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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q12.3
Chromosome location (bp)
31944522 - 31957603
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002028[regulation of sodium ion transport] GO:0003779[actin binding] GO:0004497[monooxygenase activity] GO:0005159[insulin-like growth factor receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006713[glucocorticoid catabolic process] GO:0006886[intracellular protein transport] GO:0007165[signal transduction] GO:0014704[intercalated disc] GO:0017080[sodium channel regulator activity] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0021762[substantia nigra development] GO:0035259[nuclear glucocorticoid receptor binding] GO:0042802[identical protein binding] GO:0042921[glucocorticoid receptor signaling pathway] GO:0044325[transmembrane transporter binding] GO:0045664[regulation of neuron differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0046982[protein heterodimerization activity] GO:0048167[regulation of synaptic plasticity] GO:0050774[negative regulation of dendrite morphogenesis] GO:0070062[extracellular exosome] GO:0086010[membrane depolarization during action potential] GO:0098793[presynapse] GO:0098978[glutamatergic synapse] GO:0099171[presynaptic modulation of chemical synaptic transmission] GO:0150048[cerebellar granule cell to Purkinje cell synapse] GO:2000649[regulation of sodium ion transmembrane transporter activity]
The Human Protein Atlas project is funded
