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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
p13.31
Chromosome location (bp)
6946468 - 6961316
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protein phosphatase
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P29350 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 6
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000278[mitotic cell cycle] GO:0001784[phosphotyrosine residue binding] GO:0002244[hematopoietic progenitor cell differentiation] GO:0002924[negative regulation of humoral immune response mediated by circulating immunoglobulin] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004726[non-membrane spanning protein tyrosine phosphatase activity] GO:0005001[transmembrane receptor protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005911[cell-cell junction] GO:0006470[protein dephosphorylation] GO:0007186[G protein-coupled receptor signaling pathway] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0017124[SH3 domain binding] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0030154[cell differentiation] GO:0030220[platelet formation] GO:0031295[T cell costimulation] GO:0032715[negative regulation of interleukin-6 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032991[protein-containing complex] GO:0033007[negative regulation of mast cell activation involved in immune response] GO:0033277[abortive mitotic cell cycle] GO:0033630[positive regulation of cell adhesion mediated by integrin] GO:0035335[peptidyl-tyrosine dephosphorylation] GO:0035556[intracellular signal transduction] GO:0035580[specific granule lumen] GO:0035855[megakaryocyte development] GO:0042098[T cell proliferation] GO:0042105[alpha-beta T cell receptor complex] GO:0042130[negative regulation of T cell proliferation] GO:0042169[SH2 domain binding] GO:0042267[natural killer cell mediated cytotoxicity] GO:0042981[regulation of apoptotic process] GO:0043407[negative regulation of MAP kinase activity] GO:0043409[negative regulation of MAPK cascade] GO:0045577[regulation of B cell differentiation] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0050839[cell adhesion molecule binding] GO:0050852[T cell receptor signaling pathway] GO:0050853[B cell receptor signaling pathway] GO:0050860[negative regulation of T cell receptor signaling pathway] GO:0051279[regulation of release of sequestered calcium ion into cytosol] GO:0060338[regulation of type I interferon-mediated signaling pathway] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070527[platelet aggregation] GO:0071310[cellular response to organic substance] GO:0140031[phosphorylation-dependent protein binding] GO:1904724[tertiary granule lumen] GO:1905867[epididymis development] GO:2000045[regulation of G1/S transition of mitotic cell cycle]
P29350 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 6
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Q53XS4 [Target identity:100%; Query identity:100%] Tyrosine-protein phosphatase non-receptor type
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000278[mitotic cell cycle] GO:0001784[phosphotyrosine residue binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004726[non-membrane spanning protein tyrosine phosphatase activity] GO:0005001[transmembrane receptor protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0007186[G protein-coupled receptor signaling pathway] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0030154[cell differentiation] GO:0031295[T cell costimulation] GO:0032715[negative regulation of interleukin-6 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032991[protein-containing complex] GO:0035335[peptidyl-tyrosine dephosphorylation] GO:0035556[intracellular signal transduction] GO:0035580[specific granule lumen] GO:0042981[regulation of apoptotic process] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0060338[regulation of type I interferon-mediated signaling pathway] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0071310[cellular response to organic substance] GO:0140031[phosphorylation-dependent protein binding] GO:1904724[tertiary granule lumen] GO:2000045[regulation of G1/S transition of mitotic cell cycle]
P29350 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 6
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278[mitotic cell cycle] GO:0001784[phosphotyrosine residue binding] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004726[non-membrane spanning protein tyrosine phosphatase activity] GO:0005001[transmembrane receptor protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0007186[G protein-coupled receptor signaling pathway] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0030154[cell differentiation] GO:0031295[T cell costimulation] GO:0032715[negative regulation of interleukin-6 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032991[protein-containing complex] GO:0035335[peptidyl-tyrosine dephosphorylation] GO:0035556[intracellular signal transduction] GO:0035580[specific granule lumen] GO:0042981[regulation of apoptotic process] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0060338[regulation of type I interferon-mediated signaling pathway] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0071310[cellular response to organic substance] GO:0140031[phosphorylation-dependent protein binding] GO:1904724[tertiary granule lumen] GO:2000045[regulation of G1/S transition of mitotic cell cycle]
The Human Protein Atlas project is funded
