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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins RAS pathway related proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q24.3
Chromosome location (bp)
128458761 - 128587558
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription factor 1,2. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts 3. May control the differentiation, survival and proliferation of lymphoid cells 4. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion 5,6....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006955[immune response] GO:0008285[negative regulation of cell population proliferation] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030374[nuclear receptor coactivator activity] GO:0030578[PML body organization] GO:0042802[identical protein binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043565[sequence-specific DNA binding] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045765[regulation of angiogenesis] GO:0045766[positive regulation of angiogenesis] GO:0045786[negative regulation of cell cycle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048870[cell motility] GO:0050729[positive regulation of inflammatory response] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:1902895[positive regulation of miRNA transcription] GO:1904996[positive regulation of leukocyte adhesion to vascular endothelial cell] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006955[immune response] GO:0008285[negative regulation of cell population proliferation] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030374[nuclear receptor coactivator activity] GO:0030578[PML body organization] GO:0042802[identical protein binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043565[sequence-specific DNA binding] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045765[regulation of angiogenesis] GO:0045766[positive regulation of angiogenesis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048870[cell motility] GO:0050729[positive regulation of inflammatory response] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:1902895[positive regulation of miRNA transcription] GO:1904996[positive regulation of leukocyte adhesion to vascular endothelial cell] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006955[immune response] GO:0008285[negative regulation of cell population proliferation] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030374[nuclear receptor coactivator activity] GO:0030578[PML body organization] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043565[sequence-specific DNA binding] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045765[regulation of angiogenesis] GO:0045766[positive regulation of angiogenesis] GO:0045786[negative regulation of cell cycle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046677[response to antibiotic] GO:0048870[cell motility] GO:0050729[positive regulation of inflammatory response] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:1902895[positive regulation of miRNA transcription] GO:1904996[positive regulation of leukocyte adhesion to vascular endothelial cell] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006955[immune response] GO:0008285[negative regulation of cell population proliferation] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030374[nuclear receptor coactivator activity] GO:0030578[PML body organization] GO:0042802[identical protein binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043565[sequence-specific DNA binding] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045765[regulation of angiogenesis] GO:0045766[positive regulation of angiogenesis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048870[cell motility] GO:0050729[positive regulation of inflammatory response] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:1902895[positive regulation of miRNA transcription] GO:1904996[positive regulation of leukocyte adhesion to vascular endothelial cell] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0003676[nucleic acid binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006955[immune response] GO:0008285[negative regulation of cell population proliferation] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030374[nuclear receptor coactivator activity] GO:0030578[PML body organization] GO:0042802[identical protein binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043565[sequence-specific DNA binding] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045765[regulation of angiogenesis] GO:0045766[positive regulation of angiogenesis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048870[cell motility] GO:0050729[positive regulation of inflammatory response] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:1902895[positive regulation of miRNA transcription] GO:1904996[positive regulation of leukocyte adhesion to vascular endothelial cell] GO:1990837[sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700[DNA-binding transcription factor activity] GO:0006357[regulation of transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding]
The Human Protein Atlas project is funded
