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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q32.32
Chromosome location (bp)
102777449 - 102911500
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types 1,2. In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome 3,4. Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'- linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance 5. Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001817[regulation of cytokine production] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0007165[signal transduction] GO:0008063[Toll signaling pathway] GO:0008270[zinc ion binding] GO:0031625[ubiquitin protein ligase binding] GO:0031996[thioesterase binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0045087[innate immune response] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0050688[regulation of defense response to virus]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Human disease related genes Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000151[ubiquitin ligase complex] GO:0001817[regulation of cytokine production] GO:0002224[toll-like receptor signaling pathway] GO:0002376[immune system process] GO:0004842[ubiquitin-protein transferase activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005768[endosome] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008063[Toll signaling pathway] GO:0008270[zinc ion binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030162[regulation of proteolysis] GO:0031625[ubiquitin protein ligase binding] GO:0031996[thioesterase binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032648[regulation of interferon-beta production] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0035631[CD40 receptor complex] GO:0035666[TRIF-dependent toll-like receptor signaling pathway] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0050688[regulation of defense response to virus] GO:0051607[defense response to virus] GO:0060337[type I interferon signaling pathway] GO:0070534[protein K63-linked ubiquitination] GO:1902554[serine/threonine protein kinase complex]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Human disease related genes Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0001817[regulation of cytokine production] GO:0002224[toll-like receptor signaling pathway] GO:0002376[immune system process] GO:0004842[ubiquitin-protein transferase activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005768[endosome] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008063[Toll signaling pathway] GO:0008270[zinc ion binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0016740[transferase activity] GO:0019903[protein phosphatase binding] GO:0030162[regulation of proteolysis] GO:0031625[ubiquitin protein ligase binding] GO:0031996[thioesterase binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032648[regulation of interferon-beta production] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0035631[CD40 receptor complex] GO:0035666[TRIF-dependent toll-like receptor signaling pathway] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0050688[regulation of defense response to virus] GO:0051607[defense response to virus] GO:0060337[type I interferon signaling pathway] GO:0070534[protein K63-linked ubiquitination] GO:1902554[serine/threonine protein kinase complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817[regulation of cytokine production] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0008063[Toll signaling pathway] GO:0008270[zinc ion binding] GO:0031625[ubiquitin protein ligase binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0045087[innate immune response] GO:0046872[metal ion binding] GO:0050688[regulation of defense response to virus]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Human disease related genes Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0001817[regulation of cytokine production] GO:0002224[toll-like receptor signaling pathway] GO:0002376[immune system process] GO:0004842[ubiquitin-protein transferase activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005768[endosome] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008063[Toll signaling pathway] GO:0008270[zinc ion binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0016740[transferase activity] GO:0019903[protein phosphatase binding] GO:0030162[regulation of proteolysis] GO:0031625[ubiquitin protein ligase binding] GO:0031996[thioesterase binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032648[regulation of interferon-beta production] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0035631[CD40 receptor complex] GO:0035666[TRIF-dependent toll-like receptor signaling pathway] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0046330[positive regulation of JNK cascade] GO:0046872[metal ion binding] GO:0048584[positive regulation of response to stimulus] GO:0050688[regulation of defense response to virus] GO:0051607[defense response to virus] GO:0060337[type I interferon signaling pathway] GO:0070534[protein K63-linked ubiquitination] GO:1902554[serine/threonine protein kinase complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817[regulation of cytokine production] GO:0005164[tumor necrosis factor receptor binding] GO:0005737[cytoplasm] GO:0008063[Toll signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0045087[innate immune response] GO:0046872[metal ion binding] GO:0050688[regulation of defense response to virus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817[regulation of cytokine production] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0007165[signal transduction] GO:0008063[Toll signaling pathway] GO:0008270[zinc ion binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0042981[regulation of apoptotic process] GO:0045087[innate immune response] GO:0050688[regulation of defense response to virus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817[regulation of cytokine production] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0007165[signal transduction] GO:0008063[Toll signaling pathway] GO:0008270[zinc ion binding] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0042981[regulation of apoptotic process] GO:0045087[innate immune response] GO:0050688[regulation of defense response to virus]
The Human Protein Atlas project is funded
