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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
REG4 is not prognostic in Pancreatic Adenocarcinoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
768.1
Number of samples
176
Samples
Sample
Description
TPM
TCGA-FB-AAPP-01A
0 years, male, white, stage:Stage IIB, dead, 485 days
26304.8
TCGA-HZ-A8P1-01A
0 years, male, white, stage:Stage IB, alive, 7 days
17065.3
TCGA-US-A776-01A
0 years, male, white, stage:Stage IIA, alive, 1216 days
14468.7
TCGA-HZ-7289-01A
0 years, male, white, stage:Stage IIB, dead, 661 days
11763.8
TCGA-F2-6879-01A
0 years, male, white, stage:Stage IIB, dead, 334 days
4093.3
TCGA-FB-AAPU-01A
0 years, female, asian, stage:Stage IIA, dead, 381 days
3890.0
TCGA-HZ-7919-01A
0 years, female, white, stage:Stage IIB, dead, 593 days
3723.1
TCGA-PZ-A5RE-01A
0 years, female, white, stage:Stage IIB, dead, 470 days
3378.4
TCGA-2J-AAB1-01A
0 years, male, white, stage:Stage IIB, dead, 66 days
3343.7
TCGA-YY-A8LH-01A
0 years, female, white, stage:Stage IIB, alive, 2016 days
3281.5
TCGA-S4-A8RM-01A
0 years, male, white, stage:Stage IIB, alive, 737 days
3240.8
TCGA-FB-AAQ0-01A
0 years, male, white, stage:Stage IIA, dead, 473 days
3076.7
TCGA-IB-7886-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
2991.9
TCGA-IB-AAUU-01A
0 years, male, white, stage:Stage IIB, alive, 245 days
2453.2
TCGA-S4-A8RP-01A
0 years, female, white, stage:Stage IIB, dead, 702 days
2204.5
TCGA-FB-A78T-01A
0 years, female, white, stage:Stage IIB, dead, 375 days
2156.8
TCGA-HZ-7924-01A
0 years, female, white, stage:Stage IIA, alive, 840 days
1852.0
TCGA-HZ-A4BK-01A
0 years, male, white, stage:Stage IIB, alive, 657 days
1685.6
TCGA-HZ-8315-01A
0 years, female, white, stage:Stage IIA, dead, 299 days
1281.9
TCGA-FB-AAPQ-01A
0 years, male, white, stage:Stage IIB, dead, 1130 days
1262.3
TCGA-IB-8127-01A
0 years, male, white, stage:Stage IIB, alive, 522 days
1214.4
TCGA-HZ-A77P-01A
0 years, male, white, stage:Stage IIB, alive, 330 days
1145.7
TCGA-FB-AAQ3-01A
0 years, female, white, stage:Stage IIB, dead, 31 days
1067.6
TCGA-IB-7644-01A
0 years, female, white, stage:Stage IV, dead, 394 days
883.3
TCGA-2L-AAQI-01A
0 years, male, white, stage:Stage IIB, dead, 103 days
851.4
TCGA-H6-A45N-01A
0 years, female, white, stage:Stage IIB, dead, 397 days
746.9
TCGA-2J-AAB8-01A
0 years, male, white, stage:Stage IIB, alive, 80 days
591.6
TCGA-YB-A89D-01A
0 years, male, white, stage:Stage IIB, alive, 350 days
549.3
TCGA-HZ-8638-01A
0 years, female, white, stage:Stage IA, dead, 151 days
535.1
TCGA-FB-AAPY-01A
0 years, male, white, stage:Stage IIB, dead, 1059 days
492.9
TCGA-HV-A5A5-01A
0 years, female, asian, stage:Stage IIB, alive, 289 days
485.1
TCGA-XD-AAUI-01A
0 years, female, white, stage:Stage IIB, dead, 366 days
480.5
TCGA-3A-A9J0-01A
0 years, male, white, stage:Stage IIB, alive, 743 days
468.8
TCGA-IB-A7M4-01A
0 years, male, white, stage:Stage IIB, alive, 483 days
460.5
TCGA-HZ-7922-01A
0 years, female, white, stage:Stage IIB, alive, 4 days
454.7
TCGA-2J-AABF-01A
0 years, male, white, stage:Stage IIB, dead, 691 days
416.0
TCGA-IB-7889-01A
0 years, female, white, stage:Stage IIB, dead, 481 days
391.9
TCGA-US-A77E-01A
0 years, male, white, stage:Stage IIB, dead, 430 days
371.0
TCGA-IB-AAUT-01A
0 years, male, white, stage:Stage IIB, alive, 287 days
332.6
TCGA-HV-A7OL-01A
0 years, male, asian, stage:Stage IIA, alive, 252 days
330.5
TCGA-IB-A5SO-01A
0 years, male, white, stage:Stage IIB, dead, 365 days
308.3
TCGA-HV-A5A4-01A
0 years, female, asian, stage:Stage IIA, alive, 232 days
303.7
TCGA-HZ-8317-01A
0 years, female, white, stage:Stage IIB, dead, 378 days
298.1
TCGA-IB-7649-01A
0 years, female, stage:Stage IIB, dead, 467 days
291.7
TCGA-FB-AAPZ-01A
0 years, male, white, stage:Stage IIB, alive, 716 days
290.4
TCGA-HZ-A4BH-01A
0 years, male, white, stage:Stage IIB, alive, 194 days
289.2
TCGA-F2-A44G-01A
0 years, female, white, stage:Stage IIB, dead, 233 days
288.0
TCGA-LB-A8F3-01A
0 years, female, black or african american, stage:Stage IIA, alive, 379 days
285.5
TCGA-Q3-AA2A-01A
0 years, female, white, stage:Stage IB, alive, 95 days
273.4
TCGA-2J-AABK-01A
0 years, male, white, stage:Stage IIB, alive, 484 days
271.8
TCGA-IB-7645-01A
0 years, female, stage:Stage IIB, dead, 1502 days
258.7
TCGA-IB-AAUR-01A
0 years, male, white, stage:Stage IIB, alive, 338 days
252.3
TCGA-2J-AABH-01A
0 years, male, white, stage:Stage IIA, alive, 1287 days
237.2
TCGA-2L-AAQE-01A
0 years, male, white, stage:Stage IIB, dead, 684 days
235.5
TCGA-2J-AABE-01A
0 years, male, white, stage:Stage IIA, alive, 676 days
230.5
TCGA-2L-AAQJ-01A
0 years, female, white, stage:Stage III, dead, 394 days
223.7
TCGA-HZ-A9TJ-01A
0 years, male, white, stage:Stage IV, alive, 603 days
214.4
TCGA-OE-A75W-01A
0 years, male, white, stage:Stage IIA, dead, 267 days
208.3
TCGA-HZ-8636-01A
0 years, female, white, stage:Stage IV, dead, 545 days
190.7
TCGA-IB-A5ST-01A
0 years, female, white, stage:Stage IIB, alive, 635 days
182.3
TCGA-3A-A9I7-01A
0 years, male, black or african american, stage:Stage IIB, alive, 1323 days
177.3
TCGA-HZ-A49I-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
170.0
TCGA-HV-A5A6-01A
0 years, female, asian, stage:Stage IIB, dead, 2036 days
147.7
TCGA-IB-AAUQ-01A
0 years, male, white, stage:Stage IIB, dead, 183 days
143.0
TCGA-2L-AAQA-01A
0 years, male, white, stage:Stage IIB, dead, 143 days
140.1
TCGA-HV-A7OP-01A
0 years, male, asian, stage:Stage IIB, alive, 978 days
136.6
TCGA-FB-AAQ6-01A
0 years, male, white, stage:Stage IA, dead, 244 days
134.6
TCGA-US-A77G-01A
0 years, male, white, stage:Stage IIB, dead, 12 days
134.2
TCGA-2J-AABU-01A
0 years, male, white, stage:Stage IIB, dead, 277 days
132.5
TCGA-RB-A7B8-01A
0 years, female, white, stage:Stage IIB, dead, 466 days
130.5
TCGA-IB-7651-01A
0 years, female, white, stage:Stage IIB, dead, 603 days
126.7
TCGA-2J-AABT-01A
0 years, female, white, stage:Stage IIB, alive, 319 days
126.5
TCGA-3A-A9IC-01A
0 years, female, white, stage:Stage IIB, dead, 738 days
125.0
TCGA-IB-AAUP-01A
0 years, male, white, stage:Stage IIB, alive, 431 days
119.0
TCGA-2J-AAB4-01A
0 years, male, white, stage:Stage IIB, alive, 729 days
112.8
TCGA-F2-A8YN-01A
0 years, male, white, stage:Stage IIA, alive, 517 days
111.1
TCGA-HZ-7926-01A
0 years, male, black or african american, stage:Stage IIB, dead, 518 days
108.1
TCGA-2L-AAQL-01A
0 years, male, white, stage:Stage IIB, dead, 292 days
105.8
TCGA-XD-AAUL-01A
0 years, male, white, stage:Stage IIA, alive, 498 days
102.9
TCGA-FB-A4P5-01A
0 years, female, white, stage:Stage IIB, dead, 179 days
94.6
TCGA-US-A779-01A
0 years, female, white, stage:Stage IIB, dead, 511 days
86.7
TCGA-FB-A4P6-01A
0 years, male, white, stage:Stage IIB, alive, 767 days
85.0
TCGA-IB-AAUM-01A
0 years, male, white, stage:Stage IIB, alive, 8 days
79.8
TCGA-S4-A8RO-01A
0 years, female, white, stage:Stage IIB, alive, 525 days
71.4
TCGA-US-A774-01A
0 years, female, white, stage:Stage IIB, dead, 695 days
67.8
TCGA-IB-A5SP-01A
0 years, male, white, stage:Stage IIA, alive, 482 days
66.3
TCGA-HZ-8637-01A
0 years, female, white, stage:Stage IIB, dead, 517 days
63.6
TCGA-HZ-8003-01A
0 years, female, white, stage:Stage IIB, dead, 596 days
59.1
TCGA-2J-AABO-01A
0 years, male, white, stage:Stage IIB, alive, 440 days
59.0
TCGA-HV-AA8X-01A
0 years, female, asian, stage:Stage IIB, dead, 532 days
51.6
TCGA-H8-A6C1-01A
0 years, male, white, stage:Stage IIA, alive, 671 days
49.1
TCGA-HZ-A77Q-01A
0 years, female, white, stage:Stage IIB, alive, 33 days
49.0
TCGA-F2-7276-01A
0 years, male, white, stage:Stage IIB, dead, 216 days
47.7
TCGA-F2-6880-01A
0 years, male, white, stage:Stage IIB, alive, 295 days
47.2
TCGA-HZ-A49G-01A
0 years, female, white, stage:Stage IIB, alive, 660 days
43.8
TCGA-IB-AAUW-01A
0 years, female, white, stage:Stage IIB, dead, 230 days
43.1
TCGA-3E-AAAZ-01A
0 years, male, white, stage:Stage IIA, dead, 2182 days
41.5
TCGA-2J-AAB9-01A
0 years, female, white, stage:Stage IIB, dead, 627 days
37.3
TCGA-3A-A9IX-01A
0 years, male, white, stage:Stage IA, alive, 1037 days
32.5
TCGA-Z5-AAPL-01A
0 years, female, white, stage:Stage IIA, alive, 467 days
31.2
TCGA-IB-7891-01A
0 years, female, white, stage:Stage IIB, dead, 913 days
30.2
TCGA-2J-AABA-01A
0 years, male, white, stage:Stage IIB, dead, 607 days
27.7
TCGA-2J-AABV-01A
0 years, male, white, stage:Stage IIB, dead, 652 days
26.7
TCGA-LB-A9Q5-01A
0 years, female, white, stage:Stage IIB, dead, 313 days
26.2
TCGA-HZ-A49H-01A
0 years, female, white, stage:Stage IIB, alive, 491 days
25.2
TCGA-3A-A9I9-01A
0 years, male, white, stage:Stage IIA, dead, 634 days
24.9
TCGA-IB-AAUO-01A
0 years, female, white, stage:Stage IIB, dead, 239 days
24.7
TCGA-Q3-A5QY-01A
0 years, male, white, stage:Stage IIB, alive, 416 days
24.0
TCGA-3E-AAAY-01A
0 years, male, white, stage:Stage IIB, alive, 2285 days
19.2
TCGA-HZ-A77O-01A
0 years, female, white, stage:Stage IIB, dead, 160 days
18.4
TCGA-FB-A7DR-01A
0 years, male, asian, stage:Stage IIA, dead, 353 days
17.7
TCGA-F2-7273-01A
0 years, male, black or african american, stage:Stage IIB, dead, 592 days
16.3
TCGA-IB-A6UG-01A
0 years, male, white, stage:Stage IIB, dead, 41 days
16.0
TCGA-IB-8126-01A
0 years, female, white, stage:Stage III, alive, 462 days
14.9
TCGA-IB-AAUN-01A
0 years, female, white, stage:Stage IB, dead, 144 days
14.6
TCGA-F2-A44H-01A
0 years, male, white, stage:Stage IIA, alive, 586 days
14.4
TCGA-IB-A5SQ-01A
0 years, female, white, stage:Stage IB, dead, 219 days
14.4
TCGA-IB-7654-01A
0 years, male, white, stage:Stage IIB, dead, 476 days
14.4
TCGA-XD-AAUH-01A
0 years, female, white, stage:Stage IIB, alive, 395 days
14.3
TCGA-XD-AAUG-01A
0 years, female, white, stage:Stage IV, alive, 420 days
14.3
TCGA-3A-A9IL-01A
0 years, female, white, stage:Stage I, alive, 2741 days
12.8
TCGA-HZ-7925-01A
0 years, male, white, stage:Stage IIB, dead, 614 days
11.5
TCGA-IB-AAUS-01A
0 years, female, white, stage:Stage IIB, alive, 225 days
11.0
TCGA-3A-A9IH-01A
0 years, female, white, stage:Stage IA, alive, 1021 days
10.5
TCGA-3A-A9IZ-01A
0 years, male, white, stage:Stage IIB, dead, 308 days
9.6
TCGA-3A-A9IU-01A
0 years, male, white, stage:Stage IIB, dead, 458 days
8.5
TCGA-HZ-7918-01A
0 years, male, white, stage:Stage IIB, alive, 969 days
8.0
TCGA-FB-AAQ2-01A
0 years, female, white, stage:Stage IIB, dead, 153 days
7.1
TCGA-RB-AA9M-01A
0 years, male, white, stage:Stage IIB, alive, 286 days
6.8
TCGA-IB-7890-01A
0 years, male, stage:Stage IB, dead, 598 days
6.8
TCGA-IB-7652-01A
0 years, female, asian, stage:Stage IIB, alive, 1116 days
6.5
TCGA-IB-A6UF-01A
0 years, male, white, stage:Stage IIB, alive, 666 days
6.4
TCGA-F2-A7TX-01A
0 years, male, white, stage:Stage IIB, dead, 95 days
6.2
TCGA-HZ-8002-01A
0 years, male, white, stage:Stage IIB, dead, 366 days
5.9
TCGA-2J-AABR-01A
0 years, female, white, stage:Stage IIA, alive, 438 days
4.5
TCGA-IB-A5SS-01A
0 years, female, white, stage:Stage IIB, dead, 460 days
4.5
TCGA-M8-A5N4-01A
0 years, female, stage:Stage IIA, alive, 584 days
4.2
TCGA-IB-7893-01A
0 years, male, white, stage:Stage IIA, dead, 117 days
4.1
TCGA-IB-7885-01A
0 years, female, white, stage:Stage IIB, alive, 1257 days
4.1
TCGA-XN-A8T3-01A
0 years, male, white, stage:Stage IB, alive, 951 days
3.8
TCGA-3A-A9IB-01A
0 years, female, white, stage:Stage IIB, dead, 224 days
3.5
TCGA-RL-AAAS-01A
0 years, female, white, stage:Stage IB, alive, 9 days
3.4
TCGA-H6-8124-01A
0 years, female, white, stage:Stage IIB, alive, 392 days
3.4
TCGA-HZ-7923-01A
0 years, male, white, stage:Stage IIA, alive, 314 days
2.9
TCGA-HZ-8001-01A
0 years, male, white, stage:Stage III, alive, 706 days
2.7
TCGA-YH-A8SY-01A
0 years, female, white, stage:'--, alive, 388 days
2.6
TCGA-IB-A7LX-01A
0 years, male, white, stage:Stage IIB, dead, 250 days
2.5
TCGA-FB-A545-01A
0 years, female, white, stage:Stage IIB, dead, 732 days
2.2
TCGA-IB-7888-01A
0 years, female, black or african american, stage:Stage IIA, dead, 1332 days
2.1
TCGA-HV-AA8V-01A
0 years, male, asian, stage:Stage IIB, alive, 920 days
2.0
TCGA-3A-A9IV-01A
0 years, female, white, stage:Stage IB, alive, 1103 days
1.7
TCGA-IB-AAUV-01A
0 years, male, white, stage:Stage IIB, alive, 404 days
1.7
TCGA-HZ-7920-01A
0 years, male, white, stage:Stage IB, dead, 236 days
1.6
TCGA-IB-7897-01A
0 years, female, white, stage:Stage IIB, dead, 486 days
1.5
TCGA-HV-A5A3-01A
0 years, male, asian, stage:Stage IIA, dead, 128 days
1.5
TCGA-2L-AAQM-01A
0 years, male, white, stage:Stage IIB, alive, 1383 days
1.4
TCGA-3A-A9IS-01A
0 years, male, white, stage:Stage IB, alive, 998 days
1.4
TCGA-XN-A8T5-01A
0 years, female, white, stage:Stage IB, alive, 720 days
1.2
TCGA-LB-A7SX-01A
0 years, female, black or african american, stage:Stage IIB, dead, 393 days
1.1
TCGA-3A-A9IO-01A
0 years, male, white, stage:'--, alive, 1942 days
0.9
TCGA-FB-A5VM-01A
0 years, male, white, stage:Stage IB, dead, 498 days
0.9
TCGA-HZ-8519-01A
0 years, male, white, stage:Stage IA, alive, 454 days
0.9
TCGA-FB-AAQ1-01A
0 years, male, white, stage:Stage IIB, dead, 123 days
0.8
TCGA-2J-AAB6-01A
0 years, male, white, stage:Stage IIA, dead, 293 days
0.7
TCGA-FB-AAPS-01A
0 years, female, white, stage:Stage IIB, alive, 228 days
0.5
TCGA-3A-A9IN-01A
0 years, female, white, stage:Stage IB, alive, 2084 days
0.5
TCGA-US-A77J-01A
0 years, female, white, stage:Stage IIB, dead, 568 days
0.4
TCGA-3A-A9I5-01A
0 years, male, white, stage:'--, alive, 1794 days
0.2
TCGA-3A-A9IJ-01A
0 years, male, white, stage:Stage IB, alive, 1854 days
0.1
TCGA-IB-7887-01A
0 years, female, white, stage:Stage IIB, dead, 110 days
0.1
TCGA-HZ-8005-01A
0 years, male, white, stage:Stage IIB, dead, 120 days
0.1
TCGA-L1-A7W4-01A
0 years, female, white, stage:Stage IIB, dead, 278 days
0.1
TCGA-IB-7646-01A
0 years, male, white, stage:Stage IIB, dead, 145 days
0.1
TCGA-2J-AABI-01A
0 years, female, white, stage:Stage IIA, alive, 969 days
0.0
TCGA-3A-A9IR-01A
0 years, female, white, stage:Stage IB, alive, 1542 days
0.0
TCGA-2J-AABP-01A
0 years, female, white, stage:Stage IIB, alive, 463 days
The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
REG4 is not prognostic in Pancreatic Adenocarcinoma (validation)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
5-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
5-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
244.1
Number of samples
80
Samples
Sample
Description
TPM
DO33488
0 years, male, NA, stage:, alive, 844 days
2001.9
DO34801
0 years, male, NA, stage:, alive, 626 days
1998.6
DO34817
0 years, female, NA, stage:, alive, 540 days
1750.5
DO34785
0 years, female, NA, stage:, alive, 721 days
1302.5
DO34368
0 years, female, NA, stage:, dead, 537 days
1279.7
DO49087
0 years, female, NA, stage:, dead, 260 days
1183.2
DO33392
0 years, male, NA, stage:, alive, 1014 days
1180.0
DO49127
0 years, female, NA, stage:, alive, 392 days
771.4
DO49113
0 years, female, NA, stage:, alive, 413 days
621.4
DO33344
0 years, male, NA, stage:, dead, 361 days
486.9
DO33984
0 years, male, NA, stage:, alive, 847 days
464.7
DO34696
0 years, male, NA, stage:, alive, 689 days
435.7
DO34793
0 years, male, NA, stage:, dead, 427 days
429.3
DO49078
0 years, male, NA, stage:, dead, 465 days
325.2
DO33544
0 years, female, NA, stage:, dead, 412 days
308.7
DO49129
0 years, male, NA, stage:, alive, 337 days
308.5
DO34680
0 years, male, NA, stage:, dead, 99 days
305.8
DO49133
0 years, female, NA, stage:, alive, 188 days
304.1
DO49164
0 years, male, NA, stage:, alive, 272 days
303.3
DO49137
0 years, female, NA, stage:, alive, 232 days
280.3
DO34264
0 years, female, NA, stage:, dead, 1144 days
272.5
DO49193
0 years, male, NA, stage:, dead, 1 days
271.1
DO49172
0 years, female, NA, stage:, dead, 1021 days
267.0
DO49090
0 years, female, NA, stage:, dead, 152 days
260.9
DO49135
0 years, male, NA, stage:, alive, 270 days
232.0
DO49178
0 years, male, NA, stage:, dead, 27 days
223.7
DO32900
0 years, male, NA, stage:, dead, 768 days
210.1
DO32863
0 years, male, NA, stage:, dead, 715 days
182.3
DO34608
0 years, female, NA, stage:, dead, 709 days
174.4
DO33552
0 years, female, NA, stage:, alive, 873 days
149.5
DO34288
0 years, female, NA, stage:, dead, 220 days
130.8
DO34656
0 years, female, NA, stage:, alive, 834 days
100.9
DO32878
0 years, female, NA, stage:, dead, 260 days
98.8
DO32860
0 years, male, NA, stage:, dead, 1259 days
94.3
DO34448
0 years, female, NA, stage:, dead, 719 days
89.2
DO33512
female, NA, stage:, dead, 499 days
87.1
DO33408
0 years, female, NA, stage:, alive, 909 days
67.8
DO34616
0 years, female, NA, stage:, alive, 666 days
62.3
DO49181
0 years, male, NA, stage:, dead, 1534 days
59.1
DO34720
0 years, male, NA, stage:, alive, 555 days
52.4
DO34849
0 years, female, NA, stage:, dead, 272 days
47.1
DO49184
0 years, male, NA, stage:, dead, 455 days
43.5
DO33472
0 years, female, NA, stage:, dead, 388 days
42.7
DO49130
0 years, female, NA, stage:, alive, 351 days
37.4
DO49185
0 years, male, NA, stage:, alive, 179 days
33.0
DO49076
0 years, male, NA, stage:, dead, 480 days
32.2
DO49138
0 years, male, NA, stage:, dead, 230 days
28.4
DO49183
0 years, female, NA, stage:, dead, 429 days
24.0
DO34432
0 years, female, NA, stage:, dead, 400 days
21.7
DO33376
0 years, female, NA, stage:, alive, 909 days
20.5
DO32875
0 years, male, NA, stage:, dead, 348 days
12.0
DO34504
0 years, male, NA, stage:, dead, 257 days
11.9
DO34961
0 years, male, NA, stage:, dead, 632 days
8.5
DO49175
0 years, male, NA, stage:, dead, 414 days
7.1
DO34736
0 years, female, NA, stage:, dead, 203 days
5.3
DO33336
0 years, female, NA, stage:, dead, 451 days
4.5
DO34312
0 years, female, NA, stage:, dead, 226 days
4.1
DO49198
0 years, female, NA, stage:, dead, 251 days
4.1
DO34809
0 years, female, NA, stage:, dead, 297 days
3.4
DO33480
0 years, male, NA, stage:, alive, 1054 days
2.3
DO34600
0 years, male, NA, stage:, dead, 537 days
1.3
DO49074
0 years, male, NA, stage:, dead, 168 days
1.2
DO34240
0 years, male, NA, stage:, dead, 236 days
1.2
DO34728
0 years, female, NA, stage:, alive, 508 days
1.0
DO33128
0 years, male, NA, stage:, dead, 423 days
1.0
DO49080
0 years, male, NA, stage:, alive, 83 days
0.9
DO32829
0 years, female, NA, stage:T2N0MX, dead, 1874 days
0.9
DO34640
0 years, female, NA, stage:, dead, 287 days
0.8
DO33400
0 years, female, NA, stage:, alive, 1043 days
0.6
DO49168
0 years, male, NA, stage:, alive, 149 days
0.6
DO49199
0 years, male, NA, stage:, dead, 1095 days
0.6
DO34905
0 years, male, NA, stage:, alive, 1142 days
0.5
DO49166
0 years, female, NA, stage:, alive, 222 days
0.4
DO33600
0 years, female, NA, stage:, alive, 854 days
0.4
DO33368
0 years, male, NA, stage:, dead, 98 days
0.3
DO49170
0 years, male, NA, stage:, alive, 197 days
0.2
DO49079
0 years, male, NA, stage:, dead, 332 days
0.2
DO49204
0 years, male, NA, stage:, dead, 156 days
0.1
DO33168
0 years, female, NA, stage:, dead, 8 days
0.1
DO34336
0 years, female, NA, stage:, alive, 743 days
0.0
Show allShow less
PANCREATIC DUCTAL ADENOCARCINOMA - Protein relative expression (CPTAC)
Number of samples
235
Samples
Sample ID
Sample type
nRPX
CPT0241500004
Tumor
2.8
CPT0081470004
Tumor
2.7
CPT0246940003
Tumor
2.5
CPT0247090003
Tumor
2.4
CPT0087890004
Tumor
2.1
CPT0025750003
Tumor
1.9
CPT0094940004
Tumor
1.9
CPT0209310004
Tumor
1.8
CPT0000250017
Tumor
1.5
CPT0109200004
Tumor
1.5
CPT0226530004
Tumor
1.5
CPT0109300004
Tumor
1.2
CPT0011520003
Tumor
1.2
CPT0187550004
Tumor
1.1
CPT0108930003
Tumor
1.1
CPT0236700005
Tumor
1.1
CPT0014040003
Tumor
1.0
CPT0078250003
Tumor
1.0
CPT0124410004
Tumor
0.8
CPT0127270003
Tumor
0.7
CPT0226760004
Tumor
0.7
CPT0347820002
Normal
0.7
CPT0081260004
Tumor
0.6
CPT0093980004
Tumor
0.6
CPT0246840003
Tumor
0.6
CPT0238920004
Tumor
0.5
CPT0161770004
Tumor
0.4
CPT0246950003
Normal
0.4
KoreanReference2
Tumor
0.3
CPT0174700004
Tumor
0.3
CPT0238440005
Tumor
0.3
KoreanReference3
Tumor
0.2
KoreanReference1
Tumor
0.1
CPT0203850004
Tumor
0.1
CPT0089720003
Tumor
0.0
CPT0246260004
Tumor
0.0
CPT0183450005
Tumor
0.0
CPT0224460004
Tumor
-0.1
CPT0186040004
Tumor
-0.1
CPT0236560004
Tumor
-0.1
CPT0123890003
Normal
-0.2
CPT0078000003
Tumor
-0.2
CPT0237850004
Normal
-0.2
CPT0238530005
Tumor
-0.3
CPT0264150003
Tumor
-0.3
CPT0238740004
Normal
-0.4
CPT0123460003
Normal
-0.4
CPT0064520004
Tumor
-0.4
CPT0236340004
Tumor
-0.5
CPT0077860003
Tumor
-0.5
CPT0127290003
Normal
-0.5
CPT0162780004
Normal
-0.5
CPT0226610004
Normal
-0.5
CPT0187930005
Tumor
-0.5
CPT0238710004
Tumor
-0.5
CPT0235230004
Tumor
-0.6
CPT0065570003
Tumor
-0.6
CPT0226680005
Tumor
-0.6
CPT0063970004
Tumor
-0.6
CPT0025760003
Normal
-0.6
CPT0124000003
Normal
-0.6
CPT0237840004
Tumor
-0.6
CPT0093880003
Normal
-0.6
CPT0241320005
Tumor
-0.7
CPT0138990003
Normal
-0.7
CPT0108960003
Normal
-0.7
CPT0094630004
Tumor
-0.7
CPT0166780004
Normal
-0.7
CPT0218200004
Tumor
-0.7
CPT0123860003
Tumor
-0.7
C3L-03632-04
Normal
-0.7
CPT0017040004
Tumor
-0.7
CPT0162660004
Tumor
-0.7
CPT0208710004
Normal
-0.7
CPT0011540003
Normal
-0.7
CPT0197420004
Tumor
-0.7
CPT0086210003
Normal
-0.7
CPT0063570003
Tumor
-0.7
CPT0208690004
Tumor
-0.7
CPT0237920004
Normal
-0.8
CPT0226570004
Tumor
-0.8
CPT0077880003
Normal
-0.8
CPT0064110003
Normal
-0.8
CPT0094230004
Tumor
-0.8
CPT0093860003
Tumor
-0.9
CPT0185920004
Tumor
-0.9
CPT0123990003
Tumor
-0.9
CPT0248590004
Tumor
-0.9
CPT0248410004
Tumor
-0.9
CPT0108400003
Tumor
-0.9
CPT0008750003
Tumor
-0.9
CPT0198700005
Tumor
-0.9
CPT0139000004
Tumor
-0.9
CPT0166760004
Tumor
-0.9
CPT0094180003
Tumor
-0.9
CPT0236360004
Normal
-0.9
CPT0198420004
Tumor
-0.9
CPT0125090003
Tumor
-1.0
CPT0248620003
Normal
-1.0
CPT0227930004
Tumor
-1.0
CPT0198910005
Tumor
-1.0
CPT0238820005
Tumor
-1.0
CPT0125130003
Tumor
-1.0
CPT0088260004
Tumor
-1.0
CPT0209640005
Tumor
-1.0
CPT0017130003
Normal
-1.0
CPT0081060004
Tumor
-1.0
CPT0218220004
Normal
-1.0
CPT0197440004
Normal
-1.0
CPT0236780005
Tumor
-1.0
CPT0019410004
Tumor
-1.1
CPT0078090004
Tumor
-1.1
CPT0347790002
Normal
-1.1
CPT0207780004
Tumor
-1.1
CPT0241510004
Normal
-1.1
CPT0064090003
Tumor
-1.1
CPT0347850002
Normal
-1.1
CPT0246210004
Tumor
-1.1
WU-PDA1
Tumor
-1.1
CPT0086190004
Tumor
-1.1
CPT0077810003
Normal
-1.1
CPT0008800003
Tumor
-1.2
CPT0078180003
Normal
-1.2
CPT0183750005
Tumor
-1.2
CPT0208550005
Tumor
-1.2
CPT0092630003
Tumor
-1.2
CPT0001730017
Tumor
-1.2
CPT0088320003
Tumor
-1.2
CPT0162760003
Tumor
-1.2
CPT0063580003
Normal
-1.2
CPT0198930003
Normal
-1.3
CPT0187540004
Normal
-1.3
CPT0078160004
Tumor
-1.3
CPT0237910004
Tumor
-1.3
CPT0198440004
Normal
-1.3
CPT0170260004
Normal
-1.3
CPT0089750004
Normal
-1.3
CPT0066020003
Normal
-1.3
CPT0247000003
Normal
-1.3
CPT0226650004
Tumor
-1.4
CPT0091660003
Tumor
-1.4
CPT0174800003
Normal
-1.4
CPT0109010004
Tumor
-1.4
CPT0088180004
Tumor
-1.4
CPT0236800004
Normal
-1.4
CPT0355180003
Normal
-1.5
CPT0124610004
Tumor
-1.5
C3L-00189-04
Normal
-1.5
CPT0246220004
Normal
-1.5
CPT0246720003
Tumor
-1.5
CPT0077790004
Tumor
-1.5
CPT0207990004
Normal
-1.5
CPT0019300004
Tumor
-1.5
C3N-02573-03
Normal
-1.6
CPT0209650004
Normal
-1.6
CPT0226600004
Tumor
-1.6
C3L-00401-04
Normal
-1.6
CPT0091680003
Normal
-1.6
CPT0246990003
Tumor
-1.6
CPT0126160004
Tumor
-1.6
CPT0123670003
Normal
-1.6
CPT0078030003
Normal
-1.6
CPT0208850004
Normal
-1.6
CPT0123440003
Tumor
-1.6
CPT0207980005
Tumor
-1.7
CPT0347760002
Normal
-1.7
CPT0239920004
Normal
-1.7
CPT0247040003
Tumor
-1.7
CPT0162670004
Normal
-1.8
CPT0161990005
Tumor
-1.8
CPT0183770004
Normal
-1.8
CPT0208840004
Tumor
-1.8
CPT0170240004
Tumor
-1.8
C3N-00709-06
Normal
-1.8
CPT0246810003
Tumor
-1.8
CPT0123750003
Tumor
-1.8
CPT0238940004
Normal
-1.8
CPT0276030003
Normal
-1.8
CPT0355200003
Normal
-1.9
CPT0123650003
Tumor
-1.9
CPT0123770003
Normal
-1.9
CPT0094130004
Tumor
-1.9
CPT0124360003
Tumor
-1.9
CPT0081360004
Tumor
-1.9
CPT0248440003
Normal
-1.9
CPT0094740004
Tumor
-1.9
CPT0355190003
Normal
-1.9
CPT0236710004
Normal
-2.0
CPT0254680003
Tumor
-2.0
CPT0221470005
Tumor
-2.0
CPT0064570003
Normal
-2.0
CPT0276010003
Tumor
-2.0
CPT0065640003
Tumor
-2.1
CPT0239910004
Tumor
-2.1
CPT0093930004
Tumor
-2.1
CPT0124500004
Tumor
-2.2
CPT0094030003
Tumor
-2.2
CPT0238040005
Tumor
-2.2
CPT0124530003
Normal
-2.3
CPT0217700004
Tumor
-2.3
CPT0347880002
Normal
-2.4
CPT0001750003
Normal
-2.4
CPT0239100009
Tumor
-2.4
CPT0083270003
Tumor
-2.4
CPT0221250004
Normal
-2.5
CPT0077950003
Normal
-2.6
CPT0077930004
Tumor
-2.6
CPT0226490004
Tumor
-2.7
CPT0238640004
Normal
-2.7
CPT0221240004
Tumor
-2.7
CPT0124980004
Tumor
-2.7
CPT0238610009
Tumor
-2.9
CPT0237270005
Tumor
-3.0
CPT0125010003
Normal
-3.4
CPT0239140004
Normal
-3.5
CPT0247050003
Normal
N/A
CPT0108410003
Normal
N/A
CPT0248320003
Normal
N/A
CPT0166650006
Tumor
N/A
CPT0224470004
Normal
N/A
C3L-01687-04
Normal
N/A
CPT0138890003
Normal
N/A
CPT0109110004
Tumor
N/A
WU-pooled sample
Tumor
N/A
CPT0014060003
Normal
N/A
CPT0109130003
Normal
N/A
CPT0138900004
Tumor
N/A
CPT0166680004
Normal
N/A
CPT0094760003
Normal
N/A
CPT0186050004
Normal
N/A
CPT0237290004
Normal
N/A
CPT0264180003
Normal
N/A
CPT0063990003
Normal
N/A
CPT0126200003
Normal
N/A
CPT0198730004
Normal
N/A
Show allShow less
PANCREATIC CANCER - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
The Human Protein Atlas project is funded
