GENERAL INFORMATIONi
Gene namei PARK7
Synonyms DJ-1, DJ1, GATD2
Gene descriptioni Parkinsonism associated deglycase
Protein classi Disease related genes
Enzymes
Human disease related genes
Plasma proteins
Potential drug targets
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 1
Cytoband p36.23
Chromosome location (bp) 7954291 - 7985505
Number of transcriptsi 7
Ensembl ENSG00000116288 (version 109)
Entrez gene 11315
HGNC HGNC:16369
UniProt Q99497 (UniProt - Evidence at protein level)
neXtProt NX_Q99497
GeneCards PARK7
Antibodypedia PARK7 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease 1, 2, 3, 4, 5, 6, 7, 8. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway 9, 10, 11, 12, 13, 14. Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals 15, 16. But this function is rebuted by other works 17, 18. As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage 19, 20, 21. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair 22. Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin 23. Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels 24, 25. Displays a very low glyoxalase activity that may reflect its deglycase activity 26, 27, 28. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death 29. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria 30, 31. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking 32. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells 33. In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress 34. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity 35. In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). show less
Molecular function (UniProt)i Chaperone, Hydrolase, Protease, RNA-binding
Biological process (UniProt)i Autophagy, DNA damage, DNA repair, Fertilization, Inflammatory response, Stress response
Ligand (UniProt)i Copper
Gene summary (Entrez)i The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PARK7-201
ENSP00000340278
ENST00000338639
Q99497
[Direct mapping] Parkinson disease protein 7
Show all
V9HWC2
[Target identity:100%; Query identity:100%] Protein deglycase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005102 [signaling receptor binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006281 [DNA repair]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006508 [proteolysis]
GO:0006517 [protein deglycosylation]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007005 [mitochondrion organization]
GO:0007265 [Ras protein signal transduction]
GO:0007338 [single fertilization]
GO:0008233 [peptidase activity]
GO:0008344 [adult locomotory behavior]
GO:0009438 [methylglyoxal metabolic process]
GO:0010273 [detoxification of copper ion]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016532 [superoxide dismutase copper chaperone activity]
GO:0016570 [histone modification]
GO:0016605 [PML body]
GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor]
GO:0016787 [hydrolase activity]
GO:0019249 [lactate biosynthetic process]
GO:0019826 [oxygen sensor activity]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019955 [cytokine binding]
GO:0030073 [insulin secretion]
GO:0030424 [axon]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033182 [regulation of histone ubiquitination]
GO:0033234 [negative regulation of protein sumoylation]
GO:0033864 [positive regulation of NAD(P)H oxidase activity]
GO:0034599 [cellular response to oxidative stress]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035065 [regulation of histone acetylation]
GO:0036470 [tyrosine 3-monooxygenase activator activity]
GO:0036471 [cellular response to glyoxal]
GO:0036478 [L-dopa decarboxylase activator activity]
GO:0036524 [protein deglycase activity]
GO:0036526 [peptidyl-cysteine deglycation]
GO:0036527 [peptidyl-arginine deglycation]
GO:0036528 [peptidyl-lysine deglycation]
GO:0036529 [protein deglycation, glyoxal removal]
GO:0036530 [protein deglycation, methylglyoxal removal]
GO:0036531 [glutathione deglycation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042542 [response to hydrogen peroxide]
GO:0042593 [glucose homeostasis]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044297 [cell body]
GO:0044388 [small protein activating enzyme binding]
GO:0044390 [ubiquitin-like protein conjugating enzyme binding]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045296 [cadherin binding]
GO:0045340 [mercury ion binding]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046295 [glycolate biosynthetic process]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050681 [nuclear androgen receptor binding]
GO:0050727 [regulation of inflammatory response]
GO:0050787 [detoxification of mercury ion]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051583 [dopamine uptake involved in synaptic transmission]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051899 [membrane depolarization]
GO:0051920 [peroxiredoxin activity]
GO:0060081 [membrane hyperpolarization]
GO:0060548 [negative regulation of cell death]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0061727 [methylglyoxal catabolic process to lactate]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070994 [detection of oxidative stress]
GO:0097110 [scaffold protein binding]
GO:0098793 [presynapse]
GO:0098869 [cellular oxidant detoxification]
GO:0106044 [guanine deglycation]
GO:0106045 [guanine deglycation, methylglyoxal removal]
GO:0106046 [guanine deglycation, glyoxal removal]
GO:0110095 [cellular detoxification of aldehyde]
GO:0140041 [cellular detoxification of methylglyoxal]
GO:0140297 [DNA-binding transcription factor binding]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901671 [positive regulation of superoxide dismutase activity]
GO:1901984 [negative regulation of protein acetylation]
GO:1902177 [positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1902903 [regulation of supramolecular fiber organization]
GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903073 [negative regulation of death-inducing signaling complex assembly]
GO:1903094 [negative regulation of protein K48-linked deubiquitination]
GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway]
GO:1903135 [cupric ion binding]
GO:1903136 [cuprous ion binding]
GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity]
GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity]
GO:1903181 [positive regulation of dopamine biosynthetic process]
GO:1903189 [glyoxal metabolic process]
GO:1903190 [glyoxal catabolic process]
GO:1903197 [positive regulation of L-dopa biosynthetic process]
GO:1903200 [positive regulation of L-dopa decarboxylase activity]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903204 [negative regulation of oxidative stress-induced neuron death]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway]
GO:1903427 [negative regulation of reactive oxygen species biosynthetic process]
GO:1903428 [positive regulation of reactive oxygen species biosynthetic process]
GO:1903599 [positive regulation of autophagy of mitochondrion]
GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway]
GO:1990381 [ubiquitin-specific protease binding]
GO:1990422 [glyoxalase (glycolic acid-forming) activity]
GO:2000157 [negative regulation of ubiquitin-specific protease activity]
GO:2000277 [positive regulation of oxidative phosphorylation uncoupler activity]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000825 [positive regulation of androgen receptor activity]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 189 aa
19.9 kDa 		No 0
PARK7-202
ENSP00000366708
ENST00000377488
Q99497
[Direct mapping] Parkinson disease protein 7
Show all
V9HWC2
[Target identity:100%; Query identity:100%] Protein deglycase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005102 [signaling receptor binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006281 [DNA repair]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006508 [proteolysis]
GO:0006517 [protein deglycosylation]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007005 [mitochondrion organization]
GO:0007265 [Ras protein signal transduction]
GO:0007338 [single fertilization]
GO:0008233 [peptidase activity]
GO:0009438 [methylglyoxal metabolic process]
GO:0010273 [detoxification of copper ion]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016532 [superoxide dismutase copper chaperone activity]
GO:0016570 [histone modification]
GO:0016605 [PML body]
GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor]
GO:0016787 [hydrolase activity]
GO:0019249 [lactate biosynthetic process]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019955 [cytokine binding]
GO:0030073 [insulin secretion]
GO:0030424 [axon]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033182 [regulation of histone ubiquitination]
GO:0033234 [negative regulation of protein sumoylation]
GO:0033864 [positive regulation of NAD(P)H oxidase activity]
GO:0034599 [cellular response to oxidative stress]
GO:0035065 [regulation of histone acetylation]
GO:0036470 [tyrosine 3-monooxygenase activator activity]
GO:0036471 [cellular response to glyoxal]
GO:0036478 [L-dopa decarboxylase activator activity]
GO:0036524 [protein deglycase activity]
GO:0036526 [peptidyl-cysteine deglycation]
GO:0036527 [peptidyl-arginine deglycation]
GO:0036528 [peptidyl-lysine deglycation]
GO:0036529 [protein deglycation, glyoxal removal]
GO:0036530 [protein deglycation, methylglyoxal removal]
GO:0036531 [glutathione deglycation]
GO:0042593 [glucose homeostasis]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044388 [small protein activating enzyme binding]
GO:0044390 [ubiquitin-like protein conjugating enzyme binding]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045296 [cadherin binding]
GO:0045340 [mercury ion binding]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046295 [glycolate biosynthetic process]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050681 [nuclear androgen receptor binding]
GO:0050727 [regulation of inflammatory response]
GO:0050787 [detoxification of mercury ion]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060548 [negative regulation of cell death]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0061727 [methylglyoxal catabolic process to lactate]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0097110 [scaffold protein binding]
GO:0098793 [presynapse]
GO:0098869 [cellular oxidant detoxification]
GO:0106044 [guanine deglycation]
GO:0106045 [guanine deglycation, methylglyoxal removal]
GO:0106046 [guanine deglycation, glyoxal removal]
GO:0110095 [cellular detoxification of aldehyde]
GO:0140041 [cellular detoxification of methylglyoxal]
GO:0140297 [DNA-binding transcription factor binding]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901671 [positive regulation of superoxide dismutase activity]
GO:1901984 [negative regulation of protein acetylation]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1902903 [regulation of supramolecular fiber organization]
GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903073 [negative regulation of death-inducing signaling complex assembly]
GO:1903094 [negative regulation of protein K48-linked deubiquitination]
GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway]
GO:1903135 [cupric ion binding]
GO:1903136 [cuprous ion binding]
GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity]
GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity]
GO:1903181 [positive regulation of dopamine biosynthetic process]
GO:1903189 [glyoxal metabolic process]
GO:1903190 [glyoxal catabolic process]
GO:1903197 [positive regulation of L-dopa biosynthetic process]
GO:1903200 [positive regulation of L-dopa decarboxylase activity]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway]
GO:1903427 [negative regulation of reactive oxygen species biosynthetic process]
GO:1903599 [positive regulation of autophagy of mitochondrion]
GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway]
GO:1990381 [ubiquitin-specific protease binding]
GO:1990422 [glyoxalase (glycolic acid-forming) activity]
GO:2000157 [negative regulation of ubiquitin-specific protease activity]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000825 [positive regulation of androgen receptor activity]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 189 aa
19.9 kDa 		No 0
PARK7-203
ENSP00000366711
ENST00000377491
Q99497
[Direct mapping] Parkinson disease protein 7
Show all
V9HWC2
[Target identity:100%; Query identity:100%] Protein deglycase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005102 [signaling receptor binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006281 [DNA repair]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006508 [proteolysis]
GO:0006517 [protein deglycosylation]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007005 [mitochondrion organization]
GO:0007265 [Ras protein signal transduction]
GO:0007338 [single fertilization]
GO:0008233 [peptidase activity]
GO:0009438 [methylglyoxal metabolic process]
GO:0010273 [detoxification of copper ion]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016532 [superoxide dismutase copper chaperone activity]
GO:0016570 [histone modification]
GO:0016605 [PML body]
GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor]
GO:0016787 [hydrolase activity]
GO:0019249 [lactate biosynthetic process]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019955 [cytokine binding]
GO:0030073 [insulin secretion]
GO:0030424 [axon]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033182 [regulation of histone ubiquitination]
GO:0033234 [negative regulation of protein sumoylation]
GO:0033864 [positive regulation of NAD(P)H oxidase activity]
GO:0034599 [cellular response to oxidative stress]
GO:0035065 [regulation of histone acetylation]
GO:0036470 [tyrosine 3-monooxygenase activator activity]
GO:0036471 [cellular response to glyoxal]
GO:0036478 [L-dopa decarboxylase activator activity]
GO:0036524 [protein deglycase activity]
GO:0036526 [peptidyl-cysteine deglycation]
GO:0036527 [peptidyl-arginine deglycation]
GO:0036528 [peptidyl-lysine deglycation]
GO:0036529 [protein deglycation, glyoxal removal]
GO:0036530 [protein deglycation, methylglyoxal removal]
GO:0036531 [glutathione deglycation]
GO:0042593 [glucose homeostasis]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044388 [small protein activating enzyme binding]
GO:0044390 [ubiquitin-like protein conjugating enzyme binding]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045296 [cadherin binding]
GO:0045340 [mercury ion binding]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046295 [glycolate biosynthetic process]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050681 [nuclear androgen receptor binding]
GO:0050727 [regulation of inflammatory response]
GO:0050787 [detoxification of mercury ion]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060548 [negative regulation of cell death]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0061727 [methylglyoxal catabolic process to lactate]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0097110 [scaffold protein binding]
GO:0098793 [presynapse]
GO:0098869 [cellular oxidant detoxification]
GO:0106044 [guanine deglycation]
GO:0106045 [guanine deglycation, methylglyoxal removal]
GO:0106046 [guanine deglycation, glyoxal removal]
GO:0110095 [cellular detoxification of aldehyde]
GO:0140041 [cellular detoxification of methylglyoxal]
GO:0140297 [DNA-binding transcription factor binding]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901671 [positive regulation of superoxide dismutase activity]
GO:1901984 [negative regulation of protein acetylation]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1902903 [regulation of supramolecular fiber organization]
GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903073 [negative regulation of death-inducing signaling complex assembly]
GO:1903094 [negative regulation of protein K48-linked deubiquitination]
GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway]
GO:1903135 [cupric ion binding]
GO:1903136 [cuprous ion binding]
GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity]
GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity]
GO:1903181 [positive regulation of dopamine biosynthetic process]
GO:1903189 [glyoxal metabolic process]
GO:1903190 [glyoxal catabolic process]
GO:1903197 [positive regulation of L-dopa biosynthetic process]
GO:1903200 [positive regulation of L-dopa decarboxylase activity]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway]
GO:1903427 [negative regulation of reactive oxygen species biosynthetic process]
GO:1903599 [positive regulation of autophagy of mitochondrion]
GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway]
GO:1990381 [ubiquitin-specific protease binding]
GO:1990422 [glyoxalase (glycolic acid-forming) activity]
GO:2000157 [negative regulation of ubiquitin-specific protease activity]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000825 [positive regulation of androgen receptor activity]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 189 aa
19.9 kDa 		No 0
PARK7-204
ENSP00000466242
ENST00000377493
K7ELW0
[Direct mapping] Parkinson disease protein 7
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006914 [autophagy]
Show all
 169 aa
17.9 kDa 		No 0
PARK7-207
ENSP00000466756
ENST00000469225
K7EN27
[Direct mapping] Protein deglycase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006914 [autophagy]
GO:0007338 [single fertilization]
GO:0045121 [membrane raft]
Show all
 160 aa
17 kDa 		No 0
PARK7-208
ENSP00000465404
ENST00000493373
Q99497
[Direct mapping] Parkinson disease protein 7
Show all
V9HWC2
[Target identity:100%; Query identity:100%] Protein deglycase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005102 [signaling receptor binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006281 [DNA repair]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006508 [proteolysis]
GO:0006517 [protein deglycosylation]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007005 [mitochondrion organization]
GO:0007265 [Ras protein signal transduction]
GO:0007338 [single fertilization]
GO:0008233 [peptidase activity]
GO:0009438 [methylglyoxal metabolic process]
GO:0010273 [detoxification of copper ion]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016532 [superoxide dismutase copper chaperone activity]
GO:0016570 [histone modification]
GO:0016605 [PML body]
GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor]
GO:0016787 [hydrolase activity]
GO:0019249 [lactate biosynthetic process]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019955 [cytokine binding]
GO:0030073 [insulin secretion]
GO:0030424 [axon]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033182 [regulation of histone ubiquitination]
GO:0033234 [negative regulation of protein sumoylation]
GO:0033864 [positive regulation of NAD(P)H oxidase activity]
GO:0034599 [cellular response to oxidative stress]
GO:0035065 [regulation of histone acetylation]
GO:0036470 [tyrosine 3-monooxygenase activator activity]
GO:0036471 [cellular response to glyoxal]
GO:0036478 [L-dopa decarboxylase activator activity]
GO:0036524 [protein deglycase activity]
GO:0036526 [peptidyl-cysteine deglycation]
GO:0036527 [peptidyl-arginine deglycation]
GO:0036528 [peptidyl-lysine deglycation]
GO:0036529 [protein deglycation, glyoxal removal]
GO:0036530 [protein deglycation, methylglyoxal removal]
GO:0036531 [glutathione deglycation]
GO:0042593 [glucose homeostasis]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044388 [small protein activating enzyme binding]
GO:0044390 [ubiquitin-like protein conjugating enzyme binding]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045296 [cadherin binding]
GO:0045340 [mercury ion binding]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046295 [glycolate biosynthetic process]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050681 [nuclear androgen receptor binding]
GO:0050727 [regulation of inflammatory response]
GO:0050787 [detoxification of mercury ion]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060548 [negative regulation of cell death]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0061727 [methylglyoxal catabolic process to lactate]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0097110 [scaffold protein binding]
GO:0098793 [presynapse]
GO:0098869 [cellular oxidant detoxification]
GO:0106044 [guanine deglycation]
GO:0106045 [guanine deglycation, methylglyoxal removal]
GO:0106046 [guanine deglycation, glyoxal removal]
GO:0110095 [cellular detoxification of aldehyde]
GO:0140041 [cellular detoxification of methylglyoxal]
GO:0140297 [DNA-binding transcription factor binding]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901671 [positive regulation of superoxide dismutase activity]
GO:1901984 [negative regulation of protein acetylation]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1902903 [regulation of supramolecular fiber organization]
GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903073 [negative regulation of death-inducing signaling complex assembly]
GO:1903094 [negative regulation of protein K48-linked deubiquitination]
GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway]
GO:1903135 [cupric ion binding]
GO:1903136 [cuprous ion binding]
GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity]
GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity]
GO:1903181 [positive regulation of dopamine biosynthetic process]
GO:1903189 [glyoxal metabolic process]
GO:1903190 [glyoxal catabolic process]
GO:1903197 [positive regulation of L-dopa biosynthetic process]
GO:1903200 [positive regulation of L-dopa decarboxylase activity]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway]
GO:1903427 [negative regulation of reactive oxygen species biosynthetic process]
GO:1903599 [positive regulation of autophagy of mitochondrion]
GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway]
GO:1990381 [ubiquitin-specific protease binding]
GO:1990422 [glyoxalase (glycolic acid-forming) activity]
GO:2000157 [negative regulation of ubiquitin-specific protease activity]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000825 [positive regulation of androgen receptor activity]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 189 aa
19.9 kDa 		No 0
PARK7-209
ENSP00000418770
ENST00000493678
Q99497
[Direct mapping] Parkinson disease protein 7
Show all
V9HWC2
[Target identity:100%; Query identity:100%] Protein deglycase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Potential drug targets
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005102 [signaling receptor binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006281 [DNA repair]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006508 [proteolysis]
GO:0006517 [protein deglycosylation]
GO:0006914 [autophagy]
GO:0006954 [inflammatory response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007005 [mitochondrion organization]
GO:0007265 [Ras protein signal transduction]
GO:0007338 [single fertilization]
GO:0008233 [peptidase activity]
GO:0009438 [methylglyoxal metabolic process]
GO:0010273 [detoxification of copper ion]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016532 [superoxide dismutase copper chaperone activity]
GO:0016570 [histone modification]
GO:0016605 [PML body]
GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor]
GO:0016787 [hydrolase activity]
GO:0019249 [lactate biosynthetic process]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019955 [cytokine binding]
GO:0030073 [insulin secretion]
GO:0030424 [axon]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0032091 [negative regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033182 [regulation of histone ubiquitination]
GO:0033234 [negative regulation of protein sumoylation]
GO:0033864 [positive regulation of NAD(P)H oxidase activity]
GO:0034599 [cellular response to oxidative stress]
GO:0035065 [regulation of histone acetylation]
GO:0036470 [tyrosine 3-monooxygenase activator activity]
GO:0036471 [cellular response to glyoxal]
GO:0036478 [L-dopa decarboxylase activator activity]
GO:0036524 [protein deglycase activity]
GO:0036526 [peptidyl-cysteine deglycation]
GO:0036527 [peptidyl-arginine deglycation]
GO:0036528 [peptidyl-lysine deglycation]
GO:0036529 [protein deglycation, glyoxal removal]
GO:0036530 [protein deglycation, methylglyoxal removal]
GO:0036531 [glutathione deglycation]
GO:0042593 [glucose homeostasis]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044388 [small protein activating enzyme binding]
GO:0044390 [ubiquitin-like protein conjugating enzyme binding]
GO:0044877 [protein-containing complex binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045296 [cadherin binding]
GO:0045340 [mercury ion binding]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046295 [glycolate biosynthetic process]
GO:0046826 [negative regulation of protein export from nucleus]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050681 [nuclear androgen receptor binding]
GO:0050727 [regulation of inflammatory response]
GO:0050787 [detoxification of mercury ion]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060548 [negative regulation of cell death]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0061727 [methylglyoxal catabolic process to lactate]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0097110 [scaffold protein binding]
GO:0098793 [presynapse]
GO:0098869 [cellular oxidant detoxification]
GO:0106044 [guanine deglycation]
GO:0106045 [guanine deglycation, methylglyoxal removal]
GO:0106046 [guanine deglycation, glyoxal removal]
GO:0110095 [cellular detoxification of aldehyde]
GO:0140041 [cellular detoxification of methylglyoxal]
GO:0140297 [DNA-binding transcription factor binding]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1901215 [negative regulation of neuron death]
GO:1901671 [positive regulation of superoxide dismutase activity]
GO:1901984 [negative regulation of protein acetylation]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1902903 [regulation of supramolecular fiber organization]
GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone]
GO:1903073 [negative regulation of death-inducing signaling complex assembly]
GO:1903094 [negative regulation of protein K48-linked deubiquitination]
GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway]
GO:1903135 [cupric ion binding]
GO:1903136 [cuprous ion binding]
GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity]
GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity]
GO:1903181 [positive regulation of dopamine biosynthetic process]
GO:1903189 [glyoxal metabolic process]
GO:1903190 [glyoxal catabolic process]
GO:1903197 [positive regulation of L-dopa biosynthetic process]
GO:1903200 [positive regulation of L-dopa decarboxylase activity]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway]
GO:1903427 [negative regulation of reactive oxygen species biosynthetic process]
GO:1903599 [positive regulation of autophagy of mitochondrion]
GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway]
GO:1990381 [ubiquitin-specific protease binding]
GO:1990422 [glyoxalase (glycolic acid-forming) activity]
GO:2000157 [negative regulation of ubiquitin-specific protease activity]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000825 [positive regulation of androgen receptor activity]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 189 aa
19.9 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
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