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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q12.11
Chromosome location (bp)
21671073 - 21704498
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
THUMBUP predicted membrane proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001525[angiogenesis] GO:0001649[osteoblast differentiation] GO:0001654[eye development] GO:0001934[positive regulation of protein phosphorylation] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0002062[chondrocyte differentiation] GO:0005104[fibroblast growth factor receptor binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0006606[protein import into nucleus] GO:0007165[signal transduction] GO:0007224[smoothened signaling pathway] GO:0007267[cell-cell signaling] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0008584[male gonad development] GO:0009887[animal organ morphogenesis] GO:0010463[mesenchymal cell proliferation] GO:0010628[positive regulation of gene expression] GO:0016055[Wnt signaling pathway] GO:0021762[substantia nigra development] GO:0030154[cell differentiation] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030238[male sex determination] GO:0030324[lung development] GO:0030326[embryonic limb morphogenesis] GO:0030334[regulation of cell migration] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032924[activin receptor signaling pathway] GO:0032927[positive regulation of activin receptor signaling pathway] GO:0042472[inner ear morphogenesis] GO:0045880[positive regulation of smoothened signaling pathway] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0048505[regulation of timing of cell differentiation] GO:0048566[embryonic digestive tract development] GO:0048706[embryonic skeletal system development] GO:0050673[epithelial cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060011[Sertoli cell proliferation] GO:0060038[cardiac muscle cell proliferation] GO:0060045[positive regulation of cardiac muscle cell proliferation] GO:0060070[canonical Wnt signaling pathway] GO:0060484[lung-associated mesenchyme development] GO:0072089[stem cell proliferation] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1904754[positive regulation of vascular associated smooth muscle cell migration] GO:1905931[negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching] GO:2000243[positive regulation of reproductive process] GO:2000648[positive regulation of stem cell proliferation]
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