GENERAL INFORMATIONi
Gene namei GSK3B
Synonyms
Gene descriptioni Glycogen synthase kinase 3 beta
Protein classi Enzymes
Predicted locationi Membrane, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 3
Cytoband q13.33
Chromosome location (bp) 119821321 - 120094994
Number of transcriptsi 24
Ensembl ENSG00000082701 (version 109)
Entrez gene 2932
HGNC HGNC:4617
UniProt P49841 (UniProt - Evidence at protein level)
neXtProt NX_P49841
GeneCards GSK3B
Antibodypedia GSK3B antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 1, 2, 3, 4, 5, 6, 7. Requires primed phosphorylation of the majority of its substrates 8, 9. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis 10. May also mediate the development of insulin resistance by regulating activation of transcription factors 11. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase 12. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes 13. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA 14. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin 15. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules 16. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease 17. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex 18. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin 19. Is necessary for the establishment of neuronal polarity and axon outgrowth 20. Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity 21. Phosphorylates ZC3HAV1 which enhances its antiviral activity 22. Phosphorylates SNAI1, leading to its ubiquitination and proteasomal degradation 23, 24, 25, 26. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation 27. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 28, 29. Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation 30. Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation 31. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation 32. Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer 33. Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation 34. Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity 35, 36. Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR 37. Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). show less
Molecular function (UniProt)i Developmental protein, Kinase, Serine/threonine-protein kinase, Signal transduction inhibitor, Transferase
Biological process (UniProt)i Biological rhythms, Carbohydrate metabolism, Differentiation, Glycogen metabolism, Neurogenesis, Wnt signaling pathway
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
GSK3B-201
ENSP00000264235
ENST00000264235
P49841
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Q6FI27
[Target identity:100%; Query identity:100%] Glycogen synthase kinase-3 beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003170 [heart valve development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006983 [ER overload response]
GO:0007165 [signal transduction]
GO:0007212 [dopamine receptor signaling pathway]
GO:0007399 [nervous system development]
GO:0007623 [circadian rhythm]
GO:0008013 [beta-catenin binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0010508 [positive regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010822 [positive regulation of mitochondrion organization]
GO:0010975 [regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019082 [viral protein processing]
GO:0019901 [protein kinase binding]
GO:0021766 [hippocampus development]
GO:0030010 [establishment of cell polarity]
GO:0030011 [maintenance of cell polarity]
GO:0030154 [cell differentiation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030516 [regulation of axon extension]
GO:0030877 [beta-catenin destruction complex]
GO:0031175 [neuron projection development]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032886 [regulation of microtubule-based process]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034452 [dynactin binding]
GO:0035556 [intracellular signal transduction]
GO:0036016 [cellular response to interleukin-3]
GO:0042752 [regulation of circadian rhythm]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0045724 [positive regulation of cilium assembly]
GO:0045732 [positive regulation of protein catabolic process]
GO:0046777 [protein autophosphorylation]
GO:0046825 [regulation of protein export from nucleus]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048156 [tau protein binding]
GO:0048511 [rhythmic process]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0050321 [tau-protein kinase activity]
GO:0050770 [regulation of axonogenesis]
GO:0051059 [NF-kappaB binding]
GO:0051093 [negative regulation of developmental process]
GO:0051128 [regulation of cellular component organization]
GO:0060079 [excitatory postsynaptic potential]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0070885 [negative regulation of calcineurin-NFAT signaling cascade]
GO:0071109 [superior temporal gyrus development]
GO:0071300 [cellular response to retinoic acid]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0098793 [presynapse]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:0099171 [presynaptic modulation of chemical synaptic transmission]
GO:0106027 [neuron projection organization]
GO:0106310 [protein serine kinase activity]
GO:0150101 [regulation of microtubule anchoring at centrosome]
GO:1900034 [regulation of cellular response to heat]
GO:1900181 [negative regulation of protein localization to nucleus]
GO:1900271 [regulation of long-term synaptic potentiation]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1901984 [negative regulation of protein acetylation]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903566 [positive regulation of protein localization to cilium]
GO:1904339 [negative regulation of dopaminergic neuron differentiation]
GO:1904646 [cellular response to amyloid-beta]
GO:1904781 [positive regulation of protein localization to centrosome]
GO:1904886 [beta-catenin destruction complex disassembly]
GO:1905240 [negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:1990909 [Wnt signalosome]
GO:2000077 [negative regulation of type B pancreatic cell development]
GO:2000466 [negative regulation of glycogen (starch) synthase activity]
GO:2000740 [negative regulation of mesenchymal stem cell differentiation]
Show all
 420 aa
46.7 kDa 		No 0
GSK3B-202
ENSP00000324806
ENST00000316626
P49841
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003170 [heart valve development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006983 [ER overload response]
GO:0007165 [signal transduction]
GO:0007212 [dopamine receptor signaling pathway]
GO:0007399 [nervous system development]
GO:0007623 [circadian rhythm]
GO:0008013 [beta-catenin binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0010508 [positive regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010822 [positive regulation of mitochondrion organization]
GO:0010975 [regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019082 [viral protein processing]
GO:0019901 [protein kinase binding]
GO:0021766 [hippocampus development]
GO:0030010 [establishment of cell polarity]
GO:0030011 [maintenance of cell polarity]
GO:0030154 [cell differentiation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030516 [regulation of axon extension]
GO:0030877 [beta-catenin destruction complex]
GO:0031175 [neuron projection development]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032886 [regulation of microtubule-based process]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0034452 [dynactin binding]
GO:0035556 [intracellular signal transduction]
GO:0036016 [cellular response to interleukin-3]
GO:0042752 [regulation of circadian rhythm]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0045724 [positive regulation of cilium assembly]
GO:0045732 [positive regulation of protein catabolic process]
GO:0046777 [protein autophosphorylation]
GO:0046825 [regulation of protein export from nucleus]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048156 [tau protein binding]
GO:0048511 [rhythmic process]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0050321 [tau-protein kinase activity]
GO:0050770 [regulation of axonogenesis]
GO:0051059 [NF-kappaB binding]
GO:0051093 [negative regulation of developmental process]
GO:0051128 [regulation of cellular component organization]
GO:0060079 [excitatory postsynaptic potential]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0070885 [negative regulation of calcineurin-NFAT signaling cascade]
GO:0071109 [superior temporal gyrus development]
GO:0071300 [cellular response to retinoic acid]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0098793 [presynapse]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:0099171 [presynaptic modulation of chemical synaptic transmission]
GO:0106027 [neuron projection organization]
GO:0106310 [protein serine kinase activity]
GO:0150101 [regulation of microtubule anchoring at centrosome]
GO:1900034 [regulation of cellular response to heat]
GO:1900181 [negative regulation of protein localization to nucleus]
GO:1900271 [regulation of long-term synaptic potentiation]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:1901215 [negative regulation of neuron death]
GO:1901216 [positive regulation of neuron death]
GO:1901984 [negative regulation of protein acetylation]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903566 [positive regulation of protein localization to cilium]
GO:1904339 [negative regulation of dopaminergic neuron differentiation]
GO:1904646 [cellular response to amyloid-beta]
GO:1904781 [positive regulation of protein localization to centrosome]
GO:1904886 [beta-catenin destruction complex disassembly]
GO:1905240 [negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation]
GO:1990909 [Wnt signalosome]
GO:2000077 [negative regulation of type B pancreatic cell development]
GO:2000466 [negative regulation of glycogen (starch) synthase activity]
GO:2000740 [negative regulation of mesenchymal stem cell differentiation]
Show all
 433 aa
48 kDa 		No 0
GSK3B-205
ENSP00000497956
ENST00000650344
A0A3B3ITW1
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0006468 [protein phosphorylation]
GO:0009968 [negative regulation of signal transduction]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016740 [transferase activity]
GO:0048511 [rhythmic process]
GO:0050321 [tau-protein kinase activity]
GO:0051093 [negative regulation of developmental process]
GO:0051128 [regulation of cellular component organization]
Show all
 387 aa
43.5 kDa 		No 0
GSK3B-216
ENSP00000504338
ENST00000676910
A0A7I2V589
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 141 aa
16.7 kDa 		No 0
GSK3B-218
ENSP00000504055
ENST00000677034
A0A7I2V4F3
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 110 aa
11.7 kDa 		No 0
GSK3B-219
ENSP00000504697
ENST00000677046
A0A7I2V675
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 46 aa
4.7 kDa 		No 0
GSK3B-224
ENSP00000503497
ENST00000677338
A0A7I2V3N7
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3.1 kDa 		No 0
GSK3B-225
ENSP00000503882
ENST00000677362
A0A7I2YQK2
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
Show all
 69 aa
7.2 kDa 		No 0
GSK3B-226
ENSP00000504538
ENST00000677400
A0A7I2YQU1
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 59 aa
6.8 kDa 		No 0
GSK3B-227
ENSP00000503687
ENST00000677423
A0A7I2V3N7
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3.1 kDa 		No 0
GSK3B-236
ENSP00000504503
ENST00000677875
A0A7I2V5M2
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
Show all
 65 aa
7.9 kDa 		No 0
GSK3B-237
ENSP00000503134
ENST00000677878
A0A7I2V2V4
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 102 aa
11.3 kDa 		No 0
GSK3B-238
ENSP00000504148
ENST00000677885
A0A7I2V4X2
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 71 aa
8.5 kDa 		No 0
GSK3B-239
ENSP00000503112
ENST00000677903
A0A7I2V3N7
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3.1 kDa 		No 0
GSK3B-242
ENSP00000503088
ENST00000678013
A0A7I2V2T2
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 142 aa
16.3 kDa 		No 0
GSK3B-245
ENSP00000504704
ENST00000678159
A0A7I2V5P4
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 39 aa
3.9 kDa 		No 0
GSK3B-246
ENSP00000504266
ENST00000678181
A0A7I2V5G5
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
Show all
 90 aa
10.5 kDa 		No 0
GSK3B-253
ENSP00000503868
ENST00000678439
A0A7I2YQK0
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0006468 [protein phosphorylation]
GO:0009968 [negative regulation of signal transduction]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016740 [transferase activity]
GO:0048511 [rhythmic process]
GO:0050321 [tau-protein kinase activity]
GO:0051093 [negative regulation of developmental process]
GO:0051128 [regulation of cellular component organization]
Show all
 470 aa
52.5 kDa 		No 1
GSK3B-255
ENSP00000503494
ENST00000678561
A0A7I2V3J4
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006468 [protein phosphorylation]
GO:0009968 [negative regulation of signal transduction]
GO:0016020 [membrane]
GO:0016740 [transferase activity]
GO:0050321 [tau-protein kinase activity]
GO:0051093 [negative regulation of developmental process]
GO:0051128 [regulation of cellular component organization]
Show all
 224 aa
25.6 kDa 		No 0
GSK3B-259
ENSP00000503398
ENST00000678787
A0A7I2V3D8
[Direct mapping] Glycogen synthase kinase-3 beta
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 97 aa
10.7 kDa 		No 0
GSK3B-261
ENSP00000503626
ENST00000679066
A0A7I2YQG6
[Direct mapping] Glycogen synthase kinase-3 beta
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
7.4 kDa 		No 0
GSK3B-266
ENSP00000504252
ENST00000679188
A0A7I2V4W7
[Direct mapping] Glycogen synthase kinase-3 beta
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Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 69 aa
8.3 kDa 		No 0
GSK3B-268
ENSP00000502998
ENST00000679201
A0A7I2YQ81
[Direct mapping] Glycogen synthase kinase-3 beta
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 108 aa
12.8 kDa 		No 0
GSK3B-269
ENSP00000502943
ENST00000679206
A0A7I2V2I5
[Direct mapping] Glycogen synthase kinase-3 beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 45 aa
5.3 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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