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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Mitogen-activated protein kinase kinase kinase kinase 4
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q11.2
Chromosome location (bp)
101696850 - 101894690
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway 1. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway 2. Phosphorylates SMAD1 on Thr-322 3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
G5E948 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4
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MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
O95819 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001953[negative regulation of cell-matrix adhesion] GO:0004111[creatine kinase activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0008017[microtubule binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0030335[positive regulation of cell migration] GO:0032014[positive regulation of ARF protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0043408[regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0046328[regulation of JNK cascade] GO:0048812[neuron projection morphogenesis] GO:0051549[positive regulation of keratinocyte migration] GO:0051894[positive regulation of focal adhesion assembly] GO:0106310[protein serine kinase activity] GO:0120183[positive regulation of focal adhesion disassembly]
O95819 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001953[negative regulation of cell-matrix adhesion] GO:0004111[creatine kinase activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0008017[microtubule binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0030335[positive regulation of cell migration] GO:0032014[positive regulation of ARF protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0043408[regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0046328[regulation of JNK cascade] GO:0048812[neuron projection morphogenesis] GO:0051549[positive regulation of keratinocyte migration] GO:0051894[positive regulation of focal adhesion assembly] GO:0106310[protein serine kinase activity] GO:0120183[positive regulation of focal adhesion disassembly]
E7ENQ1 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4
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MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
H7C360 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
H7C0P6 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
E7EN19 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4
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MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
E7EX83 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
O95819 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4
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A0A0D9SEY1 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4, isoform CRA_a V9HWH3 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 31
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001953[negative regulation of cell-matrix adhesion] GO:0004111[creatine kinase activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0008017[microtubule binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0030335[positive regulation of cell migration] GO:0032014[positive regulation of ARF protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0043408[regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0046328[regulation of JNK cascade] GO:0048812[neuron projection morphogenesis] GO:0051549[positive regulation of keratinocyte migration] GO:0051894[positive regulation of focal adhesion assembly] GO:0106310[protein serine kinase activity] GO:0120183[positive regulation of focal adhesion disassembly]
O95819 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 4
Show all
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001953[negative regulation of cell-matrix adhesion] GO:0004111[creatine kinase activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005737[cytoplasm] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0008017[microtubule binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0030335[positive regulation of cell migration] GO:0032014[positive regulation of ARF protein signal transduction] GO:0035556[intracellular signal transduction] GO:0043066[negative regulation of apoptotic process] GO:0043408[regulation of MAPK cascade] GO:0043547[positive regulation of GTPase activity] GO:0046328[regulation of JNK cascade] GO:0048812[neuron projection morphogenesis] GO:0051549[positive regulation of keratinocyte migration] GO:0051894[positive regulation of focal adhesion assembly] GO:0106310[protein serine kinase activity] GO:0120183[positive regulation of focal adhesion disassembly]
The Human Protein Atlas project is funded
