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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
p22.3
Chromosome location (bp)
32224453 - 32265732
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis 1. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9NPP4 [Direct mapping] NLR family CARD domain-containing protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0002218[activation of innate immune response] GO:0002221[pattern recognition receptor signaling pathway] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0010954[positive regulation of protein processing] GO:0016045[detection of bacterium] GO:0031347[regulation of defense response] GO:0032731[positive regulation of interleukin-1 beta production] GO:0042742[defense response to bacterium] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0045087[innate immune response] GO:0046456[icosanoid biosynthetic process] GO:0050729[positive regulation of inflammatory response] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051260[protein homooligomerization] GO:0061133[endopeptidase activator activity] GO:0061702[inflammasome complex] GO:0070269[pyroptosis] GO:0072557[IPAF inflammasome complex] GO:0089720[caspase binding] GO:0097202[activation of cysteine-type endopeptidase activity]
Q9NPP4 [Direct mapping] NLR family CARD domain-containing protein 4
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0002218[activation of innate immune response] GO:0002221[pattern recognition receptor signaling pathway] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0010954[positive regulation of protein processing] GO:0016045[detection of bacterium] GO:0031347[regulation of defense response] GO:0032731[positive regulation of interleukin-1 beta production] GO:0042742[defense response to bacterium] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0045087[innate immune response] GO:0046456[icosanoid biosynthetic process] GO:0050729[positive regulation of inflammatory response] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051260[protein homooligomerization] GO:0061133[endopeptidase activator activity] GO:0061702[inflammasome complex] GO:0070269[pyroptosis] GO:0072557[IPAF inflammasome complex] GO:0089720[caspase binding] GO:0097202[activation of cysteine-type endopeptidase activity]
Q9NPP4 [Direct mapping] NLR family CARD domain-containing protein 4
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0002218[activation of innate immune response] GO:0002221[pattern recognition receptor signaling pathway] GO:0002376[immune system process] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0010954[positive regulation of protein processing] GO:0016045[detection of bacterium] GO:0031347[regulation of defense response] GO:0032731[positive regulation of interleukin-1 beta production] GO:0042742[defense response to bacterium] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0045087[innate immune response] GO:0046456[icosanoid biosynthetic process] GO:0050729[positive regulation of inflammatory response] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051260[protein homooligomerization] GO:0061133[endopeptidase activator activity] GO:0061702[inflammasome complex] GO:0070269[pyroptosis] GO:0072557[IPAF inflammasome complex] GO:0089720[caspase binding] GO:0097202[activation of cysteine-type endopeptidase activity]
A0A494BZZ1 [Direct mapping] NLR family CARD domain-containing protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases
The Human Protein Atlas project is funded
