We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q43
Chromosome location (bp)
237877864 - 237890922
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Fertilization
Gene summary (Entrez)i
Useful information about the gene from Entrez
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
GO:0002922[positive regulation of humoral immune response] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005886[plasma membrane] GO:0007338[single fertilization] GO:0007339[binding of sperm to zona pellucida] GO:0016020[membrane] GO:0032190[acrosin binding] GO:0035804[structural constituent of egg coat] GO:0035805[egg coat] GO:0042102[positive regulation of T cell proliferation] GO:0042802[identical protein binding] GO:0060468[prevention of polyspermy] GO:0060478[acrosomal vesicle exocytosis] GO:0062023[collagen-containing extracellular matrix] GO:2000344[positive regulation of acrosome reaction] GO:2000360[negative regulation of binding of sperm to zona pellucida]
GO:0002922[positive regulation of humoral immune response] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005886[plasma membrane] GO:0007338[single fertilization] GO:0007339[binding of sperm to zona pellucida] GO:0016020[membrane] GO:0032190[acrosin binding] GO:0035804[structural constituent of egg coat] GO:0035805[egg coat] GO:0042102[positive regulation of T cell proliferation] GO:0042802[identical protein binding] GO:0060468[prevention of polyspermy] GO:0060478[acrosomal vesicle exocytosis] GO:0062023[collagen-containing extracellular matrix] GO:2000344[positive regulation of acrosome reaction] GO:2000360[negative regulation of binding of sperm to zona pellucida]
The Human Protein Atlas project is funded
