proliferation] GO:0033962[P-body assembly] GO:0035198[miRNA binding] GO:0035613[RNA stem-loop binding] GO:0042098[T cell proliferation] GO:0042129[regulation of T cell proliferation] GO:0043029[T cell homeostasis] GO:0043488[regulation of mRNA stability] GO:0045623[negative regulation of T-helper cell differentiation] GO:0046007[negative regulation of activated T cell proliferation] GO:0046872[metal ion binding] GO:0048535[lymph node development] GO:0048536[spleen development] GO:0050852[T cell receptor signaling pathway] GO:0050856[regulation of T cell receptor signaling pathway] GO:0050863[regulation of T cell activation] GO:0061014[positive regulation of mRNA catabolic process] GO:0061158[3'-UTR-mediated mRNA destabilization] GO:0061470[T follicular helper cell differentiation] GO:0061630[ubiquitin protein ligase activity] GO:0071347[cellular response to interleukin-1] GO:1900151[regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1905762[CCR4-NOT complex binding] GO:2000320[negative regulation of T-helper 17 cell differentiation] GO:2000628[regulation of miRNA metabolic process]
The Human Protein Atlas project is funded
