We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
p13.3
Chromosome location (bp)
35605262 - 35610041
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin 1. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 2. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q15569 [Direct mapping] Dual specificity testis-specific protein kinase 1
Show all
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001934[positive regulation of protein phosphorylation] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006468[protein phosphorylation] GO:0007283[spermatogenesis] GO:0008022[protein C-terminus binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019901[protein kinase binding] GO:0030027[lamellipodium] GO:0030036[actin cytoskeleton organization] GO:0031410[cytoplasmic vesicle] GO:0031953[negative regulation of protein autophosphorylation] GO:0032880[regulation of protein localization] GO:0032956[regulation of actin cytoskeleton organization] GO:0042326[negative regulation of phosphorylation] GO:0042995[cell projection] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051496[positive regulation of stress fiber assembly] GO:0051650[establishment of vesicle localization] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0090521[podocyte cell migration] GO:0106310[protein serine kinase activity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1900182[positive regulation of protein localization to nucleus] GO:1902018[negative regulation of cilium assembly]
Q15569 [Direct mapping] Dual specificity testis-specific protein kinase 1
Show all
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001934[positive regulation of protein phosphorylation] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006468[protein phosphorylation] GO:0007283[spermatogenesis] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030027[lamellipodium] GO:0030036[actin cytoskeleton organization] GO:0031410[cytoplasmic vesicle] GO:0031953[negative regulation of protein autophosphorylation] GO:0032880[regulation of protein localization] GO:0032956[regulation of actin cytoskeleton organization] GO:0042326[negative regulation of phosphorylation] GO:0042995[cell projection] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051496[positive regulation of stress fiber assembly] GO:0051650[establishment of vesicle localization] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0090521[podocyte cell migration] GO:0106310[protein serine kinase activity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1900182[positive regulation of protein localization to nucleus] GO:1902018[negative regulation of cilium assembly]
The Human Protein Atlas project is funded
