GENERAL INFORMATIONi
Gene namei PTK2B
Synonyms CADTK, CAKB, FAK2, PTK, PYK2, RAFTK
Gene descriptioni Protein tyrosine kinase 2 beta
Protein classi Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 8
Cytoband p21.2
Chromosome location (bp) 27311482 - 27459391
Number of transcriptsi 9
Ensembl ENSG00000120899 (version 109)
Entrez gene 2185
HGNC HGNC:9612
UniProt Q14289 (UniProt - Evidence at protein level)
neXtProt NX_Q14289
GeneCards PTK2B
Antibodypedia PTK2B antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. show less
Molecular function (UniProt)i Kinase, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i Adaptive immunity, Angiogenesis, Immunity
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PTK2B-201
ENSP00000332816
ENST00000346049
Q14289
[Direct mapping] Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000302 [response to reactive oxygen species]
GO:0001525 [angiogenesis]
GO:0001556 [oocyte maturation]
GO:0001666 [response to hypoxia]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0002931 [response to ischemia]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006968 [cellular defense response]
GO:0006970 [response to osmotic stress]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009410 [response to xenobiotic stimulus]
GO:0009612 [response to mechanical stimulus]
GO:0009725 [response to hormone]
GO:0009749 [response to glucose]
GO:0010226 [response to lithium ion]
GO:0010243 [response to organonitrogen compound]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010656 [negative regulation of muscle cell apoptotic process]
GO:0010752 [regulation of cGMP-mediated signaling]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014009 [glial cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030279 [negative regulation of ossification]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035902 [response to immobilization stress]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell population proliferation]
GO:0042220 [response to cocaine]
GO:0042542 [response to hydrogen peroxide]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043149 [stress fiber assembly]
GO:0043157 [response to cation stress]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043423 [3-phosphoinositide-dependent protein kinase binding]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043534 [blood vessel endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0043621 [protein self-association]
GO:0044297 [cell body]
GO:0044877 [protein-containing complex binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045428 [regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045453 [bone resorption]
GO:0045471 [response to ethanol]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045727 [positive regulation of translation]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051591 [response to cAMP]
GO:0051592 [response to calcium ion]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0060292 [long-term synaptic depression]
GO:0065003 [protein-containing complex assembly]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0071310 [cellular response to organic substance]
GO:0071498 [cellular response to fluid shear stress]
GO:0086100 [endothelin receptor signaling pathway]
GO:0090630 [activation of GTPase activity]
GO:0097440 [apical dendrite]
GO:0098685 [Schaffer collateral - CA1 synapse]
GO:0098793 [presynapse]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:0099092 [postsynaptic density, intracellular component]
GO:0099151 [regulation of postsynaptic density assembly]
GO:0099170 [postsynaptic modulation of chemical synaptic transmission]
GO:2000058 [regulation of ubiquitin-dependent protein catabolic process]
GO:2000060 [positive regulation of ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
 1009 aa
115.9 kDa 		No 0
PTK2B-203
ENSP00000380638
ENST00000397501
Q14289
[Direct mapping] Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell population proliferation]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0043621 [protein self-association]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0065003 [protein-containing complex assembly]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0071310 [cellular response to organic substance]
GO:0086100 [endothelin receptor signaling pathway]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
 1009 aa
115.9 kDa 		No 0
PTK2B-204
ENSP00000416174
ENST00000412793
C9JHV9
[Direct mapping] Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005856 [cytoskeleton]
GO:0007165 [signal transduction]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell population proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 213 aa
24.9 kDa 		No 0
PTK2B-205
ENSP00000391995
ENST00000420218
Q14289
[Direct mapping] Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell population proliferation]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0043621 [protein self-association]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0065003 [protein-containing complex assembly]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0071310 [cellular response to organic substance]
GO:0086100 [endothelin receptor signaling pathway]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
 967 aa
111.2 kDa 		No 0
PTK2B-210
ENSP00000427931
ENST00000517339
Q14289
[Direct mapping] Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell population proliferation]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0043621 [protein self-association]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051128 [regulation of cellular component organization]
GO:0051239 [regulation of multicellular organismal process]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0065003 [protein-containing complex assembly]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0071310 [cellular response to organic substance]
GO:0086100 [endothelin receptor signaling pathway]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
 967 aa
111.2 kDa 		No 0
PTK2B-211
ENSP00000428837
ENST00000519512
H0YB74
[Direct mapping] Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005856 [cytoskeleton]
GO:0007165 [signal transduction]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell population proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 194 aa
21.7 kDa 		No 0
PTK2B-214
ENSP00000430404
ENST00000521164
E5RK84
[Direct mapping] Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0007165 [signal transduction]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell population proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 103 aa
11.6 kDa 		No 0
PTK2B-216
ENSP00000429694
ENST00000522338
E5RHL2
[Direct mapping] Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0007165 [signal transduction]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell population proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 68 aa
7.6 kDa 		No 0
PTK2B-217
ENSP00000428271
ENST00000522517
E5RJ77
[Direct mapping] Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005856 [cytoskeleton]
GO:0007165 [signal transduction]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell population proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 184 aa
21.5 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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