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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q35
Chromosome location (bp)
218419121 - 218453295
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Actin capping, Actin-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001726[ruffle] GO:0001951[intestinal D-glucose absorption] GO:0003779[actin binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005902[microvillus] GO:0005903[brush border] GO:0006915[apoptotic process] GO:0007010[cytoskeleton organization] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0008154[actin polymerization or depolymerization] GO:0008360[regulation of cell shape] GO:0009617[response to bacterium] GO:0010634[positive regulation of epithelial cell migration] GO:0015629[actin cytoskeleton] GO:0030027[lamellipodium] GO:0030041[actin filament polymerization] GO:0030042[actin filament depolymerization] GO:0030175[filopodium] GO:0030335[positive regulation of cell migration] GO:0030836[positive regulation of actin filament depolymerization] GO:0030855[epithelial cell differentiation] GO:0032233[positive regulation of actin filament bundle assembly] GO:0032432[actin filament bundle] GO:0032433[filopodium tip] GO:0032532[regulation of microvillus length] GO:0035727[lysophosphatidic acid binding] GO:0035729[cellular response to hepatocyte growth factor stimulus] GO:0040018[] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045010[actin nucleation] GO:0051014[actin filament severing] GO:0051015[actin filament binding] GO:0051016[barbed-end actin filament capping] GO:0051125[regulation of actin nucleation] GO:0051693[actin filament capping] GO:0060327[cytoplasmic actin-based contraction involved in cell motility] GO:0061041[regulation of wound healing] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0071364[cellular response to epidermal growth factor stimulus] GO:1902896[terminal web assembly] GO:1903078[positive regulation of protein localization to plasma membrane] GO:2000392[regulation of lamellipodium morphogenesis] GO:2000394[positive regulation of lamellipodium morphogenesis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001726[ruffle] GO:0003779[actin binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005902[microvillus] GO:0005903[brush border] GO:0006915[apoptotic process] GO:0007010[cytoskeleton organization] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0008154[actin polymerization or depolymerization] GO:0008360[regulation of cell shape] GO:0009617[response to bacterium] GO:0010634[positive regulation of epithelial cell migration] GO:0015629[actin cytoskeleton] GO:0030027[lamellipodium] GO:0030041[actin filament polymerization] GO:0030042[actin filament depolymerization] GO:0030175[filopodium] GO:0030335[positive regulation of cell migration] GO:0030836[positive regulation of actin filament depolymerization] GO:0030855[epithelial cell differentiation] GO:0032233[positive regulation of actin filament bundle assembly] GO:0032432[actin filament bundle] GO:0032433[filopodium tip] GO:0035727[lysophosphatidic acid binding] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042995[cell projection] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045010[actin nucleation] GO:0051014[actin filament severing] GO:0051015[actin filament binding] GO:0051016[barbed-end actin filament capping] GO:0051125[regulation of actin nucleation] GO:0051693[actin filament capping] GO:0060327[cytoplasmic actin-based contraction involved in cell motility] GO:0061041[regulation of wound healing] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0071364[cellular response to epidermal growth factor stimulus] GO:2000392[regulation of lamellipodium morphogenesis] GO:2000394[positive regulation of lamellipodium morphogenesis]