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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p13.3
Chromosome location (bp)
109603091 - 109619929
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transducer
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Sensory transduction, Vision
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000166[nucleotide binding] GO:0001580[detection of chemical stimulus involved in sensory perception of bitter taste] GO:0001664[G protein-coupled receptor binding] GO:0001750[photoreceptor outer segment] GO:0001917[photoreceptor inner segment] GO:0003924[GTPase activity] GO:0005525[GTP binding] GO:0005834[heterotrimeric G-protein complex] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007188[adenylate cyclase-modulating G protein-coupled receptor signaling pathway] GO:0007601[visual perception] GO:0007602[phototransduction] GO:0008020[G protein-coupled photoreceptor activity] GO:0016020[membrane] GO:0019001[guanyl nucleotide binding] GO:0031683[G-protein beta/gamma-subunit complex binding] GO:0042622[photoreceptor outer segment membrane] GO:0042995[cell projection] GO:0046872[metal ion binding] GO:0050896[response to stimulus] GO:0050908[detection of light stimulus involved in visual perception]
Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Eye disease Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000166[nucleotide binding] GO:0001580[detection of chemical stimulus involved in sensory perception of bitter taste] GO:0001664[G protein-coupled receptor binding] GO:0001750[photoreceptor outer segment] GO:0001917[photoreceptor inner segment] GO:0003924[GTPase activity] GO:0005525[GTP binding] GO:0005834[heterotrimeric G-protein complex] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007188[adenylate cyclase-modulating G protein-coupled receptor signaling pathway] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0007601[visual perception] GO:0007602[phototransduction] GO:0008020[G protein-coupled photoreceptor activity] GO:0009642[response to light intensity] GO:0016020[membrane] GO:0019001[guanyl nucleotide binding] GO:0031683[G-protein beta/gamma-subunit complex binding] GO:0042622[photoreceptor outer segment membrane] GO:0042995[cell projection] GO:0046549[retinal cone cell development] GO:0046872[metal ion binding] GO:0050896[response to stimulus] GO:0050908[detection of light stimulus involved in visual perception]
The Human Protein Atlas project is funded
