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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q34.3
Chromosome location (bp)
136881912 - 136926607
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis 1. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lipid-binding, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000151[ubiquitin ligase complex] GO:0002637[regulation of immunoglobulin production] GO:0002726[positive regulation of T cell cytokine production] GO:0002947[tumor necrosis factor receptor superfamily complex] GO:0004842[ubiquitin-protein transferase activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005174[CD40 receptor binding] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0007250[activation of NF-kappaB-inducing kinase activity] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0012506[vesicle membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0023019[signal transduction involved in regulation of gene expression] GO:0030163[protein catabolic process] GO:0030674[protein-macromolecule adaptor activity] GO:0031435[mitogen-activated protein kinase kinase kinase binding] GO:0031625[ubiquitin protein ligase binding] GO:0031996[thioesterase binding] GO:0032743[positive regulation of interleukin-2 production] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034351[negative regulation of glial cell apoptotic process] GO:0034976[response to endoplasmic reticulum stress] GO:0035631[CD40 receptor complex] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043120[tumor necrosis factor binding] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043254[regulation of protein-containing complex assembly] GO:0043507[positive regulation of JUN kinase activity] GO:0044877[protein-containing complex binding] GO:0045121[membrane raft] GO:0046328[regulation of JNK cascade] GO:0046330[positive regulation of JNK cascade] GO:0046625[sphingolipid binding] GO:0046872[metal ion binding] GO:0048255[mRNA stabilization] GO:0048584[positive regulation of response to stimulus] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051865[protein autoubiquitination] GO:0065003[protein-containing complex assembly] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070534[protein K63-linked ubiquitination] GO:0071732[cellular response to nitric oxide] GO:0097057[TRAF2-GSTP1 complex] GO:0097300[programmed necrotic cell death] GO:0097400[interleukin-17-mediated signaling pathway] GO:1901215[negative regulation of neuron death] GO:1903265[positive regulation of tumor necrosis factor-mediated signaling pathway] GO:1903721[positive regulation of I-kappaB phosphorylation] GO:1990604[IRE1-TRAF2-ASK1 complex] GO:2001238[positive regulation of extrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
