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The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.
The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".
Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.
Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.
& Survival analysisi
Kaplan-Meier plots summarize results from analysis of correlation between mRNA expression level and patient survival. Patients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent.
SLC25A3 is not prognostic in Skin Cuteneous Melanoma (TCGA)
Stage:
Survival analysis
Current cut offi
Current cut-off shows the cut-off (FPKM) currently selected. It may be changed manually. When the current cut-off is changed, the vertical dashed line indicating cut-off, the interactive survival scatter plot and the Kaplan-Meier curve will be automatically adjusted to show results accordingly.
:
Best expression cut offi
Based on the FPKM value of each gene, patients were classified into two groups and association between prognosis (survival) and gene expression (FPKM) was examined. The best expression cut-off refers the FPKM value that yields maximal difference with regard to survival between the two groups at the lowest log-rank P-value. Best expression cut-off was selected based on survival analysis .
When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the best expression cut-off.
Median expression refers to the median FPKM value calculated based on the gene expression (FPKM) data from all patients in this dataset. When clicking on this number, the vertical dashed line indicating cut-off, the interactive survival plot, and the Kaplan-Meier curve will be adjusted to show results based on the median expression.
Median follow up time refers to the median time (years) after diagnosis with this type of cancer, based on clinical data from all patients in this dataset.
: N/A
P scorei
Log-rank P value for Kaplan-Meier plot showing results from analysis of correlation between mRNA expression level and patient survival.
N/A
3-year survival highi
5-year survival for patients with higher expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
3-year survival lowi
5-year survival for patients with lower expression than the expression cutoff.
For melanoma and glioma, 3-year survival is shown.
N/A
TCGA RNA samplesi
RNA-seq data is reported as average FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA) .
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. FPKM values of the individual samples are presented next to the box plot.
Average TPM
386.3
Number of samples
99
Samples
Sample
Description
TPM
TCGA-ER-A19T-01A
51 years, male, white, stage:Stage IV, dead, 270 days
1106.1
TCGA-EB-A44O-01A
69 years, male, white, stage:Stage IIB, alive, 81 days
742.5
TCGA-BF-AAP2-01A
62 years, male, white, stage:Stage IIB, alive, 405 days
714.6
TCGA-EB-A5SE-01A
73 years, male, white, stage:Stage IIB, dead, 401 days
681.7
TCGA-BF-A1PV-01A
74 years, female, white, stage:Stage IIC, alive, 14 days
668.2
TCGA-BF-AAP6-01A
55 years, male, white, stage:Stage III, alive, 325 days
652.3
TCGA-BF-AAP1-01A
86 years, male, white, stage:Stage IIC, alive, 409 days
608.3
TCGA-EB-A3XC-01A
74 years, male, white, stage:Stage IIC, alive, 650 days
592.5
TCGA-BF-A1PZ-01A
71 years, female, white, stage:Stage IIB, alive, 853 days
591.7
TCGA-BF-A3DL-01A
84 years, female, white, stage:Stage IIIB, alive, 769 days
590.7
TCGA-EB-A431-01A
34 years, male, white, stage:Stage IIC, alive, 568 days
585.5
TCGA-BF-A5ES-01A
76 years, female, white, stage:Stage IIC, alive, 490 days
567.9
TCGA-D9-A4Z3-01A
73 years, female, white, stage:Stage IIIC, alive, 505 days
563.9
TCGA-BF-AAP4-01A
61 years, male, white, stage:Stage IIC, alive, 335 days
559.0
TCGA-BF-AAOX-01A
83 years, male, white, stage:Stage IIC, alive, 444 days
555.4
TCGA-FR-A2OS-01A
49 years, female, white, stage:Stage IIC, dead, 368 days
553.6
TCGA-GF-A2C7-01A
48 years, male, white, stage:Stage IIC, alive, 21 days
513.6
TCGA-EB-A5SF-01A
78 years, female, white, stage:Stage IIC, dead, 369 days
509.3
TCGA-WE-A8K4-01A
85 years, male, white, stage:Stage IIB, alive, 614 days
505.2
TCGA-D9-A4Z5-01A
68 years, male, white, stage:Stage IIB, alive, 218 days
499.5
TCGA-BF-A3DM-01A
63 years, male, white, stage:Stage IIA, alive, 601 days
495.3
TCGA-XV-AAZV-01A
56 years, female, white, stage:Stage II, alive, 412 days
493.7
TCGA-EB-A6QZ-01A
76 years, female, white, stage:Stage IIA, dead, 352 days
489.4
TCGA-FS-A1ZN-01A
43 years, male, white, stage:Stage IIIA, dead, 730 days
483.0
TCGA-BF-A1Q0-01A
80 years, male, white, stage:Stage IIC, alive, 831 days
481.5
TCGA-EB-A44P-01A
58 years, female, white, stage:Stage IIC, alive, 741 days
475.9
TCGA-BF-A5EP-01A
75 years, female, white, stage:Stage IIIC, alive, 335 days
473.8
TCGA-ER-A19K-01A
79 years, female, white, stage:Stage IIC, dead, 469 days
469.2
TCGA-EB-A51B-01A
53 years, male, white, stage:Stage IIC, alive, 931 days
456.0
TCGA-EB-A3XB-01A
63 years, male, white, stage:Stage II, alive, 796 days
450.9
TCGA-EB-A42Y-01A
73 years, female, asian, stage:Stage IIC, dead, 721 days
450.5
TCGA-EB-A85J-01A
66 years, female, white, stage:Stage IIB, alive, 360 days
448.1
TCGA-ER-A2NF-01A
53 years, male, white, stage:Stage IIIB, dead, 877 days
438.7
TCGA-EB-A3XF-01A
57 years, male, white, stage:Stage IIC, alive, 278 days
428.3
TCGA-EB-A82C-01A
70 years, female, asian, stage:Stage IIC, alive, 17 days
424.8
TCGA-ER-A42H-01A
76 years, male, white, stage:'--, dead, 426 days
417.3
TCGA-EB-A82B-01A
58 years, female, asian, stage:Stage III, alive, 390 days
412.5
TCGA-EB-A6QY-01A
71 years, male, white, stage:Stage IIC, alive, 382 days
412.1
TCGA-EB-A97M-01A
66 years, male, white, stage:Stage IIC, alive, 414 days
407.2
TCGA-EB-A57M-01A
56 years, male, asian, stage:Stage IIIB, dead, 472 days
407.2
TCGA-BF-A5EO-01A
65 years, male, white, stage:Stage IIC, alive, 703 days
404.6
TCGA-EB-A6R0-01A
58 years, female, white, stage:Stage IIC, dead, 608 days
399.9
TCGA-ER-A196-01A
64 years, female, white, stage:Stage IIC, alive, 1785 days
397.7
TCGA-GF-A769-01A
39 years, male, white, stage:Stage IIC, dead, 1070 days
394.1
TCGA-EB-A44N-01A
59 years, male, white, stage:Stage IIC, dead, 205 days
393.0
TCGA-XV-A9W5-01A
51 years, male, white, stage:Not Reported, alive, 392 days
388.8
TCGA-EB-A41B-01A
76 years, female, white, stage:Stage IIC, alive, 291 days
378.4
TCGA-FR-A3R1-01A
69 years, male, white, stage:Stage IIC, alive, 685 days
378.3
TCGA-EB-A24D-01A
72 years, male, white, stage:Stage IIIB, alive, 645 days
372.2
TCGA-EB-A4IQ-01A
42 years, female, asian, stage:Stage IIIB, dead, 636 days
368.4
TCGA-BF-A9VF-01A
77 years, male, white, stage:Stage IIC, alive, 440 days
363.3
TCGA-BF-A3DN-01A
81 years, female, white, stage:Stage IIIC, alive, 717 days
363.0
TCGA-EB-A3HV-01A
37 years, male, white, stage:Stage IIC, alive, 39 days
362.2
TCGA-EB-A5FP-01A
65 years, female, white, stage:Stage IV, dead, 454 days
361.4
TCGA-YG-AA3N-01A
67 years, male, stage:Stage IIC, alive, 306 days
359.9
TCGA-GN-A263-01A
24 years, male, white, stage:Stage IV, dead, 467 days
357.2
TCGA-EB-A42Z-01A
49 years, male, asian, stage:Stage IIIC, alive, 441 days
355.1
TCGA-EB-A3XD-01A
53 years, female, white, stage:Stage IIC, alive, 1160 days
354.0
TCGA-EB-A4XL-01A
56 years, female, white, stage:Stage IIC, alive, 777 days
350.9
TCGA-IH-A3EA-01A
61 years, male, white, stage:Stage IIC, alive, 524 days
348.2
TCGA-BF-A1PX-01A
56 years, male, white, stage:Stage IIIB, dead, 282 days
344.2
TCGA-BF-AAP7-01A
76 years, female, white, stage:Stage IIC, alive, 318 days
339.5
TCGA-BF-A5ER-01A
63 years, male, white, stage:Stage IIC, alive, 327 days
331.3
TCGA-EB-A4IS-01A
77 years, male, white, stage:Stage IIB, alive, 774 days
327.6
TCGA-BF-AAOU-01A
73 years, female, white, stage:Stage IIC, alive, 476 days
327.1
TCGA-GN-A4U5-01A
61 years, female, white, stage:Stage IB, alive, 1156 days
321.0
TCGA-EB-A550-01A
75 years, female, white, stage:Stage IIC, dead, 264 days
319.1
TCGA-XV-AAZY-01A
76 years, female, white, stage:Stage IIIC, alive, 405 days
310.9
TCGA-BF-A5EQ-01A
63 years, male, white, stage:Stage IIC, alive, 323 days
293.5
TCGA-EB-A5VU-01A
56 years, male, asian, stage:Stage IIIB, dead, 321 days
292.7
TCGA-FR-A728-01A
54 years, female, white, stage:Stage IIIB, alive, 583 days
289.5
TCGA-EB-A3Y6-01A
56 years, female, white, stage:Stage IIC, alive, 126 days
284.7
TCGA-BF-A3DJ-01A
36 years, female, white, stage:Stage IIIB, alive, 464 days
283.5
TCGA-EB-A24C-01A
56 years, male, white, stage:'--, alive, 632 days
282.6
TCGA-EB-A85I-01A
66 years, male, white, stage:Stage IIC, alive, 362 days
276.1
TCGA-D9-A4Z2-01A
50 years, male, white, stage:Stage IIIC, dead, 190 days
270.8
TCGA-EB-A1NK-01A
48 years, male, white, stage:Stage IIC, alive, 1039 days
268.1
TCGA-BF-A1PU-01A
46 years, female, white, stage:Stage IIC, alive, 387 days
266.9
TCGA-FW-A5DX-01A
71 years, male, white, stage:Stage IIIC, alive, 640 days
263.9
TCGA-EB-A5UM-01A
48 years, female, white, stage:Stage IIC, alive, 779 days
252.0
TCGA-EB-A3Y7-01A
86 years, female, white, stage:Stage IIIB, dead, 326 days
250.6
TCGA-EB-A299-01A
63 years, male, white, stage:Stage IIA, alive, 378 days
249.1
TCGA-EB-A551-01A
78 years, female, white, stage:Stage IIIC, alive, 590 days
248.5
TCGA-GN-A8LN-01A
68 years, male, white, stage:Stage IIC, alive, 772 days
243.8
TCGA-XV-AAZW-01A
62 years, female, white, stage:Stage II, dead, 393 days
221.7
TCGA-D9-A3Z4-01A
54 years, male, white, stage:Stage IIIC, dead, 519 days
213.1
TCGA-XV-A9W2-01A
81 years, male, white, stage:Stage I, alive, 417 days
196.4
TCGA-GN-A26C-01A
77 years, male, white, stage:Stage IIIC, dead, 821 days
180.4
TCGA-EB-A4P0-01A
82 years, male, white, stage:Stage IIC, dead, 326 days
174.7
TCGA-ER-A194-01A
77 years, male, white, stage:'--, dead, 1354 days
174.5
TCGA-EB-A4OY-01A
65 years, female, white, stage:Stage IIIB, alive, 977 days
170.3
TCGA-BF-AAP8-01A
58 years, male, white, stage:Stage IIC, alive, 447 days
169.0
TCGA-EB-A3XE-01A
77 years, female, white, stage:Stage IIA, alive, 180 days
164.5
TCGA-ER-A2NB-01A
57 years, male, white, stage:Stage IIIB, dead, 857 days
157.1
TCGA-EB-A4OZ-01A
41 years, female, white, stage:Stage IIIC, alive, 620 days
81.0
TCGA-D3-A5GT-01A
43 years, male, white, stage:Stage IIIC, alive, 487 days
78.8
TCGA-EB-A553-01A
62 years, male, white, stage:Stage IIC, alive, 226 days
59.7
TCGA-DA-A960-01A
73 years, male, white, stage:Stage IIB, alive, 804 days
57.8
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MELANOMA - Protein expressioni
A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here.
Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
The Human Protein Atlas project is funded
