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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Protein kinase cAMP-dependent type I regulatory subunit alpha
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q24.2
Chromosome location (bp)
68511780 - 68551319
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
cAMP, cAMP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
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B2R5T5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0046007[negative regulation of activated T cell proliferation] GO:0097546[ciliary base] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
Show all
B2R5T5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0046007[negative regulation of activated T cell proliferation] GO:0097546[ciliary base] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
Show all
B2R5T5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0046007[negative regulation of activated T cell proliferation] GO:0097546[ciliary base] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
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K7EIE5 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit B2R5T5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0046007[negative regulation of activated T cell proliferation] GO:0097546[ciliary base] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
K7EQK3 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
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K7EPB2 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0046007[negative regulation of activated T cell proliferation] GO:0097546[ciliary base] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
Show all
B2R5T5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0046007[negative regulation of activated T cell proliferation] GO:0097546[ciliary base] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
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K7EJ40 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit B2R5T5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0046007[negative regulation of activated T cell proliferation] GO:0097546[ciliary base] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0046007[negative regulation of activated T cell proliferation] GO:0097546[ciliary base] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
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K7EK41 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit B2R5T5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0046007[negative regulation of activated T cell proliferation] GO:0097546[ciliary base] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
Show all
B2R5T5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001707[mesoderm formation] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005771[multivesicular body] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006469[negative regulation of protein kinase activity] GO:0007189[adenylate cyclase-activating G protein-coupled receptor signaling pathway] GO:0007507[heart development] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031594[neuromuscular junction] GO:0031625[ubiquitin protein ligase binding] GO:0032024[positive regulation of insulin secretion] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0045202[synapse] GO:0045214[sarcomere organization] GO:0046007[negative regulation of activated T cell proliferation] GO:0060038[cardiac muscle cell proliferation] GO:0097224[sperm connecting piece] GO:0097546[ciliary base] GO:0098978[glutamatergic synapse] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
K7EPR5 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
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K7EMU2 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit B2R5T5 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001772[immunological synapse] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005930[axoneme] GO:0005952[cAMP-dependent protein kinase complex] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019904[protein domain specific binding] GO:0030552[cAMP binding] GO:0031588[nucleotide-activated protein kinase complex] GO:0031625[ubiquitin protein ligase binding] GO:0032991[protein-containing complex] GO:0034236[protein kinase A catalytic subunit binding] GO:0035556[intracellular signal transduction] GO:0044853[plasma membrane raft] GO:0046007[negative regulation of activated T cell proliferation] GO:0097546[ciliary base] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
K7EM13 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Adrenal gland diseases Other diseases Others Protein evidence (Ezkurdia et al 2014)
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