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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q25.3
Chromosome location (bp)
84980440 - 85139145
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes 1. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development 2. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling 3. Protects against cell death induced by hydrogen peroxide and staurosporine 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
cAMP, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O60658 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
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Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001934[positive regulation of protein phosphorylation] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0005829[cytosol] GO:0006198[cAMP catabolic process] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016787[hydrolase activity] GO:0019900[kinase binding] GO:0046872[metal ion binding] GO:0047555[3',5'-cyclic-GMP phosphodiesterase activity] GO:0060548[negative regulation of cell death] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071364[cellular response to epidermal growth factor stimulus] GO:1903206[negative regulation of hydrogen peroxide-induced cell death]
O60658 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Show all
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934[positive regulation of protein phosphorylation] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0005829[cytosol] GO:0006198[cAMP catabolic process] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016787[hydrolase activity] GO:0019900[kinase binding] GO:0046872[metal ion binding] GO:0047555[3',5'-cyclic-GMP phosphodiesterase activity] GO:0060548[negative regulation of cell death] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071364[cellular response to epidermal growth factor stimulus] GO:1903206[negative regulation of hydrogen peroxide-induced cell death]
O60658 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Show all
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934[positive regulation of protein phosphorylation] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0005829[cytosol] GO:0006198[cAMP catabolic process] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016787[hydrolase activity] GO:0019900[kinase binding] GO:0046872[metal ion binding] GO:0047555[3',5'-cyclic-GMP phosphodiesterase activity] GO:0060548[negative regulation of cell death] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071364[cellular response to epidermal growth factor stimulus] GO:1903206[negative regulation of hydrogen peroxide-induced cell death]
O60658 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Show all
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934[positive regulation of protein phosphorylation] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0005829[cytosol] GO:0006198[cAMP catabolic process] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016787[hydrolase activity] GO:0019900[kinase binding] GO:0046872[metal ion binding] GO:0047555[3',5'-cyclic-GMP phosphodiesterase activity] GO:0060548[negative regulation of cell death] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0071364[cellular response to epidermal growth factor stimulus] GO:1903206[negative regulation of hydrogen peroxide-induced cell death]
The Human Protein Atlas project is funded
