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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q22.3
Chromosome location (bp)
79937467 - 79982614
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Gaseous exchange, Immunity, Innate immunity
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Lectin
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P35247 [Direct mapping] Pulmonary surfactant-associated protein D
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001817[regulation of cytokine production] GO:0002376[immune system process] GO:0002682[regulation of immune system process] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005581[collagen trimer] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005771[multivesicular body] GO:0005789[endoplasmic reticulum membrane] GO:0005791[rough endoplasmic reticulum] GO:0006898[receptor-mediated endocytosis] GO:0007585[respiratory gaseous exchange by respiratory system] GO:0030139[endocytic vesicle] GO:0030246[carbohydrate binding] GO:0032703[negative regulation of interleukin-2 production] GO:0042130[negative regulation of T cell proliferation] GO:0042742[defense response to bacterium] GO:0042802[identical protein binding] GO:0043129[surfactant homeostasis] GO:0043152[induction of bacterial agglutination] GO:0045087[innate immune response] GO:0045334[clathrin-coated endocytic vesicle] GO:0048246[macrophage chemotaxis] GO:0048286[lung alveolus development] GO:0050766[positive regulation of phagocytosis] GO:0052403[negative regulation by host of symbiont catalytic activity] GO:0072593[reactive oxygen species metabolic process] GO:1905226[regulation of adhesion of symbiont to host epithelial cell]
The Human Protein Atlas project is funded
