Expression of CD70 in glioma - The Human Protein Atlas

GLIOBLASTOMA MULTIFORME (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

CD70 is not prognostic in Glioblastoma Multiforme (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 0.53

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

3-year survival highⁱ N/A

3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average TPM

3.3

Number of samples

141

Samples

Sample	Description	TPM
TCGA-02-0055-01A	0 years, female, white, stage:'--, dead, 76 days	85.7
TCGA-06-0130-01A	0 years, male, white, stage:'--, dead, 394 days	46.5
TCGA-06-0644-01A	0 years, male, black or african american, stage:'--, dead, 384 days	42.8
TCGA-06-0190-01A	0 years, male, white, stage:'--, dead, 317 days	32.5
TCGA-27-1832-01A	0 years, female, white, stage:'--, dead, 300 days	22.9
TCGA-41-4097-01A	0 years, female, white, stage:'--, dead, 6 days	22.2
TCGA-27-2524-01A	0 years, male, white, stage:'--, dead, 231 days	21.1
TCGA-28-2509-01A	0 years, female, white, stage:'--, alive, 145 days	10.7
TCGA-32-2615-01A	0 years, male, white, stage:'--, dead, 485 days	9.9
TCGA-26-5134-01A	0 years, male, white, stage:'--, alive, 167 days	9.2
TCGA-02-2486-01A	0 years, male, white, stage:'--, dead, 618 days	8.8
TCGA-06-2565-01A	0 years, male, asian, stage:'--, dead, 506 days	7.3
TCGA-06-0141-01A	0 years, male, white, stage:'--, dead, 313 days	7.1
TCGA-12-0616-01A	0 years, female, white, stage:'--, dead, 448 days	5.6
TCGA-28-2513-01A	0 years, female, white, stage:'--, alive, 222 days	5.4
TCGA-28-5215-01A	0 years, female, white, stage:'--, dead, 335 days	4.9
TCGA-06-0645-01A	0 years, female, white, stage:'--, dead, 175 days	4.6
TCGA-32-2634-01A	0 years, male, white, stage:'--, alive, 693 days	4.1
TCGA-19-1390-01A	0 years, female, white, stage:'--, dead, 772 days	4.0
TCGA-28-1753-01A	0 years, male, white, stage:'--, alive, 37 days	3.4
TCGA-06-0211-01A	0 years, male, white, stage:'--, dead, 360 days	3.4
TCGA-28-5208-01A	0 years, male, white, stage:'--, dead, 544 days	3.2
TCGA-06-0156-01A	0 years, male, white, stage:'--, dead, 178 days	3.2
TCGA-19-2620-01A	0 years, male, white, stage:'--, dead, 148 days	3.1
TCGA-06-0139-01A	0 years, male, white, stage:'--, dead, 362 days	3.0
TCGA-12-0619-01A	0 years, male, white, stage:'--, dead, 1062 days	3.0
TCGA-06-0882-01A	0 years, male, white, stage:'--, dead, 632 days	2.7
TCGA-06-5414-01A	0 years, male, white, stage:'--, alive, 273 days	2.6
TCGA-26-5133-01A	0 years, male, white, stage:'--, alive, 452 days	2.4
TCGA-19-4065-01A	0 years, male, white, stage:'--, alive, 214 days	2.4
TCGA-02-2483-01A	0 years, male, asian, stage:'--, alive, 466 days	2.3
TCGA-06-5410-01A	0 years, female, white, stage:'--, dead, 108 days	2.3
TCGA-06-5416-01A	0 years, female, white, stage:'--, alive, 204 days	2.2
TCGA-14-0789-01A	0 years, male, white, stage:'--, dead, 342 days	2.1
TCGA-14-2554-01A	0 years, female, white, stage:'--, dead, 532 days	2.1
TCGA-06-0743-01A	0 years, male, white, stage:'--, dead, 803 days	2.0
TCGA-06-0878-01A	0 years, male, white, stage:'--, alive, 218 days	1.9
TCGA-32-2632-01A	0 years, male, white, stage:'--, dead, 269 days	1.9
TCGA-14-1034-01A	0 years, female, stage:'--, dead, 485 days	1.8
TCGA-06-5408-01A	0 years, female, white, stage:'--, dead, 357 days	1.7
TCGA-14-1829-01A	0 years, male, black or african american, stage:'--, alive, 218 days	1.7
TCGA-06-0210-01A	0 years, female, white, stage:'--, dead, 225 days	1.7
TCGA-27-2519-01A	0 years, male, white, stage:'--, dead, 550 days	1.6
TCGA-06-2567-01A	0 years, male, white, stage:'--, dead, 133 days	1.6
TCGA-06-0219-01A	0 years, male, white, stage:'--, dead, 22 days	1.6
TCGA-28-5218-01A	0 years, male, white, stage:'--, dead, 157 days	1.5
TCGA-06-0168-01A	0 years, female, white, stage:'--, dead, 598 days	1.5
TCGA-19-2619-01A	0 years, female, black or african american, stage:'--, alive, 294 days	1.4
TCGA-06-5418-01A	0 years, female, white, stage:'--, dead, 83 days	1.4
TCGA-28-5204-01A	0 years, male, white, stage:'--, dead, 454 days	1.4
TCGA-06-5411-01A	0 years, male, white, stage:'--, dead, 254 days	1.4
TCGA-06-0184-01A	0 years, male, white, stage:'--, dead, 2126 days	1.3
TCGA-27-1830-01A	0 years, male, white, stage:'--, dead, 154 days	1.1
TCGA-12-3652-01A	0 years, male, white, stage:'--, dead, 1062 days	1.1
TCGA-06-0132-01A	0 years, male, white, stage:'--, dead, 771 days	1.0
TCGA-28-5207-01A	0 years, male, white, stage:'--, dead, 343 days	1.0
TCGA-06-0238-01A	0 years, male, white, stage:'--, dead, 405 days	1.0
TCGA-26-5139-01A	0 years, female, white, stage:'--, alive, 48 days	1.0
TCGA-06-0745-01A	0 years, male, white, stage:'--, dead, 239 days	1.0
TCGA-14-1825-01A	0 years, male, white, stage:'--, dead, 232 days	0.9
TCGA-14-0787-01A	0 years, male, asian, stage:'--, dead, 68 days	0.9
TCGA-06-0686-01A	0 years, male, white, stage:'--, dead, 432 days	0.9
TCGA-06-0749-01A	0 years, male, black or african american, stage:'--, dead, 82 days	0.8
TCGA-06-0646-01A	0 years, male, white, stage:'--, dead, 175 days	0.8
TCGA-06-0158-01A	0 years, male, white, stage:'--, dead, 329 days	0.8
TCGA-41-3915-01A	0 years, male, white, stage:'--, dead, 360 days	0.8
TCGA-76-4929-01A	0 years, female, white, stage:'--, dead, 111 days	0.8
TCGA-06-2562-01A	0 years, male, white, stage:'--, dead, 382 days	0.8
TCGA-27-2526-01A	0 years, female, white, stage:'--, dead, 87 days	0.8
TCGA-06-2557-01A	0 years, male, black or african american, stage:'--, dead, 33 days	0.8
TCGA-06-5413-01A	0 years, male, white, stage:'--, alive, 268 days	0.8
TCGA-06-2561-01A	0 years, female, white, stage:'--, dead, 537 days	0.7
TCGA-32-1970-01A	0 years, male, white, stage:'--, dead, 468 days	0.7
TCGA-32-4213-01A	0 years, female, white, stage:'--, alive, 604 days	0.7
TCGA-06-5412-01A	0 years, female, white, stage:'--, dead, 138 days	0.7
TCGA-27-1837-01A	0 years, male, white, stage:'--, dead, 427 days	0.7
TCGA-32-1982-01A	0 years, female, white, stage:'--, dead, 142 days	0.7
TCGA-14-1823-01A	0 years, female, white, stage:'--, dead, 543 days	0.7
TCGA-27-1831-01A	0 years, male, white, stage:'--, dead, 505 days	0.6
TCGA-14-0817-01A	0 years, female, white, stage:'--, dead, 164 days	0.6
TCGA-02-0047-01A	0 years, male, white, stage:'--, dead, 448 days	0.6
TCGA-32-1980-01A	0 years, male, white, stage:'--, dead, 36 days	0.6
TCGA-06-0187-01A	0 years, male, white, stage:'--, dead, 828 days	0.6
TCGA-12-3650-01A	0 years, male, white, stage:'--, dead, 333 days	0.6
TCGA-06-0174-01A	0 years, male, white, stage:'--, dead, 98 days	0.6
TCGA-12-5295-01A	0 years, female, white, stage:'--, dead, 454 days	0.6
TCGA-76-4927-01A	0 years, male, white, stage:'--, dead, 535 days	0.5
TCGA-32-5222-01A	0 years, male, white, stage:'--, dead, 585 days	0.5
TCGA-06-0138-01A	0 years, male, white, stage:'--, dead, 737 days	0.5
TCGA-28-2514-01A	0 years, male, asian, stage:'--, alive, 160 days	0.5
TCGA-76-4931-01A	0 years, female, white, stage:'--, dead, 279 days	0.5
TCGA-06-2564-01A	0 years, male, white, stage:'--, alive, 181 days	0.4
TCGA-02-2485-01A	0 years, male, black or african american, stage:'--, alive, 470 days	0.4
TCGA-06-5856-01A	0 years, male, white, stage:'--, dead, 114 days	0.4
TCGA-06-0125-01A	0 years, female, white, stage:'--, dead, 1448 days	0.4
TCGA-32-2638-01A	0 years, male, white, stage:'--, dead, 766 days	0.4
TCGA-26-5135-01A	0 years, female, white, stage:'--, dead, 270 days	0.4
TCGA-27-1834-01A	0 years, male, white, stage:'--, dead, 1233 days	0.4
TCGA-28-5216-01A	0 years, male, white, stage:'--, alive, 415 days	0.4
TCGA-14-0871-01A	0 years, female, white, stage:'--, dead, 880 days	0.4
TCGA-41-5651-01A	0 years, female, black or african american, stage:'--, dead, 460 days	0.4
TCGA-41-2571-01A	0 years, male, white, stage:'--, dead, 26 days	0.4
TCGA-06-2559-01A	0 years, male, white, stage:'--, dead, 150 days	0.4
TCGA-06-0178-01A	0 years, male, white, stage:'--, dead, 2681 days	0.3
TCGA-06-2563-01A	0 years, female, white, stage:'--, alive, 932 days	0.3
TCGA-27-2523-01A	0 years, male, white, stage:'--, dead, 489 days	0.3
TCGA-06-0744-01A	0 years, male, white, stage:'--, dead, 1426 days	0.3
TCGA-06-1804-01A	0 years, female, white, stage:'--, dead, 414 days	0.3
TCGA-41-2572-01A	0 years, male, white, stage:'--, dead, 406 days	0.3
TCGA-06-0157-01A	0 years, female, white, stage:'--, dead, 97 days	0.3
TCGA-32-2616-01A	0 years, female, white, stage:'--, dead, 224 days	0.3
TCGA-06-0750-01A	0 years, male, white, stage:'--, dead, 28 days	0.3
TCGA-76-4932-01A	0 years, female, white, stage:'--, dead, 1458 days	0.3
TCGA-06-5859-01A	0 years, male, white, stage:'--, alive, 139 days	0.3
TCGA-15-0742-01A	0 years, male, white, stage:'--, dead, 419 days	0.3
TCGA-26-1442-01A	0 years, male, white, stage:'--, alive, 953 days	0.3
TCGA-06-0129-01A	0 years, male, asian, stage:'--, dead, 1024 days	0.3
TCGA-12-5299-01A	0 years, female, white, stage:'--, dead, 98 days	0.2
TCGA-08-0386-01A	0 years, male, white, stage:'--, dead, 548 days	0.2
TCGA-06-0747-01A	0 years, male, white, stage:'--, dead, 82 days	0.2
TCGA-19-2624-01A	0 years, male, white, stage:'--, dead, 5 days	0.2
TCGA-06-2570-01A	0 years, female, white, stage:'--, alive, 958 days	0.2
TCGA-15-1444-01A	0 years, male, white, stage:'--, dead, 1537 days	0.2
TCGA-27-2521-01A	0 years, male, white, stage:'--, dead, 510 days	0.2
TCGA-19-2629-01A	0 years, male, white, stage:'--, dead, 737 days	0.2
TCGA-27-2528-01A	0 years, male, white, stage:'--, dead, 480 days	0.2
TCGA-12-3653-01A	0 years, female, white, stage:'--, dead, 442 days	0.2
TCGA-12-0821-01A	0 years, male, white, stage:'--, dead, 323 days	0.2
TCGA-16-0846-01A	0 years, male, white, stage:'--, dead, 119 days	0.2
TCGA-76-4925-01A	0 years, male, white, stage:'--, dead, 146 days	0.2
TCGA-19-5960-01A	0 years, male, white, stage:'--, dead, 455 days	0.1
TCGA-28-5209-01A	0 years, female, white, stage:'--, alive, 442 days	0.1
TCGA-06-5858-01A	0 years, female, white, stage:'--, alive, 187 days	0.1
TCGA-06-2569-01A	0 years, female, black or african american, stage:'--, alive, 13 days	0.1
TCGA-19-2625-01A	0 years, female, white, stage:'--, dead, 124 days	0.1
TCGA-28-5220-01A	0 years, male, white, stage:'--, dead, 388 days	0.1
TCGA-26-5132-01A	0 years, male, white, stage:'--, alive, 286 days	0.1
TCGA-27-1835-01A	0 years, female, white, stage:'--, dead, 648 days	0.1
TCGA-06-2558-01A	0 years, female, white, stage:'--, dead, 380 days	0.1
TCGA-12-0618-01A	0 years, male, white, stage:'--, dead, 395 days	0.0
TCGA-06-5417-01A	0 years, female, white, stage:'--, alive, 155 days	0.0
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GLIOBLASTOMA MULTIFORME (VALIDATION) - Interactive survival scatter plotⁱ

& Survival analysisⁱ

Survival analysis data not available.

TCGA RNA samplesⁱ

Average TPM

0.3

Number of samples

Samples

Sample	Description	TPM
AK185	N, NA, stage:NA, alive, 330 days	9.4
AK236	N, NA, stage:NA, dead, 360 days	3.9
AK195	N, NA, stage:NA, dead, 390 days	1.7
AK100	N, NA, stage:NA, alive, 960 days	1.2
AK066	N, NA, stage:NA, alive, 960 days	0.8
AK183	N, NA, stage:NA, alive, 360 days	0.6
AK055	N, NA, stage:NA, dead, 240 days	0.5
AK139	N, NA, stage:NA, dead, 270 days	0.5
AK030	N, NA, stage:NA, dead, 120 days	0.4
AK072	N, NA, stage:NA, dead, 150 days	0.4
AK218	N, NA, stage:NA, dead, 180 days	0.3
AK205	N, NA, stage:NA, dead, 120 days	0.3
AK005	N, NA, stage:NA, dead, 240 days	0.2
AK051	N, NA, stage:NA, dead, 360 days	0.2
AK227	N, NA, stage:NA, alive, 300 days	0.2
AK188	N, NA, stage:NA, alive, 420 days	0.2
AK173	N, NA, stage:NA, dead, 180 days	0.2
AK153	N, NA, stage:NA, dead, 240 days	0.1
AK216	N, NA, stage:NA, dead, 360 days	0.1
AK167	N, NA, stage:NA, dead, 180 days	0.1
AK002	N, NA, stage:NA, dead, 570 days	0.1
AK076	N, NA, stage:NA, alive, 660 days	0.1
AK071	N, NA, stage:NA, dead, 540 days	0.1
AK142	N, NA, stage:NA, alive, 90 days	0.1
AK041	N, NA, stage:NA, alive, 810 days	0.1
AK079	N, NA, stage:NA, dead, 210 days	0.1
AK088	N, NA, stage:NA, dead, 360 days	0.0
AK085	N, NA, stage:NA, alive, 660 days	0.0
AK133	N, NA, stage:NA, dead, 360 days	0.0
AK103	N, NA, stage:NA, alive, 1320 days	0.0
AK091	N, NA, stage:NA, dead, 210 days	0.0
AK068	N, NA, stage:NA, alive, 360 days	0.0
AK053	N, NA, stage:NA, dead, 300 days	0.0
AK149	N, NA, stage:NA, dead, 420 days	0.0
AK099	N, NA, stage:NA, dead, 420 days	0.0
AK003	N, NA, stage:NA, dead, 600 days	0.0
AK231	N, NA, stage:NA, dead, 240 days	0.0
AK124	N, NA, stage:NA, alive, 1920 days	0.0
AK015	N, NA, stage:NA, alive, 720 days	0.0
AK081	N, NA, stage:NA, dead, 180 days	0.0
AK199	N, NA, stage:NA, alive, 1860 days	0.0
AK089	N, NA, stage:NA, dead, 330 days	0.0
AK165	N, NA, stage:NA, alive, 360 days	0.0
AK226	N, NA, stage:NA, dead, 360 days	0.0
AK098	N, NA, stage:NA, dead, 660 days	0.0
AK158	N, NA, stage:NA, dead, 360 days	0.0
AK117	N, NA, stage:NA, dead, 210 days	0.0
AK123	N, NA, stage:NA, dead, 180 days	0.0
AK006	N, NA, stage:NA, dead, 360 days	0.0
AK134	N, NA, stage:NA, dead, 360 days	0.0
AK156	N, NA, stage:NA, dead, 330 days	0.0
AK049	N, NA, stage:NA, dead, 180 days	0.0
AK074	N, NA, stage:NA, alive, 300 days	0.0
AK035	N, NA, stage:NA, dead, 210 days	0.0
AK043	N, NA, stage:NA, alive, 660 days	0.0
AK178	N, NA, stage:NA, dead, 240 days	0.0
AK102	N, NA, stage:NA, alive, 1740 days	0.0
AK213	N, NA, stage:NA, alive, 2010 days	0.0
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GLIOBLASTOMA MULTIFORME - Protein relative expression (CPTAC)

Number of samples

110

Samples

Sample ID	Sample type	nRPX
CPT0206330003	Tumor	N/A
CPT0186100003	Tumor	N/A
CPT0123530003	Tumor	N/A
CPT0201710003	Tumor	N/A
CPT0216920008	Tumor	N/A
CPT0218890004	Tumor	N/A
CPT0224390004	Tumor	N/A
CPT0204390003	Normal	N/A
CPT0093590003	Tumor	N/A
CPT0167750004	Tumor	N/A
CPT0204400003	Normal	N/A
CPT0079790003	Tumor	N/A
CPT0218690004	Tumor	N/A
CPT0204370003	Normal	N/A
CPT0161730003	Tumor	N/A
CPT0168720003	Tumor	N/A
CPT0206880003	Tumor	N/A
CPT0189650004	Tumor	N/A
CPT0204350003	Normal	N/A
CPT0168380003	Tumor	N/A
CPT0205890003	Tumor	N/A
CPT0217880003	Tumor	N/A
CPT0206560003	Tumor	N/A
CPT0087680003	Tumor	N/A
CPT0206000004	Tumor	N/A
CPT0218670003	Tumor	N/A
CPT0204340003	Normal	N/A
CPT0189850004	Tumor	N/A
CPT0224330003	Tumor	N/A
CPT0218330004	Tumor	N/A
CPT0167640003	Tumor	N/A
CPT0002410011	Tumor	N/A
CPT0093450003	Tumor	N/A
CPT0206110003	Tumor	N/A
CPT0217430008	Tumor	N/A
CPT0217000004	Tumor	N/A
CPT0196850003	Tumor	N/A
CPT0189250003	Tumor	N/A
CPT0189570004	Tumor	N/A
CPT0162020003	Tumor	N/A
CPT0167530003	Tumor	N/A
CPT0207030003	Tumor	N/A
CPT0127420003	Tumor	N/A
CPT0205670004	Tumor	N/A
CPT0208980003	Tumor	N/A
CPT0206780003	Tumor	N/A
CPT0182500003	Tumor	N/A
CPT0217710008	Tumor	N/A
CPT0168830003	Tumor	N/A
CPT0182550003	Tumor	N/A
CPT0189460003	Tumor	N/A
CPT0167860004	Tumor	N/A
CPT0125220003	Tumor	N/A
CPT0171580008	Tumor	N/A
CPT0087730003	Tumor	N/A
CPT0104330003	Tumor	N/A
CPT0168590003	Tumor	N/A
CPT0205450004	Tumor	N/A
CPT0219080004	Tumor	N/A
CPT0087570003	Tumor	N/A
CPT0162140003	Tumor	N/A
CPT0175060003	Tumor	N/A
CPT0205780003	Tumor	N/A
CPT0218960004	Tumor	N/A
CPT0064650003	Tumor	N/A
CPT0125570003	Tumor	N/A
CPT0190360004	Tumor	N/A
CPT0206670004	Tumor	N/A
CPT0204380003	Normal	N/A
CPT0092440003	Tumor	N/A
CPT0162100003	Tumor	N/A
CPT0221180003	Tumor	N/A
CPT0225760003	Tumor	N/A
CPT0093510003	Tumor	N/A
CPT0190240004	Tumor	N/A
CPT0228220003	Tumor	N/A
CPT0204410003	Normal	N/A
CPT0224540004	Tumor	N/A
CPT0209440003	Tumor	N/A
CPT0089150003	Tumor	N/A
CPT0204360003	Normal	N/A
CPT0168080003	Tumor	N/A
CPT0078580003	Tumor	N/A
CPT0127480003	Tumor	N/A
CPT0204420003	Normal	N/A
CPT0218830004	Tumor	N/A
CPT0225730003	Tumor	N/A
CPT0093360003	Tumor	N/A
CPT0168270003	Tumor	N/A
CPT0206450003	Tumor	N/A
CPT0207090003	Tumor	N/A
CPT0104220003	Tumor	N/A
CPT0224600003	Tumor	N/A
CPT0087950003	Tumor	N/A
CPT0204330003	Normal	N/A
CPT0199770003	Tumor	N/A
CPT0205570003	Tumor	N/A
CPT0093550003	Tumor	N/A
CPT0167970003	Tumor	N/A
CPT0182580003	Tumor	N/A
CPT0168480003	Tumor	N/A
CPT0206230003	Tumor	N/A
CPT0189750004	Tumor	N/A
CPT0217100003	Tumor	N/A
CPT0064890003	Tumor	N/A
CPT0217190003	Tumor	N/A
CPT0218770003	Tumor	N/A
CPT0125510003	Tumor	N/A
CPT0217060003	Tumor	N/A
CPT0071100003	Tumor	N/A
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GLIOMA - Protein expressionⁱ

Pending cancer tissue analysis