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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
p13.1
Chromosome location (bp)
12685498 - 12722369
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA 1. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protein kinase inhibitor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of the digestive system Cancers of male genital organs Cancers of endocrine organs Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082[G1/S transition of mitotic cell cycle] GO:0001666[response to hypoxia] GO:0001890[placenta development] GO:0004860[protein kinase inhibitor activity] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0006813[potassium ion transport] GO:0006915[apoptotic process] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049[cell cycle] GO:0007096[regulation of exit from mitosis] GO:0007219[Notch signaling pathway] GO:0007346[regulation of mitotic cell cycle] GO:0007507[heart development] GO:0007605[sensory perception of sound] GO:0008219[cell death] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0009749[response to glucose] GO:0010942[positive regulation of cell death] GO:0014070[response to organic cyclic compound] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030332[cyclin binding] GO:0030544[Hsp70 protein binding] GO:0031116[positive regulation of microtubule polymerization] GO:0031464[Cul4A-RING E3 ubiquitin ligase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032355[response to estradiol] GO:0032991[protein-containing complex] GO:0033673[negative regulation of kinase activity] GO:0042127[regulation of cell population proliferation] GO:0042326[negative regulation of phosphorylation] GO:0043200[response to amino acid] GO:0043231[intracellular membrane-bounded organelle] GO:0043434[response to peptide hormone] GO:0044877[protein-containing complex binding] GO:0045732[positive regulation of protein catabolic process] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045930[negative regulation of mitotic cell cycle] GO:0046686[response to cadmium ion] GO:0048102[autophagic cell death] GO:0048839[inner ear development] GO:0050680[negative regulation of epithelial cell proliferation] GO:0051087[chaperone binding] GO:0051168[nuclear export] GO:0051179[localization] GO:0051726[regulation of cell cycle] GO:0060090[molecular adaptor activity] GO:0060255[regulation of macromolecule metabolic process] GO:0060767[epithelial cell proliferation involved in prostate gland development] GO:0060770[negative regulation of epithelial cell proliferation involved in prostate gland development] GO:0071236[cellular response to antibiotic] GO:0071285[cellular response to lithium ion] GO:0071407[cellular response to organic cyclic compound] GO:0071456[cellular response to hypoxia] GO:0090398[cellular senescence] GO:0140678[molecular function inhibitor activity] GO:1902746[regulation of lens fiber cell differentiation] GO:1902806[regulation of cell cycle G1/S phase transition] GO:1902807[negative regulation of cell cycle G1/S phase transition] GO:1904019[epithelial cell apoptotic process] GO:1904030[negative regulation of cyclin-dependent protein kinase activity] GO:1904036[negative regulation of epithelial cell apoptotic process] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1905179[negative regulation of cardiac muscle tissue regeneration] GO:1990757[ubiquitin ligase activator activity] GO:2000045[regulation of G1/S transition of mitotic cell cycle]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of male genital organs Cancers of endocrine organs Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
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GO:0004860[protein kinase inhibitor activity] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0042127[regulation of cell population proliferation] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051726[regulation of cell cycle] GO:0060255[regulation of macromolecule metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of male genital organs Cancers of endocrine organs Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
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GO:0004860[protein kinase inhibitor activity] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0042127[regulation of cell population proliferation] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0051726[regulation of cell cycle] GO:0060255[regulation of macromolecule metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Cancers of the digestive system Cancers of male genital organs Cancers of endocrine organs Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082[G1/S transition of mitotic cell cycle] GO:0004860[protein kinase inhibitor activity] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049[cell cycle] GO:0007507[heart development] GO:0008285[negative regulation of cell population proliferation] GO:0010942[positive regulation of cell death] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019901[protein kinase binding] GO:0019903[protein phosphatase binding] GO:0030308[negative regulation of cell growth] GO:0030332[cyclin binding] GO:0031464[Cul4A-RING E3 ubiquitin ligase complex] GO:0031625[ubiquitin protein ligase binding] GO:0033673[negative regulation of kinase activity] GO:0042127[regulation of cell population proliferation] GO:0042326[negative regulation of phosphorylation] GO:0043231[intracellular membrane-bounded organelle] GO:0044877[protein-containing complex binding] GO:0045732[positive regulation of protein catabolic process] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045930[negative regulation of mitotic cell cycle] GO:0048102[autophagic cell death] GO:0051087[chaperone binding] GO:0051168[nuclear export] GO:0051179[localization] GO:0051726[regulation of cell cycle] GO:0060090[molecular adaptor activity] GO:0060255[regulation of macromolecule metabolic process] GO:0071285[cellular response to lithium ion] GO:0090398[cellular senescence] GO:0140678[molecular function inhibitor activity] GO:1902806[regulation of cell cycle G1/S phase transition] GO:1902807[negative regulation of cell cycle G1/S phase transition] GO:1904030[negative regulation of cyclin-dependent protein kinase activity] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1905179[negative regulation of cardiac muscle tissue regeneration] GO:1990757[ubiquitin ligase activator activity] GO:2000045[regulation of G1/S transition of mitotic cell cycle]
The Human Protein Atlas project is funded
