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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
q21.1
Chromosome location (bp)
48919853 - 48950965
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access 1. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O15105 [Direct mapping] Mothers against decapentaplegic homolog 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Disease related genes Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0001650[fibrillar center] GO:0001657[ureteric bud development] GO:0002725[negative regulation of T cell cytokine production] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0006355[regulation of DNA-templated transcription] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0008013[beta-catenin binding] GO:0009653[anatomical structure morphogenesis] GO:0010717[regulation of epithelial to mesenchymal transition] GO:0010719[negative regulation of epithelial to mesenchymal transition] GO:0010801[negative regulation of peptidyl-threonine phosphorylation] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0017015[regulation of transforming growth factor beta receptor signaling pathway] GO:0022409[positive regulation of cell-cell adhesion] GO:0030154[cell differentiation] GO:0030279[negative regulation of ossification] GO:0030336[negative regulation of cell migration] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030514[negative regulation of BMP signaling pathway] GO:0031397[negative regulation of protein ubiquitination] GO:0031398[positive regulation of protein ubiquitination] GO:0031503[protein-containing complex localization] GO:0031625[ubiquitin protein ligase binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032925[regulation of activin receptor signaling pathway] GO:0032991[protein-containing complex] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0034333[adherens junction assembly] GO:0034616[response to laminar fluid shear stress] GO:0034713[type I transforming growth factor beta receptor binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0046872[metal ion binding] GO:0048185[activin binding] GO:0048844[artery morphogenesis] GO:0050821[protein stabilization] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0055010[ventricular cardiac muscle tissue morphogenesis] GO:0055117[regulation of cardiac muscle contraction] GO:0060373[regulation of ventricular cardiac muscle cell membrane depolarization] GO:0060389[pathway-restricted SMAD protein phosphorylation] GO:0060394[negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395[SMAD protein signal transduction] GO:0060412[ventricular septum morphogenesis] GO:0070411[I-SMAD binding] GO:0071144[heteromeric SMAD protein complex] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140416[transcription regulator inhibitor activity] GO:1902731[negative regulation of chondrocyte proliferation] GO:1903043[positive regulation of chondrocyte hypertrophy] GO:1990830[cellular response to leukemia inhibitory factor] GO:2000317[negative regulation of T-helper 17 type immune response] GO:2000320[negative regulation of T-helper 17 cell differentiation]
O15105 [Direct mapping] Mothers against decapentaplegic homolog 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Disease related genes Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0001650[fibrillar center] GO:0002725[negative regulation of T cell cytokine production] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0006355[regulation of DNA-templated transcription] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0008013[beta-catenin binding] GO:0009653[anatomical structure morphogenesis] GO:0010717[regulation of epithelial to mesenchymal transition] GO:0010719[negative regulation of epithelial to mesenchymal transition] GO:0010801[negative regulation of peptidyl-threonine phosphorylation] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0017015[regulation of transforming growth factor beta receptor signaling pathway] GO:0022409[positive regulation of cell-cell adhesion] GO:0030154[cell differentiation] GO:0030336[negative regulation of cell migration] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030514[negative regulation of BMP signaling pathway] GO:0031397[negative regulation of protein ubiquitination] GO:0031398[positive regulation of protein ubiquitination] GO:0031503[protein-containing complex localization] GO:0031625[ubiquitin protein ligase binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032925[regulation of activin receptor signaling pathway] GO:0032991[protein-containing complex] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0034333[adherens junction assembly] GO:0034616[response to laminar fluid shear stress] GO:0034713[type I transforming growth factor beta receptor binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0046872[metal ion binding] GO:0048185[activin binding] GO:0048844[artery morphogenesis] GO:0050821[protein stabilization] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0055010[ventricular cardiac muscle tissue morphogenesis] GO:0055117[regulation of cardiac muscle contraction] GO:0060373[regulation of ventricular cardiac muscle cell membrane depolarization] GO:0060389[pathway-restricted SMAD protein phosphorylation] GO:0060394[negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395[SMAD protein signal transduction] GO:0060412[ventricular septum morphogenesis] GO:0070411[I-SMAD binding] GO:0071144[heteromeric SMAD protein complex] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140416[transcription regulator inhibitor activity] GO:2000317[negative regulation of T-helper 17 type immune response] GO:2000320[negative regulation of T-helper 17 cell differentiation]
O15105 [Direct mapping] Mothers against decapentaplegic homolog 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Disease related genes Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0001650[fibrillar center] GO:0002725[negative regulation of T cell cytokine production] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0006355[regulation of DNA-templated transcription] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0008013[beta-catenin binding] GO:0009653[anatomical structure morphogenesis] GO:0010717[regulation of epithelial to mesenchymal transition] GO:0010719[negative regulation of epithelial to mesenchymal transition] GO:0010801[negative regulation of peptidyl-threonine phosphorylation] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0017015[regulation of transforming growth factor beta receptor signaling pathway] GO:0022409[positive regulation of cell-cell adhesion] GO:0030154[cell differentiation] GO:0030336[negative regulation of cell migration] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030514[negative regulation of BMP signaling pathway] GO:0031397[negative regulation of protein ubiquitination] GO:0031398[positive regulation of protein ubiquitination] GO:0031503[protein-containing complex localization] GO:0031625[ubiquitin protein ligase binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032925[regulation of activin receptor signaling pathway] GO:0032991[protein-containing complex] GO:0033137[negative regulation of peptidyl-serine phosphorylation] GO:0034333[adherens junction assembly] GO:0034616[response to laminar fluid shear stress] GO:0034713[type I transforming growth factor beta receptor binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0046872[metal ion binding] GO:0048185[activin binding] GO:0048844[artery morphogenesis] GO:0050821[protein stabilization] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0055010[ventricular cardiac muscle tissue morphogenesis] GO:0055117[regulation of cardiac muscle contraction] GO:0060373[regulation of ventricular cardiac muscle cell membrane depolarization] GO:0060389[pathway-restricted SMAD protein phosphorylation] GO:0060394[negative regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395[SMAD protein signal transduction] GO:0060412[ventricular septum morphogenesis] GO:0070411[I-SMAD binding] GO:0071144[heteromeric SMAD protein complex] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0140416[transcription regulator inhibitor activity] GO:2000317[negative regulation of T-helper 17 type immune response] GO:2000320[negative regulation of T-helper 17 cell differentiation]