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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.3
Chromosome location (bp)
3506311 - 3538334
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) 1....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Ubl conjugation pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic G2 DNA damage checkpoint signaling; and positive regulation of protein metabolic process. Located in nuclear membrane and nucleoplasm. Colocalizes with anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9UM11 [Direct mapping] Fizzy-related protein homolog
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0007346[regulation of mitotic cell cycle] GO:0010997[anaphase-promoting complex binding] GO:0016567[protein ubiquitination] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0031965[nuclear membrane] GO:0051301[cell division] GO:0051445[regulation of meiotic cell cycle] GO:0070979[protein K11-linked ubiquitination] GO:0097027[ubiquitin-protein transferase activator activity] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1905786[positive regulation of anaphase-promoting complex-dependent catabolic process] GO:1990757[ubiquitin ligase activator activity] GO:2000773[negative regulation of cellular senescence]
Q9UM11 [Direct mapping] Fizzy-related protein homolog
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0007346[regulation of mitotic cell cycle] GO:0010997[anaphase-promoting complex binding] GO:0016567[protein ubiquitination] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0031965[nuclear membrane] GO:0051301[cell division] GO:0051445[regulation of meiotic cell cycle] GO:0070979[protein K11-linked ubiquitination] GO:0097027[ubiquitin-protein transferase activator activity] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1905786[positive regulation of anaphase-promoting complex-dependent catabolic process] GO:1990757[ubiquitin ligase activator activity] GO:2000773[negative regulation of cellular senescence]
Q9UM11 [Direct mapping] Fizzy-related protein homolog
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0007346[regulation of mitotic cell cycle] GO:0008284[positive regulation of cell population proliferation] GO:0010997[anaphase-promoting complex binding] GO:0016567[protein ubiquitination] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0031965[nuclear membrane] GO:0040020[regulation of meiotic nuclear division] GO:0051301[cell division] GO:0051445[regulation of meiotic cell cycle] GO:0051603[proteolysis involved in protein catabolic process] GO:0070306[lens fiber cell differentiation] GO:0070979[protein K11-linked ubiquitination] GO:0097027[ubiquitin-protein transferase activator activity] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1905786[positive regulation of anaphase-promoting complex-dependent catabolic process] GO:1990757[ubiquitin ligase activator activity] GO:2000773[negative regulation of cellular senescence]
Q9UM11 [Direct mapping] Fizzy-related protein homolog
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005680[anaphase-promoting complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006281[DNA repair] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007095[mitotic G2 DNA damage checkpoint signaling] GO:0007346[regulation of mitotic cell cycle] GO:0010997[anaphase-promoting complex binding] GO:0016567[protein ubiquitination] GO:0031145[anaphase-promoting complex-dependent catabolic process] GO:0031965[nuclear membrane] GO:0051301[cell division] GO:0051445[regulation of meiotic cell cycle] GO:0070979[protein K11-linked ubiquitination] GO:0097027[ubiquitin-protein transferase activator activity] GO:1904668[positive regulation of ubiquitin protein ligase activity] GO:1905786[positive regulation of anaphase-promoting complex-dependent catabolic process] GO:1990757[ubiquitin ligase activator activity] GO:2000773[negative regulation of cellular senescence]
The Human Protein Atlas project is funded
