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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.2
Chromosome location (bp)
67583742 - 67586656
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) 1. Participates in the formation of novel hepoxilin regioisomers 2. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid metabolism
Gene summary (Entrez)i
Useful information about the gene from Entrez
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Metabolic proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of male genital organs Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Metabolic proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Human disease related genes Cancers Cancers of male genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000302[response to reactive oxygen species] GO:0002674[negative regulation of acute inflammatory response] GO:0004364[glutathione transferase activity] GO:0004602[glutathione peroxidase activity] GO:0005504[fatty acid binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006693[prostaglandin metabolic process] GO:0006749[glutathione metabolic process] GO:0006805[xenobiotic metabolic process] GO:0007417[central nervous system development] GO:0008432[JUN kinase binding] GO:0009890[negative regulation of biosynthetic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016740[transferase activity] GO:0019207[kinase regulator activity] GO:0031982[vesicle] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032872[regulation of stress-activated MAPK cascade] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032930[positive regulation of superoxide anion generation] GO:0034774[secretory granule lumen] GO:0035726[common myeloid progenitor cell proliferation] GO:0035730[S-nitrosoglutathione binding] GO:0035731[dinitrosyl-iron complex binding] GO:0035732[nitric oxide storage] GO:0043066[negative regulation of apoptotic process] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043407[negative regulation of MAP kinase activity] GO:0043409[negative regulation of MAPK cascade] GO:0043508[negative regulation of JUN kinase activity] GO:0043651[linoleic acid metabolic process] GO:0048147[negative regulation of fibroblast proliferation] GO:0051122[hepoxilin biosynthetic process] GO:0051771[negative regulation of nitric-oxide synthase biosynthetic process] GO:0070026[nitric oxide binding] GO:0070062[extracellular exosome] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070664[negative regulation of leukocyte proliferation] GO:0071222[cellular response to lipopolysaccharide] GO:0071638[negative regulation of monocyte chemotactic protein-1 production] GO:0097057[TRAF2-GSTP1 complex] GO:0098869[cellular oxidant detoxification] GO:1901687[glutathione derivative biosynthetic process] GO:1904813[ficolin-1-rich granule lumen] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
A0A087X243 [Direct mapping] Glutathione S-transferase P
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of male genital organs Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
