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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q31.3
Chromosome location (bp)
111549722 - 111599893
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) 1. Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha 2. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity) 3. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one 4. May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
NADP
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006691[leukotriene metabolic process] GO:0006693[prostaglandin metabolic process] GO:0016491[oxidoreductase activity] GO:0016628[oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0032440[2-alkenal reductase [NAD(P)+] activity] GO:0035798[2-alkenal reductase (NADP+) activity] GO:0036102[leukotriene B4 metabolic process] GO:0036132[13-prostaglandin reductase activity] GO:0036185[13-lipoxin reductase activity] GO:0047522[15-oxoprostaglandin 13-oxidase activity] GO:0070062[extracellular exosome] GO:0097257[leukotriene B4 12-hydroxy dehydrogenase activity] GO:2001302[lipoxin A4 metabolic process]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006691[leukotriene metabolic process] GO:0006693[prostaglandin metabolic process] GO:0016491[oxidoreductase activity] GO:0016628[oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0032440[2-alkenal reductase [NAD(P)+] activity] GO:0035798[2-alkenal reductase (NADP+) activity] GO:0036102[leukotriene B4 metabolic process] GO:0036132[13-prostaglandin reductase activity] GO:0036185[13-lipoxin reductase activity] GO:0047522[15-oxoprostaglandin 13-oxidase activity] GO:0070062[extracellular exosome] GO:0097257[leukotriene B4 12-hydroxy dehydrogenase activity] GO:0097327[response to antineoplastic agent] GO:2001302[lipoxin A4 metabolic process]
Metabolic proteins MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0006693[prostaglandin metabolic process] GO:0016628[oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0036132[13-prostaglandin reductase activity] GO:0047522[15-oxoprostaglandin 13-oxidase activity]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006691[leukotriene metabolic process] GO:0006693[prostaglandin metabolic process] GO:0016491[oxidoreductase activity] GO:0016628[oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor] GO:0032440[2-alkenal reductase [NAD(P)+] activity] GO:0035798[2-alkenal reductase (NADP+) activity] GO:0036102[leukotriene B4 metabolic process] GO:0036132[13-prostaglandin reductase activity] GO:0036185[13-lipoxin reductase activity] GO:0047522[15-oxoprostaglandin 13-oxidase activity] GO:0070062[extracellular exosome] GO:0097257[leukotriene B4 12-hydroxy dehydrogenase activity] GO:2001302[lipoxin A4 metabolic process]
The Human Protein Atlas project is funded
