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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.3
Chromosome location (bp)
1762029 - 1777565
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A0A140VKF3 [Target identity:100%; Query identity:100%] Testis tissue sperm-binding protein Li 70n
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001822[kidney development] GO:0004867[serine-type endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005604[basement membrane] GO:0005615[extracellular space] GO:0007568[aging] GO:0007614[short-term memory] GO:0010447[response to acidic pH] GO:0010596[negative regulation of endothelial cell migration] GO:0010629[negative regulation of gene expression] GO:0010951[negative regulation of endopeptidase activity] GO:0010976[positive regulation of neuron projection development] GO:0014070[response to organic cyclic compound] GO:0016525[negative regulation of angiogenesis] GO:0030424[axon] GO:0042470[melanosome] GO:0042698[ovulation cycle] GO:0043025[neuronal cell body] GO:0043203[axon hillock] GO:0046685[response to arsenic-containing substance] GO:0048471[perinuclear region of cytoplasm] GO:0050728[negative regulation of inflammatory response] GO:0050769[positive regulation of neurogenesis] GO:0060041[retina development in camera-type eye] GO:0060767[epithelial cell proliferation involved in prostate gland development] GO:0060770[negative regulation of epithelial cell proliferation involved in prostate gland development] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0071279[cellular response to cobalt ion] GO:0071300[cellular response to retinoic acid] GO:0071333[cellular response to glucose stimulus] GO:0071549[cellular response to dexamethasone stimulus] GO:1901215[negative regulation of neuron death] GO:1901652[response to peptide]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
