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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q26.1
Chromosome location (bp)
167683298 - 167734939
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity 1. Important for cell migration, and for normal structure and assembly of the Golgi complex 2. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation 3. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis, Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9BUL8 [Direct mapping] Programmed cell death protein 10
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001525[angiogenesis] GO:0003158[endothelium development] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0030335[positive regulation of cell migration] GO:0032874[positive regulation of stress-activated MAPK cascade] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0036481[intrinsic apoptotic signaling pathway in response to hydrogen peroxide] GO:0042542[response to hydrogen peroxide] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043406[positive regulation of MAP kinase activity] GO:0044319[wound healing, spreading of cells] GO:0045747[positive regulation of Notch signaling pathway] GO:0045765[regulation of angiogenesis] GO:0047485[protein N-terminus binding] GO:0050821[protein stabilization] GO:0051683[establishment of Golgi localization] GO:0070062[extracellular exosome] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0090168[Golgi reassembly] GO:0090316[positive regulation of intracellular protein transport] GO:0090443[FAR/SIN/STRIPAK complex] GO:1903358[regulation of Golgi organization] GO:1903588[negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1990830[cellular response to leukemia inhibitory factor]
Q9BUL8 [Direct mapping] Programmed cell death protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001525[angiogenesis] GO:0003158[endothelium development] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0030335[positive regulation of cell migration] GO:0032874[positive regulation of stress-activated MAPK cascade] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0036481[intrinsic apoptotic signaling pathway in response to hydrogen peroxide] GO:0042542[response to hydrogen peroxide] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043406[positive regulation of MAP kinase activity] GO:0044319[wound healing, spreading of cells] GO:0045747[positive regulation of Notch signaling pathway] GO:0045765[regulation of angiogenesis] GO:0047485[protein N-terminus binding] GO:0050821[protein stabilization] GO:0051683[establishment of Golgi localization] GO:0070062[extracellular exosome] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0090168[Golgi reassembly] GO:0090316[positive regulation of intracellular protein transport] GO:0090443[FAR/SIN/STRIPAK complex] GO:1903358[regulation of Golgi organization] GO:1903588[negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
C9JND6 [Direct mapping] Programmed cell death protein 10
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
C9J932 [Direct mapping] Programmed cell death protein 10
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
Q9BUL8 [Direct mapping] Programmed cell death protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0001525[angiogenesis] GO:0003158[endothelium development] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0030335[positive regulation of cell migration] GO:0032874[positive regulation of stress-activated MAPK cascade] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0036481[intrinsic apoptotic signaling pathway in response to hydrogen peroxide] GO:0042542[response to hydrogen peroxide] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043406[positive regulation of MAP kinase activity] GO:0044319[wound healing, spreading of cells] GO:0045747[positive regulation of Notch signaling pathway] GO:0045765[regulation of angiogenesis] GO:0047485[protein N-terminus binding] GO:0050821[protein stabilization] GO:0051683[establishment of Golgi localization] GO:0070062[extracellular exosome] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0090168[Golgi reassembly] GO:0090316[positive regulation of intracellular protein transport] GO:0090443[FAR/SIN/STRIPAK complex] GO:1903358[regulation of Golgi organization] GO:1903588[negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
C9J6F3 [Direct mapping] Programmed cell death protein 10
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
Q9BUL8 [Direct mapping] Programmed cell death protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001525[angiogenesis] GO:0003158[endothelium development] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0030335[positive regulation of cell migration] GO:0032874[positive regulation of stress-activated MAPK cascade] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0036481[intrinsic apoptotic signaling pathway in response to hydrogen peroxide] GO:0042542[response to hydrogen peroxide] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043406[positive regulation of MAP kinase activity] GO:0044319[wound healing, spreading of cells] GO:0045747[positive regulation of Notch signaling pathway] GO:0045765[regulation of angiogenesis] GO:0047485[protein N-terminus binding] GO:0050821[protein stabilization] GO:0051683[establishment of Golgi localization] GO:0070062[extracellular exosome] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0090168[Golgi reassembly] GO:0090316[positive regulation of intracellular protein transport] GO:0090443[FAR/SIN/STRIPAK complex] GO:1903358[regulation of Golgi organization] GO:1903588[negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
C9J5C3 [Direct mapping] Programmed cell death protein 10
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
H7C5M9 [Direct mapping] Programmed cell death protein 10
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
C9J6F3 [Direct mapping] Programmed cell death protein 10
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
C9JSA3 [Direct mapping] Programmed cell death protein 10
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
C9J363 [Direct mapping] Programmed cell death 10, isoform CRA_b; Programmed cell death protein 10
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
Q9BUL8 [Direct mapping] Programmed cell death protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0001525[angiogenesis] GO:0003158[endothelium development] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0019901[protein kinase binding] GO:0030335[positive regulation of cell migration] GO:0032874[positive regulation of stress-activated MAPK cascade] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0036481[intrinsic apoptotic signaling pathway in response to hydrogen peroxide] GO:0042542[response to hydrogen peroxide] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043406[positive regulation of MAP kinase activity] GO:0044319[wound healing, spreading of cells] GO:0045747[positive regulation of Notch signaling pathway] GO:0045765[regulation of angiogenesis] GO:0047485[protein N-terminus binding] GO:0050821[protein stabilization] GO:0051683[establishment of Golgi localization] GO:0070062[extracellular exosome] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:0090168[Golgi reassembly] GO:0090316[positive regulation of intracellular protein transport] GO:0090443[FAR/SIN/STRIPAK complex] GO:1903358[regulation of Golgi organization] GO:1903588[negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
The Human Protein Atlas project is funded
