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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q23.3
Chromosome location (bp)
64503712 - 64533690
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a transcriptional repressor 1. Represses cAMP-responsive element (CRE)-mediated transcriptional activation 2. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis 3. Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation, DNA damage, DNA repair, Immunity, Innate immunity, Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables K63-linked polyubiquitin modification-dependent protein binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including cellular response to UV; nucleobase-containing compound biosynthetic process; and protein homooligomerization. Located in centrosome; nuclear body; and nuclear membrane. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9Y2K1 [Direct mapping] Zinc finger and BTB domain-containing protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0002711[positive regulation of T cell mediated immunity] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005813[centrosome] GO:0006281[DNA repair] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0016604[nuclear body] GO:0019985[translesion synthesis] GO:0030154[cell differentiation] GO:0031965[nuclear membrane] GO:0032825[positive regulation of natural killer cell differentiation] GO:0034644[cellular response to UV] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042803[protein homodimerization activity] GO:0045087[innate immune response] GO:0045582[positive regulation of T cell differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0048538[thymus development] GO:0051260[protein homooligomerization] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding] GO:2000176[positive regulation of pro-T cell differentiation]
Q9Y2K1 [Direct mapping] Zinc finger and BTB domain-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0002711[positive regulation of T cell mediated immunity] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005813[centrosome] GO:0006281[DNA repair] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0016604[nuclear body] GO:0019985[translesion synthesis] GO:0030154[cell differentiation] GO:0031965[nuclear membrane] GO:0032825[positive regulation of natural killer cell differentiation] GO:0034644[cellular response to UV] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042803[protein homodimerization activity] GO:0045087[innate immune response] GO:0045582[positive regulation of T cell differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0048538[thymus development] GO:0051260[protein homooligomerization] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding] GO:2000176[positive regulation of pro-T cell differentiation]
Q9Y2K1 [Direct mapping] Zinc finger and BTB domain-containing protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0002376[immune system process] GO:0002711[positive regulation of T cell mediated immunity] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005813[centrosome] GO:0006281[DNA repair] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0016604[nuclear body] GO:0019985[translesion synthesis] GO:0030154[cell differentiation] GO:0030183[B cell differentiation] GO:0031965[nuclear membrane] GO:0032825[positive regulation of natural killer cell differentiation] GO:0033077[T cell differentiation in thymus] GO:0034644[cellular response to UV] GO:0042789[mRNA transcription by RNA polymerase II] GO:0042803[protein homodimerization activity] GO:0045087[innate immune response] GO:0045582[positive regulation of T cell differentiation] GO:0046872[metal ion binding] GO:0046982[protein heterodimerization activity] GO:0048538[thymus development] GO:0051260[protein homooligomerization] GO:0070530[K63-linked polyubiquitin modification-dependent protein binding] GO:2000176[positive regulation of pro-T cell differentiation]
The Human Protein Atlas project is funded
