Cell line - SLC7A4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC7A4
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 7 member 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression based on cell line data from the DepMap portal and cell line data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Testis cancer - Unknown function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cancer enhanced (Skin cancer)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.85
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

CELL LINE GROUPSⁱ

Cell line categories

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Expression

RNA specificity: Cancer enhanced (Skin cancer)

RNAⁱ

Proteinⁱ

COMMON CELL LINESⁱ

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Expression

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EXPRESSION CLUSTERING & CORRELATIONⁱ

SLC7A4 is part of cluster 34 Testis cancer - Unknown function with confidenceⁱ 1
159 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HTRA4	HtrA serine peptidase 4	0.8950	34
GPR32	G protein-coupled receptor 32	0.8947	34
ACTA1	Actin alpha 1, skeletal muscle	0.8906	34
TEX37	Testis expressed 37	0.8891	34
ISM2	Isthmin 2	0.8857	34
DPPA3	Developmental pluripotency associated 3	0.8850	34
MYOZ1	Myozenin 1	0.8762	34
GH2	Growth hormone 2	0.8679	34
GCM1	Glial cells missing transcription factor 1	0.8614	34
LYZL6	Lysozyme like 6	0.8557	34
ENSG00000236543	Novel beta-lactoglobulin-like protein	0.8420	34
DNMT3L	DNA methyltransferase 3 like	0.8274	34
TRIM60	Tripartite motif containing 60	0.8243	34
TRIM75	Tripartite motif containing 75	0.7809	34
ERVV-2	Endogenous retrovirus group V member 2, envelope	0.7582	34

CELL LINE DATA

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Expression

Adrenocortical cancer (n=1)

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Bile duct cancer (n=7)

RNAⁱ

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Bladder cancer (n=26)

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Bone cancer (n=21)

RNAⁱ

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Brain cancer (n=80)

RNAⁱ

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Expression

Breast cancer (n=62)

RNAⁱ

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Cervical cancer (n=8)

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Colorectal cancer (n=63)

RNAⁱ

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Esophageal cancer (n=27)

RNAⁱ

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Expression

Gallbladder cancer (n=1)

RNAⁱ

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Gastric cancer (n=42)

RNAⁱ

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Head and Neck cancer (n=38)

RNAⁱ

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Kidney cancer (n=35)

RNAⁱ

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Leukemia (n=93)

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Liver cancer (n=24)

RNAⁱ

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Lung cancer (n=232)

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Lymphoma (n=76)

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Myeloma (n=34)

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Neuroblastoma (n=17)

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Non-cancerous (n=63)

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Ovarian cancer (n=59)

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Pancreatic cancer (n=46)

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Prostate cancer (n=8)

RNAⁱ

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Rhabdoid (n=14)

RNAⁱ

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Sarcoma (n=15)

RNAⁱ

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Skin cancer (n=62)

RNAⁱ

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Testis cancer (n=1)

RNAⁱ

Proteinⁱ

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Thyroid cancer (n=11)

RNAⁱ

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Uncategorized (n=11)

RNAⁱ

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Uterine cancer (n=29)

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