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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
BFAR is not prognostic in Skin Cuteneous Melanoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
3-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
3-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
50.3
Number of samples
99
Samples
Sample
Description
TPM
TCGA-EB-A44O-01A
69 years, male, white, stage:Stage IIB, alive, 81 days
131.0
TCGA-EB-A5FP-01A
65 years, female, white, stage:Stage IV, dead, 454 days
114.7
TCGA-BF-A1PU-01A
46 years, female, white, stage:Stage IIC, alive, 387 days
108.9
TCGA-EB-A431-01A
34 years, male, white, stage:Stage IIC, alive, 568 days
92.4
TCGA-BF-A1PV-01A
74 years, female, white, stage:Stage IIC, alive, 14 days
89.4
TCGA-EB-A5VU-01A
56 years, male, asian, stage:Stage IIIB, dead, 321 days
86.8
TCGA-FW-A5DX-01A
71 years, male, white, stage:Stage IIIC, alive, 640 days
85.5
TCGA-EB-A6R0-01A
58 years, female, white, stage:Stage IIC, dead, 608 days
84.8
TCGA-EB-A6QY-01A
71 years, male, white, stage:Stage IIC, alive, 382 days
84.1
TCGA-BF-AAP4-01A
61 years, male, white, stage:Stage IIC, alive, 335 days
83.1
TCGA-FR-A2OS-01A
49 years, female, white, stage:Stage IIC, dead, 368 days
82.3
TCGA-EB-A1NK-01A
48 years, male, white, stage:Stage IIC, alive, 1039 days
81.8
TCGA-EB-A5SE-01A
73 years, male, white, stage:Stage IIB, dead, 401 days
80.9
TCGA-EB-A24C-01A
56 years, male, white, stage:'--, alive, 632 days
79.7
TCGA-EB-A24D-01A
72 years, male, white, stage:Stage IIIB, alive, 645 days
76.2
TCGA-ER-A19K-01A
79 years, female, white, stage:Stage IIC, dead, 469 days
76.1
TCGA-ER-A2NF-01A
53 years, male, white, stage:Stage IIIB, dead, 877 days
74.4
TCGA-BF-A5ER-01A
63 years, male, white, stage:Stage IIC, alive, 327 days
73.9
TCGA-BF-A5EP-01A
75 years, female, white, stage:Stage IIIC, alive, 335 days
70.0
TCGA-BF-A3DM-01A
63 years, male, white, stage:Stage IIA, alive, 601 days
69.7
TCGA-FR-A3R1-01A
69 years, male, white, stage:Stage IIC, alive, 685 days
68.6
TCGA-EB-A82C-01A
70 years, female, asian, stage:Stage IIC, alive, 17 days
68.5
TCGA-GN-A263-01A
24 years, male, white, stage:Stage IV, dead, 467 days
68.4
TCGA-WE-A8K4-01A
85 years, male, white, stage:Stage IIB, alive, 614 days
66.6
TCGA-BF-AAP1-01A
86 years, male, white, stage:Stage IIC, alive, 409 days
65.8
TCGA-EB-A3Y6-01A
56 years, female, white, stage:Stage IIC, alive, 126 days
64.9
TCGA-BF-A9VF-01A
77 years, male, white, stage:Stage IIC, alive, 440 days
64.7
TCGA-XV-A9W5-01A
51 years, male, white, stage:Not Reported, alive, 392 days
63.1
TCGA-EB-A3XB-01A
63 years, male, white, stage:Stage II, alive, 796 days
62.4
TCGA-BF-A1PZ-01A
71 years, female, white, stage:Stage IIB, alive, 853 days
61.4
TCGA-BF-A3DN-01A
81 years, female, white, stage:Stage IIIC, alive, 717 days
59.8
TCGA-D9-A4Z5-01A
68 years, male, white, stage:Stage IIB, alive, 218 days
58.7
TCGA-EB-A42Z-01A
49 years, male, asian, stage:Stage IIIC, alive, 441 days
58.2
TCGA-BF-A5EQ-01A
63 years, male, white, stage:Stage IIC, alive, 323 days
56.7
TCGA-GF-A769-01A
39 years, male, white, stage:Stage IIC, dead, 1070 days
56.6
TCGA-BF-AAP2-01A
62 years, male, white, stage:Stage IIB, alive, 405 days
56.3
TCGA-D9-A4Z2-01A
50 years, male, white, stage:Stage IIIC, dead, 190 days
55.5
TCGA-GF-A2C7-01A
48 years, male, white, stage:Stage IIC, alive, 21 days
54.2
TCGA-BF-AAP6-01A
55 years, male, white, stage:Stage III, alive, 325 days
54.2
TCGA-EB-A3XF-01A
57 years, male, white, stage:Stage IIC, alive, 278 days
54.0
TCGA-EB-A4P0-01A
82 years, male, white, stage:Stage IIC, dead, 326 days
52.9
TCGA-BF-AAOX-01A
83 years, male, white, stage:Stage IIC, alive, 444 days
51.3
TCGA-GN-A8LN-01A
68 years, male, white, stage:Stage IIC, alive, 772 days
50.9
TCGA-ER-A196-01A
64 years, female, white, stage:Stage IIC, alive, 1785 days
49.5
TCGA-BF-A3DL-01A
84 years, female, white, stage:Stage IIIB, alive, 769 days
49.1
TCGA-EB-A42Y-01A
73 years, female, asian, stage:Stage IIC, dead, 721 days
48.6
TCGA-EB-A44N-01A
59 years, male, white, stage:Stage IIC, dead, 205 days
48.4
TCGA-EB-A51B-01A
53 years, male, white, stage:Stage IIC, alive, 931 days
47.9
TCGA-D9-A3Z4-01A
54 years, male, white, stage:Stage IIIC, dead, 519 days
47.9
TCGA-ER-A194-01A
77 years, male, white, stage:'--, dead, 1354 days
47.6
TCGA-EB-A57M-01A
56 years, male, asian, stage:Stage IIIB, dead, 472 days
47.2
TCGA-BF-A1Q0-01A
80 years, male, white, stage:Stage IIC, alive, 831 days
46.8
TCGA-EB-A3XC-01A
74 years, male, white, stage:Stage IIC, alive, 650 days
45.8
TCGA-BF-A5ES-01A
76 years, female, white, stage:Stage IIC, alive, 490 days
44.2
TCGA-IH-A3EA-01A
61 years, male, white, stage:Stage IIC, alive, 524 days
44.2
TCGA-EB-A4XL-01A
56 years, female, white, stage:Stage IIC, alive, 777 days
43.9
TCGA-EB-A6QZ-01A
76 years, female, white, stage:Stage IIA, dead, 352 days
42.3
TCGA-EB-A44P-01A
58 years, female, white, stage:Stage IIC, alive, 741 days
42.1
TCGA-EB-A4IQ-01A
42 years, female, asian, stage:Stage IIIB, dead, 636 days
41.6
TCGA-EB-A3XE-01A
77 years, female, white, stage:Stage IIA, alive, 180 days
41.1
TCGA-FS-A1ZN-01A
43 years, male, white, stage:Stage IIIA, dead, 730 days
40.6
TCGA-BF-AAP7-01A
76 years, female, white, stage:Stage IIC, alive, 318 days
38.7
TCGA-BF-A5EO-01A
65 years, male, white, stage:Stage IIC, alive, 703 days
38.1
TCGA-EB-A5UM-01A
48 years, female, white, stage:Stage IIC, alive, 779 days
38.0
TCGA-XV-AAZY-01A
76 years, female, white, stage:Stage IIIC, alive, 405 days
37.8
TCGA-EB-A41B-01A
76 years, female, white, stage:Stage IIC, alive, 291 days
37.1
TCGA-EB-A4IS-01A
77 years, male, white, stage:Stage IIB, alive, 774 days
37.0
TCGA-YG-AA3N-01A
67 years, male, stage:Stage IIC, alive, 306 days
36.3
TCGA-ER-A42H-01A
76 years, male, white, stage:'--, dead, 426 days
36.2
TCGA-EB-A82B-01A
58 years, female, asian, stage:Stage III, alive, 390 days
35.2
TCGA-EB-A85J-01A
66 years, female, white, stage:Stage IIB, alive, 360 days
34.7
TCGA-EB-A551-01A
78 years, female, white, stage:Stage IIIC, alive, 590 days
33.9
TCGA-XV-AAZV-01A
56 years, female, white, stage:Stage II, alive, 412 days
32.7
TCGA-BF-AAP8-01A
58 years, male, white, stage:Stage IIC, alive, 447 days
32.3
TCGA-FR-A728-01A
54 years, female, white, stage:Stage IIIB, alive, 583 days
32.0
TCGA-D9-A4Z3-01A
73 years, female, white, stage:Stage IIIC, alive, 505 days
30.7
TCGA-EB-A5SF-01A
78 years, female, white, stage:Stage IIC, dead, 369 days
30.4
TCGA-ER-A19T-01A
51 years, male, white, stage:Stage IV, dead, 270 days
30.4
TCGA-BF-A3DJ-01A
36 years, female, white, stage:Stage IIIB, alive, 464 days
30.1
TCGA-GN-A4U5-01A
61 years, female, white, stage:Stage IB, alive, 1156 days
27.9
TCGA-EB-A3XD-01A
53 years, female, white, stage:Stage IIC, alive, 1160 days
27.4
TCGA-EB-A3Y7-01A
86 years, female, white, stage:Stage IIIB, dead, 326 days
27.3
TCGA-EB-A97M-01A
66 years, male, white, stage:Stage IIC, alive, 414 days
26.4
TCGA-XV-AAZW-01A
62 years, female, white, stage:Stage II, dead, 393 days
26.1
TCGA-GN-A26C-01A
77 years, male, white, stage:Stage IIIC, dead, 821 days
24.7
TCGA-BF-AAOU-01A
73 years, female, white, stage:Stage IIC, alive, 476 days
23.7
TCGA-EB-A553-01A
62 years, male, white, stage:Stage IIC, alive, 226 days
23.5
TCGA-BF-A1PX-01A
56 years, male, white, stage:Stage IIIB, dead, 282 days
22.9
TCGA-D3-A5GT-01A
43 years, male, white, stage:Stage IIIC, alive, 487 days
21.0
TCGA-EB-A85I-01A
66 years, male, white, stage:Stage IIC, alive, 362 days
20.4
TCGA-DA-A960-01A
73 years, male, white, stage:Stage IIB, alive, 804 days
20.4
TCGA-EB-A550-01A
75 years, female, white, stage:Stage IIC, dead, 264 days
20.3
TCGA-EB-A3HV-01A
37 years, male, white, stage:Stage IIC, alive, 39 days
18.7
TCGA-XV-A9W2-01A
81 years, male, white, stage:Stage I, alive, 417 days
17.2
TCGA-EB-A299-01A
63 years, male, white, stage:Stage IIA, alive, 378 days
14.3
TCGA-EB-A4OY-01A
65 years, female, white, stage:Stage IIIB, alive, 977 days
12.6
TCGA-ER-A2NB-01A
57 years, male, white, stage:Stage IIIB, dead, 857 days
11.4
TCGA-EB-A4OZ-01A
41 years, female, white, stage:Stage IIIC, alive, 620 days
9.0
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MELANOMA - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
The Human Protein Atlas project is funded
