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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.3
Chromosome location (bp)
3610645 - 3626815
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns 1. Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion 2. Involved in the regulation of innate immune response 3. Acts as a negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways 4,5. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli 6,7....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Enables RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of cytokine production; and negative regulation of signal transduction. Located in cytosol and nuclear speck. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000398[mRNA splicing, via spliceosome] GO:0001933[negative regulation of protein phosphorylation] GO:0002376[immune system process] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005681[spliceosomal complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006397[mRNA processing] GO:0008380[RNA splicing] GO:0016607[nuclear speck] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032688[negative regulation of interferon-beta production] GO:0032717[negative regulation of interleukin-8 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034122[negative regulation of toll-like receptor signaling pathway] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0045292[mRNA cis splicing, via spliceosome] GO:0045824[negative regulation of innate immune response] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0071013[catalytic step 2 spliceosome] GO:0071222[cellular response to lipopolysaccharide] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000398[mRNA splicing, via spliceosome] GO:0001933[negative regulation of protein phosphorylation] GO:0002376[immune system process] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005681[spliceosomal complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006397[mRNA processing] GO:0008380[RNA splicing] GO:0016607[nuclear speck] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032688[negative regulation of interferon-beta production] GO:0032717[negative regulation of interleukin-8 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034122[negative regulation of toll-like receptor signaling pathway] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0045292[mRNA cis splicing, via spliceosome] GO:0045824[negative regulation of innate immune response] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0071013[catalytic step 2 spliceosome] GO:0071222[cellular response to lipopolysaccharide] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398[mRNA splicing, via spliceosome] GO:0001933[negative regulation of protein phosphorylation] GO:0002376[immune system process] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005681[spliceosomal complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006397[mRNA processing] GO:0008380[RNA splicing] GO:0016607[nuclear speck] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032688[negative regulation of interferon-beta production] GO:0032717[negative regulation of interleukin-8 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034122[negative regulation of toll-like receptor signaling pathway] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087[innate immune response] GO:0045292[mRNA cis splicing, via spliceosome] GO:0045824[negative regulation of innate immune response] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0071013[catalytic step 2 spliceosome] GO:0071222[cellular response to lipopolysaccharide] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor]