We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.2
Chromosome location (bp)
51386957 - 51562831
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF 1. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway 2. Is involved in the negative regulation of chondrogenesis 3. Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13469 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0009410[response to xenobiotic stimulus] GO:0010628[positive regulation of gene expression] GO:0014904[myotube cell development] GO:0016477[cell migration] GO:0019902[phosphatase binding] GO:0030890[positive regulation of B cell proliferation] GO:0033173[calcineurin-NFAT signaling cascade] GO:0035976[transcription factor AP-1 complex] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050853[B cell receptor signaling pathway] GO:0060090[molecular adaptor activity] GO:0071889[14-3-3 protein binding] GO:0098781[ncRNA transcription] GO:1901741[positive regulation of myoblast fusion] GO:1905064[negative regulation of vascular associated smooth muscle cell differentiation] GO:1990837[sequence-specific double-stranded DNA binding] GO:1990904[ribonucleoprotein complex]
Q13469 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0009410[response to xenobiotic stimulus] GO:0016477[cell migration] GO:0019902[phosphatase binding] GO:0030890[positive regulation of B cell proliferation] GO:0033173[calcineurin-NFAT signaling cascade] GO:0035976[transcription factor AP-1 complex] GO:0045893[positive regulation of DNA-templated transcription] GO:0050853[B cell receptor signaling pathway] GO:0060090[molecular adaptor activity] GO:0071889[14-3-3 protein binding] GO:1905064[negative regulation of vascular associated smooth muscle cell differentiation] GO:1990837[sequence-specific double-stranded DNA binding]
Q13469 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0009410[response to xenobiotic stimulus] GO:0016477[cell migration] GO:0019902[phosphatase binding] GO:0030890[positive regulation of B cell proliferation] GO:0033173[calcineurin-NFAT signaling cascade] GO:0035976[transcription factor AP-1 complex] GO:0045893[positive regulation of DNA-templated transcription] GO:0050853[B cell receptor signaling pathway] GO:0060090[molecular adaptor activity] GO:0071889[14-3-3 protein binding] GO:1905064[negative regulation of vascular associated smooth muscle cell differentiation] GO:1990837[sequence-specific double-stranded DNA binding]
Q13469 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0009410[response to xenobiotic stimulus] GO:0016477[cell migration] GO:0019902[phosphatase binding] GO:0030890[positive regulation of B cell proliferation] GO:0033173[calcineurin-NFAT signaling cascade] GO:0035976[transcription factor AP-1 complex] GO:0045893[positive regulation of DNA-templated transcription] GO:0050853[B cell receptor signaling pathway] GO:0060090[molecular adaptor activity] GO:0071889[14-3-3 protein binding] GO:1905064[negative regulation of vascular associated smooth muscle cell differentiation] GO:1990837[sequence-specific double-stranded DNA binding]
Q13469 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0009410[response to xenobiotic stimulus] GO:0016477[cell migration] GO:0019902[phosphatase binding] GO:0030890[positive regulation of B cell proliferation] GO:0033173[calcineurin-NFAT signaling cascade] GO:0035976[transcription factor AP-1 complex] GO:0045893[positive regulation of DNA-templated transcription] GO:0050853[B cell receptor signaling pathway] GO:0060090[molecular adaptor activity] GO:0071889[14-3-3 protein binding] GO:1905064[negative regulation of vascular associated smooth muscle cell differentiation] GO:1990837[sequence-specific double-stranded DNA binding]
Q13469 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006974[cellular response to DNA damage stimulus] GO:0009410[response to xenobiotic stimulus] GO:0016477[cell migration] GO:0019902[phosphatase binding] GO:0030890[positive regulation of B cell proliferation] GO:0033173[calcineurin-NFAT signaling cascade] GO:0035976[transcription factor AP-1 complex] GO:0045893[positive regulation of DNA-templated transcription] GO:0050853[B cell receptor signaling pathway] GO:0060090[molecular adaptor activity] GO:0071889[14-3-3 protein binding] GO:1905064[negative regulation of vascular associated smooth muscle cell differentiation] GO:1990837[sequence-specific double-stranded DNA binding]
The Human Protein Atlas project is funded
