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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q21.32
Chromosome location (bp)
49210411 - 49223225
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0002357[defense response to tumor cell] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0010593[negative regulation of lamellipodium assembly] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0017124[SH3 domain binding] GO:0030027[lamellipodium] GO:0030334[regulation of cell migration] GO:0031209[SCAR complex] GO:0042802[identical protein binding] GO:0043197[dendritic spine] GO:0043198[dendritic shaft] GO:0051015[actin filament binding] GO:0061001[regulation of dendritic spine morphogenesis] GO:0099151[regulation of postsynaptic density assembly] GO:0110165[cellular anatomical entity] GO:1900028[negative regulation of ruffle assembly] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000249[regulation of actin cytoskeleton reorganization] GO:2000774[positive regulation of cellular senescence]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002357[defense response to tumor cell] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0010593[negative regulation of lamellipodium assembly] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0017124[SH3 domain binding] GO:0030027[lamellipodium] GO:0030334[regulation of cell migration] GO:0031209[SCAR complex] GO:0042802[identical protein binding] GO:0043197[dendritic spine] GO:0043198[dendritic shaft] GO:0051015[actin filament binding] GO:0061001[regulation of dendritic spine morphogenesis] GO:0099151[regulation of postsynaptic density assembly] GO:0110165[cellular anatomical entity] GO:1900028[negative regulation of ruffle assembly] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000249[regulation of actin cytoskeleton reorganization] GO:2000774[positive regulation of cellular senescence]
The Human Protein Atlas project is funded
