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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q24
Chromosome location (bp)
102794383 - 102868896
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins 1,2,3,4,5,6. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- linked polyubiquitination 7,8,9,10,11. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation 12. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin 13. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin 14. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA 15. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase 16. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair 17. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus 18. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53 19,20. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes 21. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction 22. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production 23. Together with ZNF598, catalyzes ubiquitination of 40S ribosomal proteins in response to ribosome collisions 24. In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 25....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, DNA damage, DNA repair, Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0006513[protein monoubiquitination] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030514[negative regulation of BMP signaling pathway] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070062[extracellular exosome] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1903955[positive regulation of protein targeting to mitochondrion]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0006513[protein monoubiquitination] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030514[negative regulation of BMP signaling pathway] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070062[extracellular exosome] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1903955[positive regulation of protein targeting to mitochondrion]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0006513[protein monoubiquitination] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030514[negative regulation of BMP signaling pathway] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070062[extracellular exosome] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1903955[positive regulation of protein targeting to mitochondrion]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0006513[protein monoubiquitination] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030514[negative regulation of BMP signaling pathway] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070062[extracellular exosome] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1903955[positive regulation of protein targeting to mitochondrion]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0032446[protein modification by small protein conjugation]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0006513[protein monoubiquitination] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030514[negative regulation of BMP signaling pathway] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070062[extracellular exosome] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1903955[positive regulation of protein targeting to mitochondrion]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0006513[protein monoubiquitination] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030514[negative regulation of BMP signaling pathway] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070062[extracellular exosome] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1903955[positive regulation of protein targeting to mitochondrion]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0006513[protein monoubiquitination] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030514[negative regulation of BMP signaling pathway] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070062[extracellular exosome] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1903955[positive regulation of protein targeting to mitochondrion]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0006513[protein monoubiquitination] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030514[negative regulation of BMP signaling pathway] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070062[extracellular exosome] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1903955[positive regulation of protein targeting to mitochondrion]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006281[DNA repair] GO:0006513[protein monoubiquitination] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010008[endosome membrane] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0030514[negative regulation of BMP signaling pathway] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0051865[protein autoubiquitination] GO:0061630[ubiquitin protein ligase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070062[extracellular exosome] GO:0070936[protein K48-linked ubiquitination] GO:0070979[protein K11-linked ubiquitination] GO:1903955[positive regulation of protein targeting to mitochondrion]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0032446[protein modification by small protein conjugation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0032446[protein modification by small protein conjugation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0032446[protein modification by small protein conjugation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0032446[protein modification by small protein conjugation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0032446[protein modification by small protein conjugation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0032446[protein modification by small protein conjugation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC
Show all
GO:0000166[nucleotide binding] GO:0005524[ATP binding] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0032446[protein modification by small protein conjugation]
The Human Protein Atlas project is funded
