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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Potassium voltage-gated channel interacting protein 2
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q24.32
Chromosome location (bp)
101825974 - 101843920
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels 1,2,3,4,5,6. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner 7,8,9,10,11,12. Involved in KCND2 and KCND3 trafficking to the cell surface 13. May be required for the expression of I(To) currents in the heart (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Ion channel, Potassium channel, Voltage-gated channel
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ion transport, Potassium transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding, Potassium
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9NS61 [Direct mapping] Kv channel-interacting protein 2
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Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0005244[voltage-gated ion channel activity] GO:0005250[A-type (transient outward) potassium channel activity] GO:0005267[potassium channel activity] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006936[muscle contraction] GO:0007165[signal transduction] GO:0007268[chemical synaptic transmission] GO:0008016[regulation of heart contraction] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0044325[transmembrane transporter binding] GO:0045163[clustering of voltage-gated potassium channels] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0046923[ER retention sequence binding] GO:0047485[protein N-terminus binding] GO:0071805[potassium ion transmembrane transport] GO:0086008[voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0097623[potassium ion export across plasma membrane] GO:1901379[regulation of potassium ion transmembrane transport] GO:1903766[positive regulation of potassium ion export across plasma membrane] GO:1903818[positive regulation of voltage-gated potassium channel activity]
Q9NS61 [Direct mapping] Kv channel-interacting protein 2
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005244[voltage-gated ion channel activity] GO:0005250[A-type (transient outward) potassium channel activity] GO:0005267[potassium channel activity] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006936[muscle contraction] GO:0007165[signal transduction] GO:0007268[chemical synaptic transmission] GO:0008016[regulation of heart contraction] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0042802[identical protein binding] GO:0044325[transmembrane transporter binding] GO:0045163[clustering of voltage-gated potassium channels] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0046923[ER retention sequence binding] GO:0047485[protein N-terminus binding] GO:0071805[potassium ion transmembrane transport] GO:0086008[voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0097623[potassium ion export across plasma membrane] GO:1901379[regulation of potassium ion transmembrane transport] GO:1903766[positive regulation of potassium ion export across plasma membrane] GO:1903818[positive regulation of voltage-gated potassium channel activity]
Q9NS61 [Direct mapping] Kv channel-interacting protein 2
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005244[voltage-gated ion channel activity] GO:0005250[A-type (transient outward) potassium channel activity] GO:0005267[potassium channel activity] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006936[muscle contraction] GO:0007165[signal transduction] GO:0007268[chemical synaptic transmission] GO:0008016[regulation of heart contraction] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0044325[transmembrane transporter binding] GO:0045163[clustering of voltage-gated potassium channels] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0046923[ER retention sequence binding] GO:0047485[protein N-terminus binding] GO:0071805[potassium ion transmembrane transport] GO:0086008[voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0097623[potassium ion export across plasma membrane] GO:1901379[regulation of potassium ion transmembrane transport] GO:1903766[positive regulation of potassium ion export across plasma membrane] GO:1903818[positive regulation of voltage-gated potassium channel activity]
Q9NS61 [Direct mapping] Kv channel-interacting protein 2
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005244[voltage-gated ion channel activity] GO:0005250[A-type (transient outward) potassium channel activity] GO:0005267[potassium channel activity] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006936[muscle contraction] GO:0007165[signal transduction] GO:0007268[chemical synaptic transmission] GO:0008016[regulation of heart contraction] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0044325[transmembrane transporter binding] GO:0045163[clustering of voltage-gated potassium channels] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0046923[ER retention sequence binding] GO:0047485[protein N-terminus binding] GO:0071805[potassium ion transmembrane transport] GO:0086008[voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0097623[potassium ion export across plasma membrane] GO:1901379[regulation of potassium ion transmembrane transport] GO:1903766[positive regulation of potassium ion export across plasma membrane] GO:1903818[positive regulation of voltage-gated potassium channel activity]
Q9NS61 [Direct mapping] Kv channel-interacting protein 2
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005244[voltage-gated ion channel activity] GO:0005250[A-type (transient outward) potassium channel activity] GO:0005267[potassium channel activity] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006936[muscle contraction] GO:0007165[signal transduction] GO:0007268[chemical synaptic transmission] GO:0008016[regulation of heart contraction] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0030425[dendrite] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0044325[transmembrane transporter binding] GO:0044877[protein-containing complex binding] GO:0045163[clustering of voltage-gated potassium channels] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0046923[ER retention sequence binding] GO:0047485[protein N-terminus binding] GO:0071805[potassium ion transmembrane transport] GO:0086008[voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0097623[potassium ion export across plasma membrane] GO:1901379[regulation of potassium ion transmembrane transport] GO:1903766[positive regulation of potassium ion export across plasma membrane] GO:1903818[positive regulation of voltage-gated potassium channel activity]
Q9NS61 [Direct mapping] Kv channel-interacting protein 2
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005244[voltage-gated ion channel activity] GO:0005250[A-type (transient outward) potassium channel activity] GO:0005267[potassium channel activity] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006936[muscle contraction] GO:0007165[signal transduction] GO:0007268[chemical synaptic transmission] GO:0008016[regulation of heart contraction] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0044325[transmembrane transporter binding] GO:0045163[clustering of voltage-gated potassium channels] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0046923[ER retention sequence binding] GO:0047485[protein N-terminus binding] GO:0071805[potassium ion transmembrane transport] GO:0086008[voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0097623[potassium ion export across plasma membrane] GO:1901379[regulation of potassium ion transmembrane transport] GO:1903766[positive regulation of potassium ion export across plasma membrane] GO:1903818[positive regulation of voltage-gated potassium channel activity]
Q9NS61 [Direct mapping] Kv channel-interacting protein 2
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005244[voltage-gated ion channel activity] GO:0005250[A-type (transient outward) potassium channel activity] GO:0005267[potassium channel activity] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006936[muscle contraction] GO:0007165[signal transduction] GO:0007268[chemical synaptic transmission] GO:0008016[regulation of heart contraction] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0044325[transmembrane transporter binding] GO:0045163[clustering of voltage-gated potassium channels] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0046923[ER retention sequence binding] GO:0047485[protein N-terminus binding] GO:0071805[potassium ion transmembrane transport] GO:0086008[voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0097623[potassium ion export across plasma membrane] GO:1901379[regulation of potassium ion transmembrane transport] GO:1903766[positive regulation of potassium ion export across plasma membrane] GO:1903818[positive regulation of voltage-gated potassium channel activity]
Q9NS61 [Direct mapping] Kv channel-interacting protein 2
Show all
Transporters Accessory Factors Involved in Transport SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0005244[voltage-gated ion channel activity] GO:0005250[A-type (transient outward) potassium channel activity] GO:0005267[potassium channel activity] GO:0005509[calcium ion binding] GO:0005513[detection of calcium ion] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006936[muscle contraction] GO:0007165[signal transduction] GO:0007268[chemical synaptic transmission] GO:0008016[regulation of heart contraction] GO:0008076[voltage-gated potassium channel complex] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0034705[potassium channel complex] GO:0034765[regulation of ion transmembrane transport] GO:0044325[transmembrane transporter binding] GO:0045163[clustering of voltage-gated potassium channels] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0046923[ER retention sequence binding] GO:0047485[protein N-terminus binding] GO:0071805[potassium ion transmembrane transport] GO:0086008[voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization] GO:0086009[membrane repolarization] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0097623[potassium ion export across plasma membrane] GO:1901379[regulation of potassium ion transmembrane transport] GO:1903766[positive regulation of potassium ion export across plasma membrane] GO:1903818[positive regulation of voltage-gated potassium channel activity]