We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q22.1
Chromosome location (bp)
67154185 - 67159909
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD 1,2,3. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B 4,5. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q15628 [Direct mapping] Tumor necrosis factor receptor type 1-associated DEATH domain protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002947[tumor necrosis factor receptor superfamily complex] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005164[tumor necrosis factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0019900[kinase binding] GO:0030335[positive regulation of cell migration] GO:0031264[death-inducing signaling complex] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0042802[identical protein binding] GO:0043065[positive regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235[receptor complex] GO:0044877[protein-containing complex binding] GO:0045121[membrane raft] GO:0050729[positive regulation of inflammatory response] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051798[positive regulation of hair follicle development] GO:0060090[molecular adaptor activity] GO:0070513[death domain binding] GO:0071356[cellular response to tumor necrosis factor] GO:0097191[extrinsic apoptotic signaling pathway] GO:1901224[positive regulation of NIK/NF-kappaB signaling]
Q15628 [Direct mapping] Tumor necrosis factor receptor type 1-associated DEATH domain protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002947[tumor necrosis factor receptor superfamily complex] GO:0005068[transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0019900[kinase binding] GO:0030335[positive regulation of cell migration] GO:0031264[death-inducing signaling complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0042802[identical protein binding] GO:0043065[positive regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235[receptor complex] GO:0050729[positive regulation of inflammatory response] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060090[molecular adaptor activity] GO:0070513[death domain binding] GO:0071356[cellular response to tumor necrosis factor] GO:0097191[extrinsic apoptotic signaling pathway] GO:1901224[positive regulation of NIK/NF-kappaB signaling]
The Human Protein Atlas project is funded
