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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Succinate dehydrogenase complex flavoprotein subunit A
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Citric acid cycle related proteins Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
p15.33
Chromosome location (bp)
218303 - 257082
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable) 1. SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor 2....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Electron transport, Transport, Tricarboxylic acid cycle
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
FAD, Flavoprotein
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Transporters Primary Active Transporters SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of endocrine organs Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Mitochondrial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000104[succinate dehydrogenase activity] GO:0005515[protein binding] GO:0005730[nucleolus] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005749[mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)] GO:0006099[tricarboxylic acid cycle] GO:0006105[succinate metabolic process] GO:0006121[mitochondrial electron transport, succinate to ubiquinone] GO:0007399[nervous system development] GO:0008177[succinate dehydrogenase (ubiquinone) activity] GO:0009055[electron transfer activity] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0016627[oxidoreductase activity, acting on the CH-CH group of donors] GO:0022900[electron transport chain] GO:0022904[respiratory electron transport chain] GO:0042776[proton motive force-driven mitochondrial ATP synthesis] GO:0045257[succinate dehydrogenase complex (ubiquinone)] GO:0050660[flavin adenine dinucleotide binding] GO:0102040[fumarate reductase (menaquinone)]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Transporters Primary Active Transporters SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of endocrine organs Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Mitochondrial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000104[succinate dehydrogenase activity] GO:0005515[protein binding] GO:0005730[nucleolus] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005749[mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)] GO:0006099[tricarboxylic acid cycle] GO:0006105[succinate metabolic process] GO:0006121[mitochondrial electron transport, succinate to ubiquinone] GO:0007399[nervous system development] GO:0008177[succinate dehydrogenase (ubiquinone) activity] GO:0009055[electron transfer activity] GO:0016020[membrane] GO:0016491[oxidoreductase activity] GO:0016627[oxidoreductase activity, acting on the CH-CH group of donors] GO:0022900[electron transport chain] GO:0022904[respiratory electron transport chain] GO:0042776[proton motive force-driven mitochondrial ATP synthesis] GO:0050660[flavin adenine dinucleotide binding] GO:0102040[fumarate reductase (menaquinone)]
The Human Protein Atlas project is funded
