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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Metabolic proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.32
Chromosome location (bp)
58389229 - 58451101
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 1,2. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner 3. Via interaction with WDR44 participates in neosynthesized protein export 4. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity 5,6. Involved in cellular calcium homeostasis regulation 7....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Unfolded protein response
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O95292 [Direct mapping] Vesicle-associated membrane protein-associated protein B/C
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Metabolic proteins Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006874[cellular calcium ion homeostasis] GO:0006888[endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0006986[response to unfolded protein] GO:0007029[endoplasmic reticulum organization] GO:0008017[microtubule binding] GO:0016020[membrane] GO:0019899[enzyme binding] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0033149[FFAT motif binding] GO:0036498[IRE1-mediated unfolded protein response] GO:0042803[protein homodimerization activity] GO:0044790[suppression of viral release by host] GO:0044828[negative regulation by host of viral genome replication] GO:0044830[modulation by host of viral RNA genome replication] GO:0045070[positive regulation of viral genome replication] GO:0045296[cadherin binding] GO:0046725[negative regulation by virus of viral protein levels in host cell] GO:0046982[protein heterodimerization activity] GO:0048487[beta-tubulin binding] GO:0061817[endoplasmic reticulum-plasma membrane tethering] GO:0090114[COPII-coated vesicle budding] GO:0090158[endoplasmic reticulum membrane organization]
O95292 [Direct mapping] Vesicle-associated membrane protein-associated protein B/C
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Q53XM7 [Target identity:100%; Query identity:100%] VAMP (Vesicle-associated membrane protein)-associated protein B and C; VAMP (Vesicle-associated membrane protein)-associated protein B and C, isoform CRA_b; cDNA FLJ13179 fis, clone NT2RP3003918, highly similar to Vesicle-associated membrane protein-associated protein B/C
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Metabolic proteins Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0006874[cellular calcium ion homeostasis] GO:0006888[endoplasmic reticulum to Golgi vesicle-mediated transport] GO:0006986[response to unfolded protein] GO:0007029[endoplasmic reticulum organization] GO:0008017[microtubule binding] GO:0016020[membrane] GO:0019076[viral release from host cell] GO:0019899[enzyme binding] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0033149[FFAT motif binding] GO:0036498[IRE1-mediated unfolded protein response] GO:0042803[protein homodimerization activity] GO:0044829[positive regulation by host of viral genome replication] GO:0045070[positive regulation of viral genome replication] GO:0045296[cadherin binding] GO:0046982[protein heterodimerization activity] GO:0048487[beta-tubulin binding] GO:0061817[endoplasmic reticulum-plasma membrane tethering] GO:0090114[COPII-coated vesicle budding] GO:0090158[endoplasmic reticulum membrane organization]
The Human Protein Atlas project is funded
