GENERAL INFORMATIONi
Gene namei ANXA1
Synonyms ANX1, LPC1
Gene descriptioni Annexin A1
Protein classi Cancer-related genes
FDA approved drug targets
Plasma proteins
Transporters
Predicted locationi Secreted, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 9
Cytoband q21.13
Chromosome location (bp) 73151865 - 73170393
Number of transcriptsi 4
Ensembl ENSG00000135046 (version 109)
Entrez gene 301
HGNC HGNC:533
UniProt P04083 (UniProt - Evidence at protein level)
neXtProt NX_P04083
GeneCards ANXA1
Antibodypedia ANXA1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity 1. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells 2. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells 3. Has no effect on unstimulated T cells 4. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton 5. Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes 6, 7. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). show less
Molecular function (UniProt)i Phospholipase A2 inhibitor
Biological process (UniProt)i Adaptive immunity, Immunity, Inflammatory response, Innate immunity
Ligand (UniProt)i Calcium, Calcium/phospholipid-binding, Metal-binding
Gene summary (Entrez)i This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
ANXA1-201
ENSP00000257497
ENST00000257497
P04083
[Direct mapping] Annexin A1 Annexin Ac2-26
Show all
Q5TZZ9
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0001780 [neutrophil homeostasis]
GO:0001891 [phagocytic cup]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002548 [monocyte chemotaxis]
GO:0002685 [regulation of leukocyte migration]
GO:0004859 [phospholipase inhibitor activity]
GO:0005102 [signaling receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005929 [cilium]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007187 [G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010165 [response to X-ray]
GO:0014839 [myoblast migration involved in skeletal muscle regeneration]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0018149 [peptide cross-linking]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0019898 [extrinsic component of membrane]
GO:0030073 [insulin secretion]
GO:0030216 [keratinocyte differentiation]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030850 [prostate gland development]
GO:0031018 [endocrine pancreas development]
GO:0031232 [extrinsic component of external side of plasma membrane]
GO:0031313 [extrinsic component of endosome membrane]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031394 [positive regulation of prostaglandin biosynthetic process]
GO:0031410 [cytoplasmic vesicle]
GO:0031514 [motile cilium]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031901 [early endosome membrane]
GO:0031982 [vesicle]
GO:0032355 [response to estradiol]
GO:0032508 [DNA duplex unwinding]
GO:0032652 [regulation of interleukin-1 production]
GO:0032717 [negative regulation of interleukin-8 production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0033031 [positive regulation of neutrophil apoptotic process]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0042063 [gliogenesis]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042119 [neutrophil activation]
GO:0042127 [regulation of cell population proliferation]
GO:0042383 [sarcolemma]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043227 [membrane-bounded organelle]
GO:0043434 [response to peptide hormone]
GO:0045087 [innate immune response]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045629 [negative regulation of T-helper 2 cell differentiation]
GO:0045920 [negative regulation of exocytosis]
GO:0046632 [alpha-beta T cell differentiation]
GO:0046872 [metal ion binding]
GO:0046883 [regulation of hormone secretion]
GO:0048306 [calcium-dependent protein binding]
GO:0050482 [arachidonic acid secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051179 [localization]
GO:0051238 [sequestering of metal ion]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070365 [hepatocyte differentiation]
GO:0070459 [prolactin secretion]
GO:0070555 [response to interleukin-1]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0071621 [granulocyte chemotaxis]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090303 [positive regulation of wound healing]
GO:0097350 [neutrophil clearance]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1900138 [negative regulation of phospholipase A2 activity]
Show all
 346 aa
38.7 kDa 		No 0
ANXA1-202
ENSP00000366109
ENST00000376911
P04083
[Direct mapping] Annexin A1 Annexin Ac2-26
Show all
Q5TZZ9
[Target identity:100%; Query identity:100%] Annexin
Show all
Transporters
   Transporter channels and pores
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0001780 [neutrophil homeostasis]
GO:0001891 [phagocytic cup]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0002548 [monocyte chemotaxis]
GO:0002685 [regulation of leukocyte migration]
GO:0004859 [phospholipase inhibitor activity]
GO:0005102 [signaling receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005929 [cilium]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007187 [G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010165 [response to X-ray]
GO:0014839 [myoblast migration involved in skeletal muscle regeneration]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0018149 [peptide cross-linking]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0019898 [extrinsic component of membrane]
GO:0030073 [insulin secretion]
GO:0030216 [keratinocyte differentiation]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030850 [prostate gland development]
GO:0031018 [endocrine pancreas development]
GO:0031232 [extrinsic component of external side of plasma membrane]
GO:0031313 [extrinsic component of endosome membrane]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031394 [positive regulation of prostaglandin biosynthetic process]
GO:0031410 [cytoplasmic vesicle]
GO:0031514 [motile cilium]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031901 [early endosome membrane]
GO:0031982 [vesicle]
GO:0032355 [response to estradiol]
GO:0032508 [DNA duplex unwinding]
GO:0032652 [regulation of interleukin-1 production]
GO:0032717 [negative regulation of interleukin-8 production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0033031 [positive regulation of neutrophil apoptotic process]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0042063 [gliogenesis]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042119 [neutrophil activation]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043227 [membrane-bounded organelle]
GO:0043434 [response to peptide hormone]
GO:0045087 [innate immune response]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045629 [negative regulation of T-helper 2 cell differentiation]
GO:0045920 [negative regulation of exocytosis]
GO:0046632 [alpha-beta T cell differentiation]
GO:0046872 [metal ion binding]
GO:0046883 [regulation of hormone secretion]
GO:0048306 [calcium-dependent protein binding]
GO:0050482 [arachidonic acid secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051179 [localization]
GO:0051238 [sequestering of metal ion]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070365 [hepatocyte differentiation]
GO:0070459 [prolactin secretion]
GO:0070555 [response to interleukin-1]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0071621 [granulocyte chemotaxis]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090303 [positive regulation of wound healing]
GO:0097350 [neutrophil clearance]
GO:0098609 [cell-cell adhesion]
GO:0098641 [cadherin binding involved in cell-cell adhesion]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1900138 [negative regulation of phospholipase A2 activity]
Show all
 346 aa
38.7 kDa 		No 0
ANXA1-203
ENSP00000414013
ENST00000415424
Q5T3N0
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0002250 [adaptive immune response]
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0042995 [cell projection]
GO:0043227 [membrane-bounded organelle]
Show all
 115 aa
12.6 kDa 		No 0
ANXA1-204
ENSP00000412489
ENST00000456643
Q5T3N1
[Direct mapping] Annexin
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0002250 [adaptive immune response]
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0042995 [cell projection]
GO:0043227 [membrane-bounded organelle]
Show all
 204 aa
22.8 kDa 		No 0

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