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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.2
Chromosome location (bp)
41966582 - 41997497
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Translocase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Metabolic proteins Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the nervous system Nervous system diseases Epilepsy Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000166[nucleotide binding] GO:0001540[amyloid-beta binding] GO:0001917[photoreceptor inner segment] GO:0005215[transporter activity] GO:0005391[P-type sodium:potassium-exchanging transporter activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005890[sodium:potassium-exchanging ATPase complex] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006883[cellular sodium ion homeostasis] GO:0008556[P-type potassium transmembrane transporter activity] GO:0010248[establishment or maintenance of transmembrane electrochemical gradient] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016887[ATP hydrolysis activity] GO:0019829[ATPase-coupled cation transmembrane transporter activity] GO:0030007[cellular potassium ion homeostasis] GO:0030424[axon] GO:0031090[organelle membrane] GO:0032809[neuronal cell body membrane] GO:0034220[ion transmembrane transport] GO:0036376[sodium ion export across plasma membrane] GO:0043025[neuronal cell body] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0051087[chaperone binding] GO:0060075[regulation of resting membrane potential] GO:0060342[photoreceptor inner segment membrane] GO:0071383[cellular response to steroid hormone stimulus] GO:0086064[cell communication by electrical coupling involved in cardiac conduction] GO:0098984[neuron to neuron synapse] GO:1902600[proton transmembrane transport] GO:1903416[response to glycoside] GO:1903561[extracellular vesicle] GO:1904646[cellular response to amyloid-beta] GO:1990239[steroid hormone binding] GO:1990535[neuron projection maintenance] GO:1990573[potassium ion import across plasma membrane]
Enzymes ENZYME proteins Metabolic proteins Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the nervous system Nervous system diseases Epilepsy Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001540[amyloid-beta binding] GO:0001917[photoreceptor inner segment] GO:0005215[transporter activity] GO:0005391[P-type sodium:potassium-exchanging transporter activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005890[sodium:potassium-exchanging ATPase complex] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006883[cellular sodium ion homeostasis] GO:0008556[P-type potassium transmembrane transporter activity] GO:0010248[establishment or maintenance of transmembrane electrochemical gradient] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016887[ATP hydrolysis activity] GO:0019829[ATPase-coupled cation transmembrane transporter activity] GO:0030007[cellular potassium ion homeostasis] GO:0030424[axon] GO:0031090[organelle membrane] GO:0032809[neuronal cell body membrane] GO:0034220[ion transmembrane transport] GO:0036376[sodium ion export across plasma membrane] GO:0043025[neuronal cell body] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0051087[chaperone binding] GO:0060075[regulation of resting membrane potential] GO:0060342[photoreceptor inner segment membrane] GO:0071383[cellular response to steroid hormone stimulus] GO:0086064[cell communication by electrical coupling involved in cardiac conduction] GO:0098984[neuron to neuron synapse] GO:1902600[proton transmembrane transport] GO:1903416[response to glycoside] GO:1903561[extracellular vesicle] GO:1904646[cellular response to amyloid-beta] GO:1990239[steroid hormone binding] GO:1990535[neuron projection maintenance] GO:1990573[potassium ion import across plasma membrane]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Nervous system diseases Epilepsy Other nervous and sensory system diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Metabolic proteins Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the nervous system Nervous system diseases Epilepsy Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000166[nucleotide binding] GO:0001540[amyloid-beta binding] GO:0001917[photoreceptor inner segment] GO:0005215[transporter activity] GO:0005391[P-type sodium:potassium-exchanging transporter activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005886[plasma membrane] GO:0005890[sodium:potassium-exchanging ATPase complex] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006883[cellular sodium ion homeostasis] GO:0008556[P-type potassium transmembrane transporter activity] GO:0010248[establishment or maintenance of transmembrane electrochemical gradient] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016887[ATP hydrolysis activity] GO:0019829[ATPase-coupled cation transmembrane transporter activity] GO:0021987[cerebral cortex development] GO:0030007[cellular potassium ion homeostasis] GO:0030424[axon] GO:0031090[organelle membrane] GO:0031748[D1 dopamine receptor binding] GO:0032809[neuronal cell body membrane] GO:0034220[ion transmembrane transport] GO:0036376[sodium ion export across plasma membrane] GO:0042734[presynaptic membrane] GO:0043025[neuronal cell body] GO:0043209[myelin sheath] GO:0044305[calyx of Held] GO:0044326[dendritic spine neck] GO:0044327[dendritic spine head] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0051087[chaperone binding] GO:0060075[regulation of resting membrane potential] GO:0060342[photoreceptor inner segment membrane] GO:0071300[cellular response to retinoic acid] GO:0071383[cellular response to steroid hormone stimulus] GO:0086064[cell communication by electrical coupling involved in cardiac conduction] GO:0097067[cellular response to thyroid hormone stimulus] GO:0098794[postsynapse] GO:0098984[neuron to neuron synapse] GO:1902600[proton transmembrane transport] GO:1903416[response to glycoside] GO:1903561[extracellular vesicle] GO:1904646[cellular response to amyloid-beta] GO:1990239[steroid hormone binding] GO:1990535[neuron projection maintenance] GO:1990573[potassium ion import across plasma membrane]
The Human Protein Atlas project is funded
