We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.3
Chromosome location (bp)
1344275 - 1400222
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif 1. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm 2. Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI 3. Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection 4. Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination 5....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
V9HW98 [Target identity:100%; Query identity:100%] Epididymis luminal protein 2
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165[MAPK cascade] GO:0001764[neuron migration] GO:0003064[regulation of heart rate by hormone] GO:0003723[RNA binding] GO:0005246[calcium channel regulator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006605[protein targeting] GO:0007165[signal transduction] GO:0007346[regulation of mitotic cell cycle] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0019899[enzyme binding] GO:0019903[protein phosphatase binding] GO:0019904[protein domain specific binding] GO:0021762[substantia nigra development] GO:0021766[hippocampus development] GO:0021987[cerebral cortex development] GO:0023026[MHC class II protein complex binding] GO:0031625[ubiquitin protein ligase binding] GO:0034504[protein localization to nucleus] GO:0034605[cellular response to heat] GO:0035308[negative regulation of protein dephosphorylation] GO:0035556[intracellular signal transduction] GO:0042470[melanosome] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0044325[transmembrane transporter binding] GO:0045296[cadherin binding] GO:0046827[positive regulation of protein export from nucleus] GO:0046982[protein heterodimerization activity] GO:0050815[phosphoserine residue binding] GO:0051219[phosphoprotein binding] GO:0051480[regulation of cytosolic calcium ion concentration] GO:0060306[regulation of membrane repolarization] GO:0070062[extracellular exosome] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0086091[regulation of heart rate by cardiac conduction] GO:0097110[scaffold protein binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:1901020[negative regulation of calcium ion transmembrane transporter activity] GO:1902309[negative regulation of peptidyl-serine dephosphorylation] GO:1905913[negative regulation of calcium ion export across plasma membrane]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165[MAPK cascade] GO:0003064[regulation of heart rate by hormone] GO:0003723[RNA binding] GO:0005246[calcium channel regulator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0007165[signal transduction] GO:0007346[regulation of mitotic cell cycle] GO:0015459[potassium channel regulator activity] GO:0016020[membrane] GO:0019899[enzyme binding] GO:0021762[substantia nigra development] GO:0023026[MHC class II protein complex binding] GO:0031625[ubiquitin protein ligase binding] GO:0034504[protein localization to nucleus] GO:0034605[cellular response to heat] GO:0035556[intracellular signal transduction] GO:0042470[melanosome] GO:0042802[identical protein binding] GO:0042826[histone deacetylase binding] GO:0044325[transmembrane transporter binding] GO:0045296[cadherin binding] GO:0046827[positive regulation of protein export from nucleus] GO:0046982[protein heterodimerization activity] GO:0050815[phosphoserine residue binding] GO:0051219[phosphoprotein binding] GO:0051480[regulation of cytosolic calcium ion concentration] GO:0060306[regulation of membrane repolarization] GO:0070062[extracellular exosome] GO:0086013[membrane repolarization during cardiac muscle cell action potential] GO:0086091[regulation of heart rate by cardiac conduction] GO:0097110[scaffold protein binding] GO:1901016[regulation of potassium ion transmembrane transporter activity] GO:1901020[negative regulation of calcium ion transmembrane transporter activity] GO:1902309[negative regulation of peptidyl-serine dephosphorylation] GO:1905913[negative regulation of calcium ion export across plasma membrane]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
