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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q12.2
Chromosome location (bp)
30240453 - 30246759
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine, Growth factor
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001974[blood vessel remodeling] GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005146[leukemia inhibitory factor receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005829[cytosol] GO:0006955[immune response] GO:0007260[tyrosine phosphorylation of STAT protein] GO:0007566[embryo implantation] GO:0008083[growth factor activity] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010646[regulation of cell communication] GO:0023051[regulation of signaling] GO:0030225[macrophage differentiation] GO:0030324[lung development] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033141[positive regulation of peptidyl-serine phosphorylation of STAT protein] GO:0033630[positive regulation of cell adhesion mediated by integrin] GO:0035019[somatic stem cell population maintenance] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0043410[positive regulation of MAPK cascade] GO:0045595[regulation of cell differentiation] GO:0045651[positive regulation of macrophage differentiation] GO:0045835[negative regulation of meiotic nuclear division] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046697[decidualization] GO:0046888[negative regulation of hormone secretion] GO:0048144[fibroblast proliferation] GO:0048146[positive regulation of fibroblast proliferation] GO:0048286[lung alveolus development] GO:0048644[muscle organ morphogenesis] GO:0048666[neuron development] GO:0048711[positive regulation of astrocyte differentiation] GO:0048861[leukemia inhibitory factor signaling pathway] GO:0048863[stem cell differentiation] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0060135[maternal process involved in female pregnancy] GO:0060426[lung vasculature development] GO:0060463[lung lobe morphogenesis] GO:0060707[trophoblast giant cell differentiation] GO:0060708[spongiotrophoblast differentiation] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0072108[positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0072307[regulation of metanephric nephron tubule epithelial cell differentiation] GO:0140013[meiotic nuclear division] GO:1900182[positive regulation of protein localization to nucleus] GO:1901676[positive regulation of histone H3-K27 acetylation] GO:1903025[regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005146[leukemia inhibitory factor receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005829[cytosol] GO:0006955[immune response] GO:0008083[growth factor activity] GO:0008284[positive regulation of cell population proliferation] GO:0010646[regulation of cell communication] GO:0023051[regulation of signaling] GO:0030225[macrophage differentiation] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033141[positive regulation of peptidyl-serine phosphorylation of STAT protein] GO:0033630[positive regulation of cell adhesion mediated by integrin] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0043410[positive regulation of MAPK cascade] GO:0045595[regulation of cell differentiation] GO:0045651[positive regulation of macrophage differentiation] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046888[negative regulation of hormone secretion] GO:0048861[leukemia inhibitory factor signaling pathway] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0072108[positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0072307[regulation of metanephric nephron tubule epithelial cell differentiation] GO:1900182[positive regulation of protein localization to nucleus] GO:1901676[positive regulation of histone H3-K27 acetylation]
The Human Protein Atlas project is funded
