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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
p14.1
Chromosome location (bp)
37905932 - 38025695
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation, Wnt signaling pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q6FHJ7 [Direct mapping] Secreted frizzled-related protein 4
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THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002092[positive regulation of receptor internalization] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0008285[negative regulation of cell population proliferation] GO:0009725[response to hormone] GO:0009986[cell surface] GO:0010628[positive regulation of gene expression] GO:0016055[Wnt signaling pathway] GO:0017147[Wnt-protein binding] GO:0030154[cell differentiation] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030510[regulation of BMP signaling pathway] GO:0043065[positive regulation of apoptotic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0045606[positive regulation of epidermal cell differentiation] GO:0048856[anatomical structure development] GO:0050793[regulation of developmental process] GO:0055062[phosphate ion homeostasis] GO:0060070[canonical Wnt signaling pathway] GO:0060349[bone morphogenesis] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:1902174[positive regulation of keratinocyte apoptotic process] GO:2000051[negative regulation of non-canonical Wnt signaling pathway] GO:2000119[negative regulation of sodium-dependent phosphate transport]
C9JMJ2 [Direct mapping] Secreted frizzled-related protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005576[extracellular region] GO:0008285[negative regulation of cell population proliferation] GO:0016055[Wnt signaling pathway] GO:0030154[cell differentiation] GO:0048856[anatomical structure development] GO:0050793[regulation of developmental process] GO:0090090[negative regulation of canonical Wnt signaling pathway]
The Human Protein Atlas project is funded
