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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q32.1
Chromosome location (bp)
200551497 - 200620751
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis 1,2. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively 3. Regulates cell growth through regulation of cell cycle progression and cytokinesis 4. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 5. During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process 6. Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules 7....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Motor protein
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q15058 [Direct mapping] Kinesin-like protein KIF14
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of the nervous system Congenital malformations of the urinary system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0003777[microtubule motor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005871[kinesin complex] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0007018[microtubule-based movement] GO:0007080[mitotic metaphase plate congression] GO:0008017[microtubule binding] GO:0008284[positive regulation of cell population proliferation] GO:0008574[plus-end-directed microtubule motor activity] GO:0010389[regulation of G2/M transition of mitotic cell cycle] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016887[ATP hydrolysis activity] GO:0019901[protein kinase binding] GO:0021685[cerebellar granular layer structural organization] GO:0021693[cerebellar Purkinje cell layer structural organization] GO:0021695[cerebellar cortex development] GO:0021766[hippocampus development] GO:0021772[olfactory bulb development] GO:0021846[cell proliferation in forebrain] GO:0021987[cerebral cortex development] GO:0030155[regulation of cell adhesion] GO:0030165[PDZ domain binding] GO:0030334[regulation of cell migration] GO:0030496[midbody] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031641[regulation of myelination] GO:0032147[activation of protein kinase activity] GO:0032467[positive regulation of cytokinesis] GO:0032487[regulation of Rap protein signal transduction] GO:0033624[negative regulation of integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0043066[negative regulation of apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0045184[establishment of protein localization] GO:0051233[spindle midzone] GO:0051301[cell division] GO:0090543[Flemming body] GO:1903429[regulation of cell maturation] GO:2000045[regulation of G1/S transition of mitotic cell cycle]
Q15058 [Direct mapping] Kinesin-like protein KIF14
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Cancers Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of the nervous system Congenital malformations of the urinary system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001558[regulation of cell growth] GO:0003777[microtubule motor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005871[kinesin complex] GO:0005874[microtubule] GO:0005886[plasma membrane] GO:0007018[microtubule-based movement] GO:0007080[mitotic metaphase plate congression] GO:0008017[microtubule binding] GO:0008284[positive regulation of cell population proliferation] GO:0008574[plus-end-directed microtubule motor activity] GO:0010389[regulation of G2/M transition of mitotic cell cycle] GO:0015631[tubulin binding] GO:0016020[membrane] GO:0016887[ATP hydrolysis activity] GO:0019901[protein kinase binding] GO:0021685[cerebellar granular layer structural organization] GO:0021693[cerebellar Purkinje cell layer structural organization] GO:0021695[cerebellar cortex development] GO:0021766[hippocampus development] GO:0021772[olfactory bulb development] GO:0021846[cell proliferation in forebrain] GO:0021987[cerebral cortex development] GO:0030155[regulation of cell adhesion] GO:0030165[PDZ domain binding] GO:0030334[regulation of cell migration] GO:0030496[midbody] GO:0031146[SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0031641[regulation of myelination] GO:0032147[activation of protein kinase activity] GO:0032467[positive regulation of cytokinesis] GO:0032487[regulation of Rap protein signal transduction] GO:0033624[negative regulation of integrin activation] GO:0034446[substrate adhesion-dependent cell spreading] GO:0043066[negative regulation of apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043523[regulation of neuron apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0045184[establishment of protein localization] GO:0051233[spindle midzone] GO:0090543[Flemming body] GO:2000045[regulation of G1/S transition of mitotic cell cycle]