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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
p11.32
Chromosome location (bp)
158383 - 214629
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins 1. Ensures the regeneration of ubiquitin at the proteasome 2,3. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell 4. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis 5. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 6. Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation 7. Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protease, Thiol protease
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000502[proteasome complex] GO:0002376[immune system process] GO:0004197[cysteine-type endopeptidase activity] GO:0004843[cysteine-type deubiquitinase activity] GO:0004866[endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006508[proteolysis] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0007268[chemical synaptic transmission] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0009986[cell surface] GO:0016020[membrane] GO:0016579[protein deubiquitination] GO:0016787[hydrolase activity] GO:0031410[cytoplasmic vesicle] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087[innate immune response] GO:0045202[synapse] GO:0050920[regulation of chemotaxis] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0061136[regulation of proteasomal protein catabolic process] GO:0061578[Lys63-specific deubiquitinase activity] GO:0070062[extracellular exosome] GO:0070628[proteasome binding] GO:1903070[negative regulation of ER-associated ubiquitin-dependent protein catabolic process]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502[proteasome complex] GO:0002376[immune system process] GO:0004197[cysteine-type endopeptidase activity] GO:0004843[cysteine-type deubiquitinase activity] GO:0004866[endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006508[proteolysis] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0009986[cell surface] GO:0016020[membrane] GO:0016579[protein deubiquitination] GO:0016787[hydrolase activity] GO:0031410[cytoplasmic vesicle] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087[innate immune response] GO:0050920[regulation of chemotaxis] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0061136[regulation of proteasomal protein catabolic process] GO:0061578[Lys63-specific deubiquitinase activity] GO:0070062[extracellular exosome] GO:0070628[proteasome binding] GO:1903070[negative regulation of ER-associated ubiquitin-dependent protein catabolic process]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502[proteasome complex] GO:0002376[immune system process] GO:0004197[cysteine-type endopeptidase activity] GO:0004843[cysteine-type deubiquitinase activity] GO:0004866[endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006508[proteolysis] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008233[peptidase activity] GO:0008234[cysteine-type peptidase activity] GO:0009986[cell surface] GO:0016020[membrane] GO:0016579[protein deubiquitination] GO:0016787[hydrolase activity] GO:0031410[cytoplasmic vesicle] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087[innate immune response] GO:0050920[regulation of chemotaxis] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0061136[regulation of proteasomal protein catabolic process] GO:0061578[Lys63-specific deubiquitinase activity] GO:0070062[extracellular exosome] GO:0070628[proteasome binding] GO:1903070[negative regulation of ER-associated ubiquitin-dependent protein catabolic process]
The Human Protein Atlas project is funded
