GENERAL INFORMATIONi
Gene namei GNAI1
Synonyms
Gene descriptioni G protein subunit alpha i1
Protein classi Cancer-related genes
Disease related genes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 7
Cytoband q21.11
Chromosome location (bp) 79768028 - 80226181
Number of transcriptsi 18
Ensembl ENSG00000127955 (version 109)
Entrez gene 2770
HGNC HGNC:4384
UniProt P63096 (UniProt - Evidence at protein level)
neXtProt NX_P63096
GeneCards GNAI1
Antibodypedia GNAI1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins 1, 2. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis 3. Required for cortical dynein-dynactin complex recruitment during metaphase 4. show less
Molecular function (UniProt)i Transducer
Biological process (UniProt)i Cell cycle, Cell division, Host-virus interaction, Mitosis, Transport
Ligand (UniProt)i GTP-binding, Magnesium, Metal-binding, Nucleotide-binding
Gene summary (Entrez)i Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
GNAI1-201
ENSP00000343027
ENST00000351004
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-203
ENSP00000391439
ENST00000442586
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-204
ENSP00000410572
ENST00000457358
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 302 aa
34.8 kDa 		No 0
GNAI1-206
ENSP00000497802
ENST00000647672
A0A3B3ITM0
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
Show all
 168 aa
19.7 kDa 		No 0
GNAI1-209
ENSP00000497717
ENST00000648098
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-210
ENSP00000497773
ENST00000648306
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-212
ENSP00000497051
ENST00000648412
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-214
ENSP00000497179
ENST00000648476
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-216
ENSP00000497379
ENST00000648663
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-217
ENSP00000497765
ENST00000648832
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-218
ENSP00000497760
ENST00000648877
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-219
ENSP00000496800
ENST00000648953
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-223
ENSP00000496829
ENST00000649225
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-224
ENSP00000497315
ENST00000649267
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-226
ENSP00000498091
ENST00000649487
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-227
ENSP00000498159
ENST00000649634
A0A3B3IUA8
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
Show all
 148 aa
16.7 kDa 		No 0
GNAI1-228
ENSP00000497260
ENST00000649796
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-229
ENSP00000497754
ENST00000649855
P63096
[Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001664 [G protein-coupled receptor binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G protein-coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G protein-coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0060236 [regulation of mitotic spindle organization]
GO:0070062 [extracellular exosome]
GO:0099738 [cell cortex region]
GO:1904322 [cellular response to forskolin]
GO:1904778 [positive regulation of protein localization to cell cortex]
Show all
 354 aa
40.4 kDa 		No 0

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The Human Protein Atlas

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