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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q11.21
Chromosome location (bp)
32052197 - 32101856
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Kinase, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001784[phosphotyrosine residue binding] GO:0002376[immune system process] GO:0002522[leukocyte migration involved in immune response] GO:0002758[innate immune response-activating signal transduction] GO:0002862[negative regulation of inflammatory response to antigenic stimulus] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0006887[exocytosis] GO:0006909[phagocytosis] GO:0006954[inflammatory response] GO:0007155[cell adhesion] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0007498[mesoderm development] GO:0008284[positive regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0030133[transport vesicle] GO:0030154[cell differentiation] GO:0030838[positive regulation of actin filament polymerization] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031410[cytoplasmic vesicle] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043299[leukocyte degranulation] GO:0045087[innate immune response] GO:0045728[respiratory burst after phagocytosis] GO:0046777[protein autophosphorylation] GO:0050727[regulation of inflammatory response] GO:0050764[regulation of phagocytosis] GO:0051090[regulation of DNA-binding transcription factor activity] GO:0051179[localization] GO:0060333[type II interferon-mediated signaling pathway] GO:0070161[anchoring junction] GO:0071801[regulation of podosome assembly] GO:2000251[positive regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001784[phosphotyrosine residue binding] GO:0002376[immune system process] GO:0002522[leukocyte migration involved in immune response] GO:0002758[innate immune response-activating signal transduction] GO:0002862[negative regulation of inflammatory response to antigenic stimulus] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0006887[exocytosis] GO:0006909[phagocytosis] GO:0006954[inflammatory response] GO:0007155[cell adhesion] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0007498[mesoderm development] GO:0008284[positive regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0030133[transport vesicle] GO:0030154[cell differentiation] GO:0030838[positive regulation of actin filament polymerization] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031410[cytoplasmic vesicle] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043299[leukocyte degranulation] GO:0045087[innate immune response] GO:0045728[respiratory burst after phagocytosis] GO:0046777[protein autophosphorylation] GO:0050727[regulation of inflammatory response] GO:0050764[regulation of phagocytosis] GO:0051090[regulation of DNA-binding transcription factor activity] GO:0051179[localization] GO:0060333[type II interferon-mediated signaling pathway] GO:0070161[anchoring junction] GO:0071801[regulation of podosome assembly] GO:2000251[positive regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001784[phosphotyrosine residue binding] GO:0002376[immune system process] GO:0002522[leukocyte migration involved in immune response] GO:0002758[innate immune response-activating signal transduction] GO:0002862[negative regulation of inflammatory response to antigenic stimulus] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0006887[exocytosis] GO:0006909[phagocytosis] GO:0006954[inflammatory response] GO:0007155[cell adhesion] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0007498[mesoderm development] GO:0008284[positive regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0030133[transport vesicle] GO:0030154[cell differentiation] GO:0030838[positive regulation of actin filament polymerization] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031410[cytoplasmic vesicle] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043299[leukocyte degranulation] GO:0045087[innate immune response] GO:0045728[respiratory burst after phagocytosis] GO:0046777[protein autophosphorylation] GO:0050727[regulation of inflammatory response] GO:0050764[regulation of phagocytosis] GO:0051090[regulation of DNA-binding transcription factor activity] GO:0051179[localization] GO:0060333[type II interferon-mediated signaling pathway] GO:0070161[anchoring junction] GO:0071801[regulation of podosome assembly] GO:2000251[positive regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001784[phosphotyrosine residue binding] GO:0002376[immune system process] GO:0002522[leukocyte migration involved in immune response] GO:0002758[innate immune response-activating signal transduction] GO:0002862[negative regulation of inflammatory response to antigenic stimulus] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0006887[exocytosis] GO:0006909[phagocytosis] GO:0006954[inflammatory response] GO:0007155[cell adhesion] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0007498[mesoderm development] GO:0008284[positive regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0030133[transport vesicle] GO:0030154[cell differentiation] GO:0030838[positive regulation of actin filament polymerization] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031410[cytoplasmic vesicle] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043299[leukocyte degranulation] GO:0045087[innate immune response] GO:0045728[respiratory burst after phagocytosis] GO:0046777[protein autophosphorylation] GO:0050727[regulation of inflammatory response] GO:0050764[regulation of phagocytosis] GO:0051090[regulation of DNA-binding transcription factor activity] GO:0051179[localization] GO:0060333[type II interferon-mediated signaling pathway] GO:0070161[anchoring junction] GO:0071801[regulation of podosome assembly] GO:2000251[positive regulation of actin cytoskeleton reorganization]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001784[phosphotyrosine residue binding] GO:0002376[immune system process] GO:0002522[leukocyte migration involved in immune response] GO:0002758[innate immune response-activating signal transduction] GO:0002862[negative regulation of inflammatory response to antigenic stimulus] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004715[non-membrane spanning protein tyrosine kinase activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005884[actin filament] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0006887[exocytosis] GO:0006909[phagocytosis] GO:0006954[inflammatory response] GO:0007155[cell adhesion] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0007498[mesoderm development] GO:0008284[positive regulation of cell population proliferation] GO:0008289[lipid binding] GO:0008360[regulation of cell shape] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0030133[transport vesicle] GO:0030154[cell differentiation] GO:0030838[positive regulation of actin filament polymerization] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031410[cytoplasmic vesicle] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042995[cell projection] GO:0043066[negative regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043299[leukocyte degranulation] GO:0045087[innate immune response] GO:0045728[respiratory burst after phagocytosis] GO:0046777[protein autophosphorylation] GO:0050727[regulation of inflammatory response] GO:0050764[regulation of phagocytosis] GO:0051090[regulation of DNA-binding transcription factor activity] GO:0051179[localization] GO:0060333[type II interferon-mediated signaling pathway] GO:0070161[anchoring junction] GO:0071801[regulation of podosome assembly] GO:2000251[positive regulation of actin cytoskeleton reorganization]